DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and CG14712

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_650096.1	Gene:	CG14712 / 41397	FlyBaseID:	FBgn0037924	Length:	1266	Species:	Drosophila melanogaster

Alignment Length:	1627	Identity:	390/1627 - (23%)
Similarity:	540/1627 - (33%)	Gaps:	543/1627 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 QRRRFNASIYGSTSALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNN--RLFSRSNLSS 541
            :|||||.|   |.|.::||..:..|..|:..|   :|.|.:|.:..|.|:..|  |...||.::.
  Fly     2 ERRRFNMS---SMSPMADSTRIDASLLNNRPA---ASNFLRGLSPKGSNTSLNGTRTPERSLMNR 60

  Fly   542 SAASS------MLGLNSAGSSPAHQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPG 600
            ||.||      .|.|:.........:|:|     |...:.|        :|:|.|
  Fly    61 SATSSSTITRQKLNLSQVDPRTFADVHSS-----GLSSRIV--------ALSERS---------- 102

  Fly   601 TGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQRQGTPATPYLRSTSASRNVSVPNHI 665
             ||.. :|...||.    .||...:|..:|...::|.......|...|..||..:...:|
  Fly   103 -GLQR-SMSASNLY----NPLTQPRRAPASPLPYKSRAPTLSITQIAPPERSFYSGNTLS----- 156

  Fly   666 NELAELRSNKL--LVP--TMQQLLERRR-------------------LHRVTQNSRDVVHSQNVR 707
               :.||||.|  |||  |.|:.|.|..                   |..:.:.||..:::::.:
  Fly   157 ---SLLRSNSLVGLVPKTTEQEQLSRENRPILHPPHPQHESEPTRSVLEELKEISRKRINTEDTQ 218

  Fly   708 AGGENNQEKPKPTAPYVAPIDQSANHTQHTNKMRSRLSHQTRNKETRTAEEEAPPPLDLPQISFP 772
            ...:..:...:....:|   |..|:|.|. .|:|: |..|......|..|.....||.....|.
  Fly   219 QAQDYTKRSCQQNVDFV---DFVAHHRQQ-QKLRN-LQQQQNQSFKRQRELTVSVPLRHHSTSL- 277

  Fly   773 DMASAPKFDLIIKPTVPVVSKPSTTDPIQSSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFA-A 836
                                  |...|.....:||..:|.|.|         |:..|...|.: :
  Fly   278 ----------------------SAASPALQHMNSNGTISPTQS---------PEQVAKRPNCSYS 311

  Fly   837 NGNVSAISKPSKRT-----------FTFSEPTPLS-------NFQENCIPKPKINRKYTFSAPAP 883
            |...|::|...:.:           |..|:...|:       |..||.   .||.||
  Fly   312 NDITSSLSSSCRHSNKRKLLDMRERFQHSKNDTLASGGSSPENSPENV---AKIQRK-------- 365

  Fly   884 LDDLRITNKQSQP--TINGTPSSKEWECDTCMVRNKPEINKCVACETAKPVASAAPVQAPLPPST 946
            :|...::...|.|  |:...|:|:        ..:.|.|.|.|...|.||
  Fly   366 VDAEAVSKAMSMPVVTVAAVPASR--------AISAPAIQKAVPQVTEKP--------------- 407

  Fly   947 AAIDTQSFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSN 1011
                            |.|         |.| |..|:.|| |.||..::      ||
  Fly   408 ----------------KLT---------LFN-ARQSQTIA-EQPRPDLS------SP-------- 431

  Fly  1012 EWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDA 1076
                       :|:..:....:..||....::.|..|     ||:      :|..|:..     |
  Fly   432 -----------EVDAGEYAGIQFVKPKQQNSMLAAKN-----PSV------ERTHKTKL-----A 469

  Fly  1077 CMLSN-KAEASKCIACETPRKSSTPIANSSYPSINNNLPAGSGFDISFTRKANMWECQTCLVMNK 1140
            .|||. |.|    :....|.:...|...|:...:....|.
  Fly   470 IMLSGLKGE----LYLGEPDELDAPAPKSAPAPVTLPTPV------------------------- 505

  Fly  1141 SSDEECIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCSGSIVS 1205
                :.|......:......|.:.:.:|..|.....|..:.:|:...::.||.:...:..|
  Fly   506 ----KPIIIAPVTTSTTTVTSTATISTSAPSKPIILSNQVIKPADVPNTNSTGSVPKLVLG---- 562

  Fly  1206 ISSTTESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNP 1270
                 :.|.....::.||||   ..::.|||..                         :|..|..
  Fly   563 -----QPAPPAKTEQTPPKP---IDKVPAAQAD-------------------------IPPKFEL 594

  Fly  1271 AATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSA-QFSFGFGQSNQGKDVADSKKTEA 1334
            :......|.||.|...||                ||..|:| .||||...:.....:|:...|..
  Fly   595 STKPVTPATSSQPLISFG----------------TPKSTAAPSFSFGSATNTTSSTIANITNTTT 643

