Protein Alignment Nup153 and NUP2

DIOPT Version :10

• Sequence 1: NP_001097002.1
• Gene: Nup153 / 32630
• FlyBaseID: FBgn0061200
• Length: 1929
• Species: Drosophila melanogaster
• Sequence 2: NP_013439.1
• Gene: NUP2 / 851048
• SGDID: S000004327
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 707
• Identity: 158/707 - (22%)
• Similarity: 238/707 - (33%)
• Gaps: 223/707 - (31%)

  Fly  1264 MPE---AFNPAATTANSAASSVPKFRF-----GFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQS 1320
            ||:   ||.|..:..:........|.|     |....:....|:.|:.:.....:.||.......
Yeast    43 MPKRRMAFKPFGSAKSDETKQASSFSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDDL 107

  Fly  1321 NQGKDVADSKK------------TEAPKTFMFGVSKVEEPKTVSFGTGIKETTATSSTEATAPTP 1373
            ..||.:||.:.            .|||      |..:|.|            |.|...:
Yeast   108 VLGKPLADLRPLFTRYELYIKNILEAP------VKSIENP------------TQTKGND------ 148

  Fly  1374 AAAAPAPVQFVFKAPTTATTASSLTTTISTTSNA-PALGG--FSFGAPSSSSTVSSSTTSTSANP 1435
              |.||.|:.|.|:..:::...........|.:| |.:..  ||||....:   .....|.|.|.
Yeast   149 --AKPAKVEDVQKSSDSSSEDEVKVEGPKFTIDAKPPISDSVFSFGPKKEN---RKKDESDSEND 208

  Fly  1436 AAVK-PMFSWSGAGSA----VSSTSSSQQPVAKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGLD 1495
            ..:| |.|.:||..|:    ::.::...:...:.....|..||:|.||..|.:|    .|.| |.
Yeast   209 IEIKGPEFKFSGTVSSDVFKLNPSTDKNEKKTETNAKPFSFSSATSTTEQTKSK----NPLS-LT 268

  Fly  1496 PAAATSA---PAAGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPATPTNPSVSSIFGAPATSTTA 1557
            .|..|:.   ..|.|.|:||::....:..|..:|.|||    |.|.|:....|..||    |||.
Yeast   269 EATKTNVDNNSKAEASFTFGTKHAADSQNNKPSFVFGQ----AAAKPSLEKSSFTFG----STTI 325

  Fly  1558 STSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGSGTTTTPSFGWSSNGDAA 1622
            .   ......||:|         |.|       ||.:|          ...:.|||.:|
Yeast   326 E---KKNDENSTSN---------SKP-------EKSSD----------SNDSNPSFSFS------ 355

  Fly  1623 KSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAATTPAGGN 1687
                       :||.:....:.|.|.    ||..:||.|.||....|  ||:|
Yeast   356 -----------IPSKNTPDASKPSFS----FGVPNSSKNETSKPVFS--FGAA------------ 391

  Fly  1688 AALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPA 1752
                                   ||:|..|:...:  .|.....::.|.|   :.|.:||.....
Yeast   392 -----------------------TPSAKEASQEDD--NNNVEKPSSKPAF---NLISNAGTEKEK 428

  Fly  1753 AAAPLAAPALPGAFNFGGATAATPAASSAP----FVFGSSTNEPLAKPSFNF---TGSAASSTAP 1810
            .:...:.|    ||:||.:..:....|..|    .|.|.:..:...||:|:|   |.:..::...
Yeast   429 ESKKDSKP----AFSFGISNGSESKDSDKPSLPSAVDGENDKKEATKPAFSFGINTNTTKTADTK 489

  Fly  1811 APAFNFTANTAATNNPSGGDSHPRIFQFGSSQPAANNQFGGAGGATNNSAGGMPMFNFSPGAPQM 1875
            ||.|.|.::..|.|.    :...:.|.||:|||             ||:    |.|:|.
Yeast   490 APTFTFGSSALADNK----EDVKKPFSFGTSQP-------------NNT----PSFSFG------ 527

  Fly  1876 QSTPNANALFQFSATSTAPANIFAFNPP--------------------AAGNSAQSS 1912
            ::|.|..|....|...:.|:..|.|:.|                    |.||.:|.:
Yeast   528 KTTANLPANSSTSPAPSIPSTGFKFSLPFEQKGSQTTTNDSKEESTTEATGNESQDA 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	RanBP2-type Zn finger	864..883	CDD:275375
		zf-RanBP	903..931	CDD:395516
		RanBP2-type Zn finger	907..926	CDD:275375
		zf-RanBP	968..992	CDD:395516
		RanBP2-type Zn finger	968..987	CDD:275375
		zf-RanBP	1009..1038	CDD:395516
		RanBP2-type Zn finger	1013..1032	CDD:275375
		zf-RanBP	1072..1097	CDD:395516
		RanBP2-type Zn finger	1072..1091	CDD:275375
		zf-RanBP	1126..1155	CDD:395516
		RanBP2-type Zn finger	1130..1149	CDD:275375
		ZnF_RBZ	1239..1261	CDD:197784
		RanBP2-type Zn finger	1241..1260	CDD:275375
NUP2	NP_013439.1	NUP50	2..71	CDD:462629	7/27 (26%)
		PRK08581	233..>486	CDD:236304	83/361 (23%)
		RanBD	588..715	CDD:197549