Protein Alignment Nup153 and POM121L12

DIOPT Version :10

• Sequence 1: NP_001097002.1
• Gene: Nup153 / 32630
• FlyBaseID: FBgn0061200
• Length: 1929
• Species: Drosophila melanogaster
• Sequence 2: NP_872401.3
• Gene: POM121L12 / 285877
• HGNCID: 25369
• Length: 296
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 56/312 - (17%)
• Similarity: 98/312 - (31%)
• Gaps: 94/312 - (30%)

  Fly   823 ANPQPAAPIVNFAANG-----NVSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRK----YTF 878
            |.|..:|.:.||...|     ...|::.|..|:.:..:.||....:::..|...:.:.    :.:
Human     4 AAPAESADLGNFWKAGEPLLQGPDALAAPMSRSPSTPQTTPSPQGRQSPWPLRSLTQSHIQYFQW 68

  Fly   879 SAPAP---LDDLRITNKQSQP----------------TINGTPSSKEWE-C---DTCMVRNKPEI 920
            ..|.|   |.::|.|...::|                |..|...|..|| |   ..|...|....
Human    69 GRPVPSTHLIEVRPTQDPAKPQRVVSEGWRRPALPGETALGRDLSCAWEGCMKGGLCRAWNPGRT 133

  Fly   921 NKCVACETAKPVASAAPVQAP--------LPPSTAAID---TQSFVGFGDRFKKSTTAWECDACM 974
            ...|....|.|....:|.::|        .|.:...:|   .::.:|...:..|.:..::.....
Human   134 WSPVTIGIAPPERQESPWRSPGQRARPAGRPAAQELLDPCTRETLLGALSQCPKGSARFDGPLWF 198

  Fly   975 LSNKAEASKCIACETPRKTVAPKVNNFSPLITNA--------------KSNEWECSVCLVRNKVE 1025
            ..:.::..        |:.:.|:.:.|.||..|.              ....|..|.
Human   199 EVSDSKGG--------RRNLQPRPSAFKPLSKNGAVASFVPRPGPLKPSLGPWSLSF-------- 247

  Fly  1026 VSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDAC 1077
                  |:.|.| :.:..||        ||.|.|.:      .||...|.:|
Human   248 ------CDDAWP-SVLVQPA--------PSAIWDFW------EATTPSCGSC 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	RanBP2-type Zn finger	864..883	CDD:275375	2/22 (9%)
		zf-RanBP	903..931	CDD:395516	8/31 (26%)
		RanBP2-type Zn finger	907..926	CDD:275375	6/22 (27%)
		zf-RanBP	968..992	CDD:395516	0/23 (0%)
		RanBP2-type Zn finger	968..987	CDD:275375	0/18 (0%)
		zf-RanBP	1009..1038	CDD:395516	4/28 (14%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	2/18 (11%)
		zf-RanBP	1072..1097	CDD:395516	2/6 (33%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	2/6 (33%)
		zf-RanBP	1126..1155	CDD:395516
		RanBP2-type Zn finger	1130..1149	CDD:275375
		ZnF_RBZ	1239..1261	CDD:197784
		RanBP2-type Zn finger	1241..1260	CDD:275375
POM121L12	NP_872401.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..162		4/19 (21%)
		POM121	193..>240	CDD:464572	6/54 (11%)