DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup153 and NUP214

DIOPT Version :9

Sequence 1:NP_001097002.1 Gene:Nup153 / 32630 FlyBaseID:FBgn0061200 Length:1929 Species:Drosophila melanogaster
Sequence 2:NP_005076.3 Gene:NUP214 / 8021 HGNCID:8064 Length:2090 Species:Homo sapiens


Alignment Length:1861 Identity:421/1861 - (22%)
Similarity:649/1861 - (34%) Gaps:609/1861 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 PLLSSTPAAPLAAATSSSSSQMYKGVSHIAPHRRNHLNLYGSQRQREPAYNFFTGNEAAEGSTGD 303
            |:.||..|.|::..:|:|.......:||..|     |:...|....:.:........:|:||:..
Human   599 PVSSSQSAPPMSPFSSASKPAASGPLSHPTP-----LSAPPSSVPLKSSVLPSPSGRSAQGSSSP 658

  Fly   304 LPHSIRRSLNI------PFGGSSTATSYNNSLSSLPNHK----RPSL--IGKQTHRRDLTMDE-- 354
            :|..:::|..|      |  ||..|.|...:::....|:    .|.:  ||::.......::|  
Human   659 VPSMVQKSPRITPPAAKP--GSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELK 721

  Fly   355 ---------TGTGPAM-----SSEEHLNHLLRISRTNNN--------------------TSNNNN 385
                     .||...|     .|::....||.|..|..:                    .:...|
Human   722 ARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQN 786

  Fly   386 NNNNNNNVIETKTRRSELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSH---------YNSNS 441
            ..|.::..:....:|..         |.:||:.:.|          :|..|         .|...
Human   787 ERNRDSGYLHLLYKRPL---------DPKSEAQLQE----------IRRLHQYVKFAVQDVNDVL 832

  Fly   442 NLEFYGNLQSSK-----------SIFNRSNTAAQQSHRNSTWSLNSLTQRRRFNASIYGSTSALS 495
            :||:..:|:..|           ::|   ||.|     |:...:|.  ||:|.| .:..|...| 
Human   833 DLEWDQHLEQKKKQRHLLVPERETLF---NTLA-----NNREIINQ--QRKRLN-HLVDSLQQL- 885

  Fly   496 DSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNL--SSSAASSMLGLNSAGSSPA 558
                                                ||:.:::|  .|||..|...::|.     
Human   886 ------------------------------------RLYKQTSLWSLSSAVPSQSSIHSF----- 909

  Fly   559 HQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESY--STPL 621
                                 .||..||.             ..|..||      :||:  |.|.
Human   910 ---------------------DSDLESLC-------------NALLKTT------IESHTKSLPK 934

  Fly   622 IDAKRMGSSIKEHQ-----SSRQQRQGTPATPYLRST---SASRNVSV-PNHINELAELRSNKLL 677
            :.||.  |.:|:.|     :.|:       ||.:|||   |.||:..: ..:..:|.|:.|..  
Human   935 VPAKL--SPMKQAQLRNFLAKRK-------TPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTS-- 988

  Fly   678 VPTMQQLLERRRLHRVTQNSRDVV----HSQNVRAGGENNQEKPKPT-APYVAPIDQSANHTQHT 737
              ::.|.||........::...||    |:..||.      ...:|: .|:.||..:|  |..|.
Human   989 --SVSQSLESEDARTSCKDDEAVVQAPRHAPVVRT------PSIQPSLLPHAAPFAKS--HLVHG 1043

  Fly   738 NK----------MRSRLSHQTRNK---ETRTAEEEAPP---PLDLPQISFP-----DMAS-APKF 780
            :.          ..|::..|..:.   .|:|.:..||.   |:..||.:..     .||| ||..
Human  1044 SSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAV 1108

  Fly   781 DLIIKPT---VPVV----------SKPST----TDPIQSSKSSNTNLS--TTNSKQMPNFLANPQ 826
            :.:.:.|   ||.|          :.|||    :.|..::|:.:..|:  ..|..:..:.:.:.:
Human  1109 NTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLK 1173