  Fly  1335 PK-TFMFGVSKVEEPKTVSFGTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLT 1398
            .| .|.||.:....| ||...:|.| |.|.::|..:...|.....:...|....|.|.||.:. |
  Fly   644 SKPIFSFGQTPANGP-TVGGLSGFK-TEAPATTSVSTTNPGTQVTSTTTFGVTPPKTTTTVAP-T 705

  Fly  1399 TTISTT--SNAPALGG--------FSFGAPSSSSTVSSST-TSTSANPAAVKP-MFSWSGAGSAV 1451
            ||:|..  ...|:.|.        ||||   .|:.:||.| |:..::.||.|| :||:.|
  Fly   706 TTVSLNFGQPMPSFGAADTGVKPMFSFG---KSNNLSSGTPTTNGSDAAAAKPAVFSFGG----- 762

  Fly  1452 SSTSSSQQPVAKAPTLGFG----------VSSSTVTTTTTSTKVFAFTPASGLDPA-------AA 1499
                |:.||.|.|||..||          .|.....:.||...:|. ...:||..|       ||
  Fly   763 ----STTQPAAAAPTPVFGSLSKPLGEGFASPGANKSETTKPSIFG-NLDNGLGNAMKSSTNVAA 822

  Fly  1500 TSAPAAGAGFSFGSQSKPATTQNTGT--FFFGQPTAVAPATPTNPSVSSIFGAPATSTTASTSVS 1562
            |:|......|.|.:.:..|...:|.|  |.||.......|.|...|..::||..||:||......
  Fly   823 TTAAELPKPFGFAATTTAAGGGSTATNLFSFGGTATSKAAEPAPASQKNLFGLNATTTTPFAFGG 887

  Fly  1563 ATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGSGTTTTPSFGWSSNGDAAKSNSA 1627
            |     .|.|...|....:.|..|           .|||.:.| ....|| |..|.|...||...
  Fly   888 A-----AAGAADKSENKDNKPIAF-----------AFGAGNNS-AVANPS-GVFSFGGTDKSAPP 934

  Fly  1628 AVGSAAVPSSSASTMATP---IFGSSS-------MFGPSSSSNNTTSTSTTSLPF---GSAATTA 1679
            |.||.....:||:  |||   .||.|:       |||..|:..::|.....:.||   |.|.||.
  Fly   935 AFGSGTTSVTSAT--ATPTNNTFGFSTTQKPATPMFGSGSTQQSSTPAVAATKPFTLGGGAPTTP 997

  Fly  1680 ATTPAGGN--------------AALTGLF--------------GNVGNSLAGVGAPV-----ATT 1711
            :.:||.|.              .|.|.||              ||.....|..|:|.     |||
  Fly   998 SASPASGGFSFSAVATKNTTAPTAGTNLFGSPASASKPSFNFGGNTATQAAAAGSPAGGFSFATT 1062

  Fly  1712 PAATAAAPLTNIFG----------------NPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAP 1760
            .....:|. ||:||                ||||    ||.||        ||||||||||
  Fly  1063 TKKEDSAS-TNMFGSPNTGVVKPNFSFSSNNPTP----APTFG--------GFGAPAAAAP---- 1110

  Fly  1761 ALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPS--------FNFTGSAASSTAPAPAFNF- 1816
                        .||....|.||.||:||  |.|.|.        .|...:..:.|.|:..|:|
  Fly  1111 ------------TATSTNQSKPFAFGAST--PAAAPQPPLGGNLFANAVSATQNQTKPSGVFSFG 1161

  Fly  1817 ----TANTAATNNPSGGDSHPRIFQFGS------SQPAANN--------QFGGAGGATNNSAGGM 1863
                ||.|.|.|.|         |.||.      :.|.:|.        .||||||....:..|.
  Fly  1162 AAKSTAGTTAGNAP---------FSFGGASAGGIASPPSNQGLNTAKPFSFGGAGGTPAPNVFGS 1217

  Fly  1864 PMFNFSPGAPQMQSTPNANALFQFSATSTA----PANIFAFNPPAAGNSAQSSQTARRKIRAPVR 1924
            |    :|..|  .|.|...  |.|...|.|    ..|:||..|.:            |.||...|
  Fly  1218 P----APAPP--ASNPTGG--FNFGGVSPAQQANAGNMFAPTPES------------RPIRKATR 1262

  Fly  1925 RL 1926
            ||
  Fly  1263 RL 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	108/482 (22%)
		RanBP2-type Zn finger	864..883	CDD:275375	6/18 (33%)
		zf-RanBP	903..931	CDD:279035	6/27 (22%)
		RanBP2-type Zn finger	907..926	CDD:275375	4/18 (22%)
		zf-RanBP	968..992	CDD:279035	8/23 (35%)
		RanBP2-type Zn finger	968..987	CDD:275375	5/18 (28%)
		zf-RanBP	1009..1038	CDD:279035	2/28 (7%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	1/18 (6%)
		zf-RanBP	1072..1097	CDD:279035	7/25 (28%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	6/19 (32%)
		zf-RanBP	1126..1155	CDD:279035	1/28 (4%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	1/18 (6%)
		ZnF_RBZ	1239..1261	CDD:197784	0/21 (0%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	0/18 (0%)
CG14712	NP_650096.1	Nucleoporin_FG2	954..>1180	CDD:292589	77/265 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100