DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and pom121

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_001353337.1	Gene:	pom121 / 568298	ZFINID:	ZDB-GENE-030131-6557	Length:	1201	Species:	Danio rerio

Alignment Length:	1324	Identity:	327/1324 - (24%)
Similarity:	471/1324 - (35%)	Gaps:	468/1324 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   818 MPNFLANPQPAAPIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQENCIPKPK-----INRKYT 877
            |.::||.|:.:.           ||..:|:..:.:|..|.  ...:|. :.:|.     .||:.:
Zfish   132 MGSYLAKPEESP-----------SAAVRPAGGSGSFMHPR--EQLRER-LARPNHAVHTPNRRLS 182

  Fly   878 FSAPA-PLDDLRITNKQSQP-------TINGTPSSKEWE----CDTCMVRNKPEINKCVACETAK 930
            |..|| ......||.::..|       .|...|.:| |:    .:....||.|.::..|..:.|:
Zfish   183 FGDPAGNASRFTITPQRHYPLQQTGTSPIGVMPPAK-WDGYRKKNILTQRNSPTVHSPVTVKIAR 246

  Fly   931 PVASAAP----VQAPLPPSTAAIDTQSFVGFGDRFKKSTTAWECDAC----MLSNKAEASKCIAC 987
            |.::.:.    :.:|...::..|..|:                 |.|    :||...|:.|....
Zfish   247 PDSTRSSFFNHLNSPGAVTSPGIGAQA-----------------DPCSREAVLSVLRESRKREVD 294

  Fly   988 ETPRKTVAPKVNN-------------FSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGA 1039
            |..:...:.:.:.             |.||:.|...::      ||              .|||
Zfish   295 EEDKSASSGQKSKRRRHDSSGSSQSAFEPLLANGAPSQ------LV--------------PKPG- 338

  Fly  1040 TMALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANS 1104
              :|....|.::...||:        |:|.|:        |..:.:...:....|.....|| .|
Zfish   339 --SLKRGMNSSLIEESIM--------KRSRTS--------SVSSISGAPVPSGVPGSVRNPI-RS 384

  Fly  1105 SYPSINNNLP---AGSGFDIS-FTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESAL 1165
            ||.| :...|   |.|...:| ||.....                  .||||...|:.:..|.|
Zfish   385 SYSS-SQGYPQRRAASSLSLSPFTSPGGS------------------RCQTPERAAKKAREEDA- 429

  Fly  1166 ISSISSSSASF------------SGSLSRPSSRSSSG-STSTCGSVCSG-------SIVSISSTT 1210
               .|.||.||            |.:.::.:.:|.:. :|||..|..||       .:|    ||
Zfish   430 ---TSPSSTSFAKTDKVAADPDPSPNTTKLTPKSEAPVATSTSDSGSSGGKRKRKIQLV----TT 487

  Fly  1211 ESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPA---- 1271
            .....:|   :||.|:.|:...|   |....|.:|.|:|...      ..|:..||...||
Zfish   488 NRGDQIS---LPPPPEVGYTITV---KDLDMEKKAALSKIQK------VLEEPEPEIPPPASEPA 540

  Fly  1272 ------------------ATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFG 1318
                              :|:..:.|:||.......|..|....|::  |||||||
Zfish   541 PAPVSAPTLSLFSQPAPISTSGTAPATSVVPSLLSLSTPKPETTPAI--TTTPAPT--------- 594

  Fly  1319 QSNQGKDVADSKKTEAPKTFMFGVSKVEEPKTVSFGTGIKETTATSSTEATAPTPAAAAPAPVQF 1383
                                                  |..|...|||.::||....::||....
Zfish   595 --------------------------------------IDLTITASSTASSAPLTLISSPAITTA 621

  Fly  1384 VFKAPTTATT--ASSLT-------------------TTISTTSNAPALGGFSFGAPSSSSTVSSS 1427
            ...|.||.:|  |||::                   |.:.||:.|||:...|..||::|...||.
Zfish   622 SLTAATTVSTAPASSISNPLLESLKNMKNNPLLTAPTLMGTTTAAPAVPVSSLSAPAASIIPSSG 686

  Fly  1428 TTSTSANPAAVKPMFSWSGAGSAVSS------TSSSQ----------QPVAKAPTLGFGVS---- 1472
            ...:.:.|.|::..||   |.|::||      ||...          ||.:...:||.|.|
Zfish   687 VVKSESGPTALQSSFS---APSSISSPAFKPATSMPSTFAQILAQPLQPPSTISSLGGGSSLFSL 748