  Fly   827 PAAPIVNFAANGNVSAISKPS-------------------KRTFTFS-----------EPTPLSN 861
            |:.|.   .|:|.:|:..|.|                   .:.|:||           .|||.||
Human  1174 PSGPT---PASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSN 1235

  Fly   862 F--QENCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTINGTPSSKEWECDTCMVRNKPEINKCV 924
            |  .:...|..|.:     |.|    |...:...|:|:....|.|......|......|      
Human  1236 FTAAQGATPSTKES-----SQP----DAFSSGGGSKPSYEAIPESSPPSGITSASNTTP------ 1285

  Fly   925 ACETAKPVASAAPVQAPLPPSTAAIDTQSFVGFGDRFKKSTTAWECDACMLSNKAEA--SKCIAC 987
                .:|.||::   .|:.||..|:              |||         |:|.|.  ||....
Human  1286 ----GEPAASSS---RPVAPSGTAL--------------STT---------SSKLETPPSKLGEL 1320

  Fly   988 ETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVA 1052
            ..|.......:.:||.|....                      |.:|.||               
Human  1321 LFPSSLAGETLGSFSGLRVGQ----------------------ADDSTKP--------------- 1348

  Fly  1053 TPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPSINNNLPAGS 1117
                                       :|||             |||.: .|:.|:..:.:|:| 
Human  1349 ---------------------------TNKA-------------SSTSL-TSTQPTKTSGVPSG- 1371

  Fly  1118 GFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNS---QARNSNSESALISSISSSSASFSGS 1179
               .:||...         |:.|.::....:..|..|   .|..|.|.:|:..|:..:||..||.
Human  1372 ---FNFTAPP---------VLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGV 1424

  Fly  1180 LSRPSSRSSSGSTS-TCGSVCSGSIVSISSTTESAKALSAKKVPPK-PDAGFQQLVAAQKTSTWE 1242
            :|...:..|:|.|| :.||..:.|.|..|:...:.   :|..:|.. |...|..|:::..|.:..
Human  1425 ISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTT---AATPLPTSFPTLSFGSLLSSATTPSLP 1486

  Fly  1243 CEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSV-------------PKFRFGFSHVKE 1294
            ..|       .|.|.......:||  .|..:..:::|:|:             |:..........
Human  1487 MSA-------GRSTEEATSSALPE--KPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPV 1542

  Fly  1295 VVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKTFMF---GVSKVEEPKTVSFGTG 1356
            :.:|:|..:.|.|.:::..:.....:.....|.|::....|....|   |.:.|......|.|..
Human  1543 LAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPV 1607

  Fly  1357 IKETTAT----SSTEATAPTPAAAAPA-----PVQFVFKAPTTATTASSLTTTISTTSNAP-ALG 1411
            ..||::|    |:|...||.|:|.|.|     ....||..|..|:::|:.....:.|:.|| |..
Human  1608 AVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATP 1672

  Fly  1412 GFSFGAPSSSSTVSSSTTSTSANPAAVKPMFSWSG----------------------------AG 1448
            .|...|.|::.::....|.::|:.||..|..|.||                            |.
Human  1673 VFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSAS 1737

  Fly  1449 SAVSSTSSSQQPVAKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGS 1513
            ||.|..|.||...:..|..|...||   |.|:||..||           .|.|:.::.:.|||| 
Human  1738 SAASVFSFSQPGFSSVPAFGQPASS---TPTSTSGSVF-----------GAASSTSSSSSFSFG- 1787

  Fly  1514 QSKPATTQNTGTFFFGQPTAVAPATPTNPSV---SSIFGAPATSTTASTSVSATTSTSTANAIAS 1575
            ||.|    |||...|||..  |||...:|..   .|:||    .|:|:|:.:||:..|...  ||
Human  1788 QSSP----NTGGGLFGQSN--APAFGQSPGFGQGGSVFG----GTSAATTTAATSGFSFCQ--AS 1840

