Protein Alignment Nup153 and Pom121l2

DIOPT Version :10

• Sequence 1: NP_001097002.1
• Gene: Nup153 / 32630
• FlyBaseID: FBgn0061200
• Length: 1929
• Species: Drosophila melanogaster
• Sequence 2: NP_001156402.1
• Gene: Pom121l2 / 502128
• RGDID: 1594366
• Length: 917
• Species: Rattus norvegicus
• Alignment Length: 1062
• Identity: 228/1062 - (21%)
• Similarity: 348/1062 - (32%)
• Gaps: 323/1062 - (30%)

  Fly   903 SSKEWECDTCMVRNKP----------EINKCVACETAKPVASAAPVQAPL---PPSTAAIDTQSF 954
            ||.:...|.   |.||          ::::......|:||....|.:.|.   |.:.||..::::
  Rat    14 SSAQGRADP---REKPATRQPTRPLYQVHRVQHVHRAQPVRRHRPARRPPNWDPANPAAFVSEAW 75

  Fly   955 VGFGDRFKKS-------TTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSP--------- 1003
            ..|..:..::       :..||  :.:..|      ..:...||.|.:|.....||
  Rat    76 RRFPMKSPQNPIMGSLPSDWWE--SYLKRN------IWSLRHPRATWSPVTVKISPPERRPRPLF 132

  Fly  1004 ----LITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDR 1064
                ::.:|..:|.....|   .|.:|.:.: .|..|.||....|           :..|. .|.
  Rat   133 PASRVVNSAGPSEEPPGPC---GKEQVLRAL-LECRKGGARWEEP-----------LFPDS-SDT 181

  Fly  1065 FKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYP-SINNNLPAGSGFDISFTRKAN 1128
            .:||||.|.....:|                ||...::..:.| |:..:|.|
  Rat   182 QRKSATLWSAFKPLL----------------KSGATVSFVARPGSLKRSLHA------------- 217

  Fly  1129 MWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSIS----------------SSSASFS 1177
                       :|||.:|         .|:|.|..||::||.                |||...|
  Rat   218 -----------QSSDPKC---------KRSSYSSVALLASIHTRGPLSTKRNAITSSYSSSRDLS 262

  Fly  1178 GSLSRPSSRSS----------SGST---------STCGSVCSGSIVSISSTTESAKALSAKKVPP 1223
            .|..|..||||          :|.:         |:.|.: :|.|..:.|.......:..::.|
  Rat   263 ESWKRHFSRSSVQTPEWPLKKTGKSPNSHLLVTPSSSGQI-NGKIPLLQSGPRHLLTMPCQQGP- 325

  Fly  1224 KPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFG 1288
                     |..::..|.|.:|                  :|......||| .:|..|:|:.|.|
  Rat   326 ---------VVTEEDPTSEGQA------------------VPSNQTTEATT-GTATDSIPEIRAG 362

  Fly  1289 FSHVKEVVKPS---VETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKTFMFGVSKVEEPKT 1350
            |.....:.:||   :.|...|                  .:...|...||    .|.|.:|...:
  Rat   363 FQPPLSLNRPSETVLNTCVNP------------------QLESLKNMPAP----HGCSLLEHIPS 405

  Fly  1351 VSFGT--------GIKETTATSSTEAT----APTPAAAAPAPVQFVFKAPTTATTASSLTTTIST 1403
            :|..:        .:..:..|..|::|    .|....:|.:|...|. .||..||.|:|...:|:
  Rat   406 ISSDSKPSIASIQALPSSPTTPVTDSTWLSSVPQAHRSAVSPHSSVI-IPTAPTTQSTLVGVVSS 469

  Fly  1404 -------------TSNAPALGGFSFGA-------PSSSSTVS-----SSTTSTSANPAAVKPMFS 1443
                         ||...||... :|:       .:|.|.:|     ||::|.|..|..::|.|.
  Rat   470 PVLHLPASVLPVETSAHSALRPI-WGSVHNTKVRTASYSRISVMAEASSSSSFSTTPGILRPTFK 533

  Fly  1444 WSGAGSAVSSTSSSQQPVA-KAPTLGFGVSSSTV---TTTTTSTKVFAFTPAS-----GLDPAAA 1499
            ..........|.|...||: :.|:|.....|:.:   ..||....|.:..|||     |:|....
  Rat   534 PIFGSIEPLKTMSKTAPVSTQQPSLSLSSGSTHLFHSLATTVPCMVTSAIPASTSKDPGVDLNIV 598

  Fly  1500 T-------SAPAAGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPAT-PTNPSV-----------S 1545
            |       |.|:........||..|:.|.           .:.|:. ||.|:|           |
  Rat   599 TSTMGNSCSVPSCDTCLLGASQDFPSATD-----------LIFPSKHPTIPTVHTVTLFSQVLTS 652

  Fly  1546 SIFGAPATSTTASTSVS---ATTSTSTANAIASSFAPTSTPQLFGNWGEK-KTDLTTFGASSGSG 1606
            :|..:|...|.....||   ||..|||..:..:|.....|..|..:.|.. |.....|..|
  Rat   653 AIKISPLRGTDKPRRVSSPLATLDTSTNQSPVTSSISNVTSALTASLGSSPKPPFLPFQRS---- 713

  Fly  1607 TTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLP 1671
             |..||.|..   |..|..|..:    .|:.|              |..|..|.|:..:.|..||
  Rat   714 -TCQPSPGAI---DGLKQTSLQL----APAKS--------------FCTSFLSENSGVSPTQMLP 756

  Fly  1672 FGSAATTAATTPA-GGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAP 1735
            ......:..|.|| ||..:.|.:......|..|:|...|.:|.:.|::....:..........:.
  Rat   757 PAQLVLSKTTWPACGGLTSSTPIIRTPTISQPGLGGNPAGSPPSKASSIALRVVRQNHQSGTYSS 821

  Fly  1736 VFGSGSTIPSAGFGAPAAAAPLAAPAL----PGAFNFGGATAATPAASSAPFVFGSSTNEPLAKP 1796
            ||||.:..|.| ||....:.....|.:    |.....|...:.|| ::.||||  ...|..:..|
  Rat   822 VFGSTAPRPFA-FGGLVTSMDCGEPEVIVTAPPRSTSGARQSMTP-STLAPFV--QCWNWSMQGP 882

  Fly  1797 SFNFTGSAA------SSTAPAP 1812
            ....|..|:      .|.||.|
  Rat   883 PNQITPLASIPARKIMSGAPLP 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	RanBP2-type Zn finger	864..883	CDD:275375
		zf-RanBP	903..931	CDD:395516	7/37 (19%)
		RanBP2-type Zn finger	907..926	CDD:275375	4/28 (14%)
		zf-RanBP	968..992	CDD:395516	4/23 (17%)
		RanBP2-type Zn finger	968..987	CDD:275375	3/18 (17%)
		zf-RanBP	1009..1038	CDD:395516	6/28 (21%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	3/18 (17%)
		zf-RanBP	1072..1097	CDD:395516	2/24 (8%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	2/18 (11%)
		zf-RanBP	1126..1155	CDD:395516	4/28 (14%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	4/18 (22%)
		ZnF_RBZ	1239..1261	CDD:197784	3/21 (14%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	2/18 (11%)
Pom121l2	NP_001156402.1	POM121	162..341	CDD:464572	51/268 (19%)