  Fly  1473 ------------SSTV---TTTTTSTKVFAFTPASGLDP--AAATSAPAAGAGFSFGSQSKP--- 1517
                        .|||   |.|..|....:...:||..|  :||::.||:      ..:.||
Zfish   749 IKPVATPASEPPKSTVAAPTNTAASVNSISNPLSSGFKPIFSAASTTPAS------TPEVKPTQP 807

  Fly  1518 ------ATTQNTGTFFFGQ---PTAVAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAI 1573
                  .:|..:|...|||   ||...||.|.:.:.:.:||. .|||..:|             :
Zfish   808 TFKPLFGSTTISGVSAFGQTITPTTSTPAAPASQNSAMLFGG-LTSTQPTT-------------V 858

  Fly  1574 ASSFAP-TSTP--QLFGNWGEKKTDL----TTFGASSGSGTTTTPSFGWSSNGDAAKSNSAAVGS 1631
            .||.|| |.||  .|||.|....|..    .||...:.|.||.||         |..:|:|:|||
Zfish   859 PSSAAPATQTPSQSLFGKWSTPTTSAPATNPTFQFGATSTTTATP---------ALNTNTASVGS 914

  Fly  1632 --------AAVPSSSASTMATPIFGSSSM-----------FGPSSSSNNTTSTSTTSLPFGSAA- 1676
                    ||.|:::.....|..||..|.           ||.:|::..::...||...|||:.
Zfish   915 ANSAFQFGAAKPAAAPQAQNTFTFGQQSTNQNSTTTPFGGFGVTSNATTSSEAPTTQTTFGSSTF 979

  Fly  1677 TTAATTPAGGNAALTG----LFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVF 1737
            ||::..||....||..    .||..|              |::.|:|.|  ||  |..:.:||.|
Zfish   980 TTSSNFPASTPQALAAPKPFAFGAAG--------------ASSGASPFT--FG--TAASTSAPAF 1026

  Fly  1738 GSGS----------------TIPSAG--FGAPA-AAAPLAAPALPGAFNFGGATAATPAASSAPF 1783
            |:.|                |.|||.  |||.. .|||..|||  ..|.||||..|.  .::||
Zfish  1027 GTNSQPAFGGVSSGFSFGNTTTPSATPVFGATTQTAAPAPAPA--PTFTFGGAPTAN--QNTAP- 1086

  Fly  1784 VFGSSTNEPLAKPSFNFTGSAASST---APAPA-----FNFTANTAATNNPSGGDSHPRIFQFGS 1840
                ||..|.|...||| |::.|||   .||||     |:|.||..        ||.|   .||:
Zfish  1087 ----STPAPPASGGFNF-GASLSSTPFGTPAPAAQPQGFSFGANNT--------DSKP---AFGT 1135

  Fly  1841 SQPAANNQFGGAGGATNNSAGGMPMFNFSPGAPQMQSTPNANALFQFSATSTAPANIFAFNPPAA 1905
            |.||    ||.|       :.||.|...|||.|            .|.|.....|:.|..:|.:.
Zfish  1136 STPA----FGQA-------SPGMSMPFGSPGTP------------GFGAMGGLGASPFGASPASF 1177

  Fly  1906 GNSAQSSQTARRKIRAPVRRLPPR 1929
            .....:..:..|:::|  ||..||
Zfish  1178 SIGTGTKTSGARRLQA--RRQHPR 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	23/108 (21%)
		RanBP2-type Zn finger	864..883	CDD:275375	7/24 (29%)
		zf-RanBP	903..931	CDD:279035	7/31 (23%)
		RanBP2-type Zn finger	907..926	CDD:275375	5/22 (23%)
		zf-RanBP	968..992	CDD:279035	7/27 (26%)
		RanBP2-type Zn finger	968..987	CDD:275375	6/22 (27%)
		zf-RanBP	1009..1038	CDD:279035	3/28 (11%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	2/18 (11%)
		zf-RanBP	1072..1097	CDD:279035	2/24 (8%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	1/18 (6%)
		zf-RanBP	1126..1155	CDD:279035	4/28 (14%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	0/18 (0%)
		ZnF_RBZ	1239..1261	CDD:197784	4/21 (19%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	4/18 (22%)
pom121	NP_001353337.1	POM121	286..525	CDD:317613	67/317 (21%)
pom121	NP_001353337.1	Herpes_BLLF1	<599..1039	CDD:330317	134/489 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.030