  Fly  1576 SFAPTSTPQLFGNWGEKKTDLTTFG--ASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSS 1638
            .|..::|..:||.  ...|....||  :||.||:.    ||   :|:..:......|....||..
Human  1841 GFGSSNTGSVFGQ--AASTGGIVFGQQSSSSSGSV----FG---SGNTGRGGGFFSGLGGKPSQD 1896

  Fly  1639 ASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAATTPAG------GNAALTGLFGNV 1697
            |:. ..|...:|..||       :|:||.||..||:   :.|.|..|      |....||.|.:.
Human  1897 AAN-KNPFSSASGGFG-------STATSNTSNLFGN---SGAKTFGGFASSSFGEQKPTGTFSSG 1950

  Fly  1698 GNSLA--GVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAP 1760
            |.|:|  |.|...........|||   :||:| |....:|.||.   :|:.| .|||..:||.: 
Human  1951 GGSVASQGFGFSSPNKTGGFGAAP---VFGSP-PTFGGSPGFGG---VPAFG-SAPAFTSPLGS- 2006

  Fly  1761 ALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNN 1825
              .|...||..||   |||:..|.||||:|    ..||   |:.||..||... :.:..|:....
Human  2007 --TGGKVFGEGTA---AASAGGFGFGSSSN----TTSF---GTLASQNAPTFG-SLSQQTSGFGT 2058

  Fly  1826 PSGGDSHPRIFQFGSSQPAANNQFGGAGGATNNSA----GG 1862
            .|.|.|     .|||..       ||....:|||:    ||
Human  2059 QSSGFS-----GFGSGT-------GGFSFGSNNSSVQGFGG 2087

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Nup153NP_001097002.1 Nup153 <458..910 CDD:285770 112/542 (21%)
RanBP2-type Zn finger 864..883 CDD:275375 4/18 (22%)
zf-RanBP 903..931 CDD:279035 3/27 (11%)
RanBP2-type Zn finger 907..926 CDD:275375 2/18 (11%)
zf-RanBP 968..992 CDD:279035 6/25 (24%)
RanBP2-type Zn finger 968..987 CDD:275375 5/20 (25%)
zf-RanBP 1009..1038 CDD:279035 3/28 (11%)
RanBP2-type Zn finger 1013..1032 CDD:275375 0/18 (0%)
zf-RanBP 1072..1097 CDD:279035 3/24 (13%)
RanBP2-type Zn finger 1072..1091 CDD:275375 3/18 (17%)
zf-RanBP 1126..1155 CDD:279035 4/31 (13%)
RanBP2-type Zn finger 1130..1149 CDD:275375 2/18 (11%)
ZnF_RBZ 1239..1261 CDD:197784 3/21 (14%)
RanBP2-type Zn finger 1241..1260 CDD:275375 3/18 (17%)
NUP214NP_005076.3 WD40 repeat 39..91 CDD:293791
Seven-bladed beta propeller 41..404
WD40 <94..265 CDD:295369
WD40 repeat 96..144 CDD:293791
WD40 repeat 152..190 CDD:293791
WD40 repeat 196..230 CDD:293791
44 X 2 AA repeats of F-G. /evidence=ECO:0000305 236..1418 209/1097 (19%)
WD40 repeat 243..291 CDD:293791
WD40 repeat 304..350 CDD:293791
WD40 repeat 362..401 CDD:293791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..460
(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon). /evidence=ECO:0000269|PubMed:25410864 450..586
11 X 5 AA approximate repeats 481..2076 416/1848 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..536
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..700 24/107 (22%)
DUF2353 <733..938 CDD:286828 52/316 (16%)
Leucine-zipper 1 740..768 5/27 (19%)
Leucine-zipper 2 861..882 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 987..1009 3/25 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1152 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1213 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1234..1316 27/126 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1337..1408 24/161 (15%)
18 X 4 AA approximate repeats 1409..2084 212/767 (28%)
11 X 3 AA approximate repeats 1427..2085 205/750 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1438..1467 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1479..1539 10/68 (15%)
Periplasmic_Binding_Protein_Type_2 1598..>1674 CDD:304360 22/75 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1884..1903 4/19 (21%)
DUF1517 1904..>2022 CDD:295038 47/141 (33%)