DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and Nup153

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_001093940.1	Gene:	Nup153 / 25281	RGDID:	3216	Length:	1468	Species:	Rattus norvegicus

Alignment Length:	1763	Identity:	447/1763 - (25%)
Similarity:	686/1763 - (38%)	Gaps:	532/1763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 TGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNSLSSLPNHKRPSLIGKQTHRRDLTMDETG 356
            ||:...|.||                 :|||::|.:.|:      ||||
  Rat   107 TGSNTEEPST-----------------TSTASNYPDVLT------RPSL---------------- 132

  Fly   357 TGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRRSELSAAAGGCGDSQSESDMNE 421
                     |.:||                   |.:|:|:.....:.|.::.....|...|.:.|
  Rat   133 ---------HRSHL-------------------NFSVLESPALHCQPSTSSAFPIGSSGFSLVKE 169

  Fly   422 YHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTA--------AQQSHRNSTWSLNSLT 478
            ..|:...||.      ::.|....:.:..|.|.|....||:        |::||..|..:..| :
  Rat   170 IKDSTSQHDD------DNISTTSGFSSRASEKDIAVSKNTSLPPLWSPEAERSHSLSQHTAIS-S 227

  Fly   479 QRRRFNASIYGSTS-ALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNLSSS 542
            ::..||.|.:|:.| :|.:|.:|.       ::....||||.|:||:||
  Rat   228 KKPAFNLSAFGTLSTSLGNSSILK-------TSQLGDSPFYPGKTTYGG---------------- 269

  Fly   543 AASSMLGLNSAGSSP-----AHQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTG 602
             |::.:..|...|:|     ..|:.|.......||:
  Rat   270 -AAAAVRQNKVRSTPYQAPVRRQMKAKQLNAQSYGV----------------------------- 304

  Fly   603 LSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQRQGTPAT-------------PYLRSTS 654
            .|:|..|||..||..|:||.||||:.|::....:|...|.|..:|             |.::...
  Rat   305 TSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDSTVFQAKKEKVDSQYPPVQRLM 369

  Fly   655 ASRNVSVPNHINELAELRSNKLLV--PTMQQLLERRRLHRVTQNSRDVVHSQNVRAGGENNQEKP 717
            ..:.||:          .:|:.:.  |::....:.|:.::........|..:|:   ...|:|:.
  Rat   370 TPKPVSI----------ATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKNI---SRQNREQE 421

  Fly   718 K----PTAPYVAPIDQSANHTQHTNKM-RSRLSHQTRNKETRTAEEEAPPPLDLPQISFP-DMAS 776
            .    |.....|....|:.......|| |.|.:|...:|.:.  |||...|| |||||.| ..:|
  Rat   422 SGFSYPNFSIPAANGLSSGVGGGGGKMRRERTTHFVASKPSE--EEEVEVPL-LPQISLPISSSS 483

  Fly   777 APKFDLIIKPTVPVVSKPSTTDPIQ--SSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGN 839
            .|.|: ...|.:...|. |:..|.|  |:|...|:|.:|         .||
  Rat   484 LPTFN-FSSPAISAASS-SSVSPSQPLSNKVQMTSLGST---------GNP-------------- 523

  Fly   840 VSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTINGTPSS 904
                      .||||.|. :.:.|.:.:|...|.  :|||.|....:|...|..|:..::.:.::
  Rat   524 ----------VFTFSSPI-VKSTQADVLPPASIG--FTFSVPLAKTELSGPNSSSETVLSSSVTA 575

  Fly   905 KEWECDTCMVRNKPEINKCVACE----TAK-------------PVASAAPVQAP-LPPSTA---- 947
            :    |..:|.:.....:...||    .||             |...:..|.:| |.|:|.
  Rat   576 Q----DNTVVNSSSSKKRSAPCEDPFTPAKILREGSVLDILKTPGFMSPKVDSPALQPTTTSSIV 636

  Fly   948 ----AIDT--QSFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACE----------------TP 990
                ||.|  .|.|.||:.. |:.::|:||.|:|.||...:|||||:                ||
  Rat   637 YTRPAISTFSSSGVEFGESL-KAGSSWQCDTCLLQNKVTDNKCIACQAAKLPLKETAKQTGIGTP 700

  Fly   991 RKTVAPKV-------NNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATM--ALPAT 1046
            .|:..|..       :.|.|.|     ..|:|..|||:||.|..||||||:.|||..:  |||.|
  Rat   701 SKSDKPASTSGTGFGDKFKPAI-----GTWDCDTCLVQNKPEAVKCVACETPKPGTGVKRALPLT 760

  Fly  1047 ----SNIAVATPSIITD---GFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANS 1104
                |.:..::.:.:|.   ||||:||:...:|||..|.:|||||.|:|::| |..|.....|:|
  Rat   761 VASESPVTASSSTTVTTGTLGFGDKFKRPVGSWECPVCCVSNKAEDSRCVSC-TSEKPGLVSASS 824

  Fly  1105 SYPSINNNLPAGS--GFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALIS 1167
            |.| :..:||:|.  |.| .|.:....|:|:.|||.||:...:||||::.....::........|
  Rat   825 SNP-VPVSLPSGGCLGLD-KFKKPEGSWDCEVCLVQNKADSTKCIACESAKPGTKSEFKGFGTSS 887

  Fly  1168 SISSSSASFSGSLSRPSSRSSSGSTSTCGSVCS-------GSIVSISSTTESAKALSAKKVPPKP 1225
            |::.:.::|...:  ||  ||||.:.|..|..:       |..:..||.:.|...::.....|||
  Rat   888 SLNPAPSAFKFGI--PS--SSSGLSQTFTSTGNFKFGDQGGFKLGTSSDSGSTNTMNTNFKFPKP 948

  Fly  1226 DAGFQ-QLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFGF 1289
            ...|: .::...|....:.:   :|||..:             |.|::..:| .|||.| |:||.
  Rat   949 TGDFKFGVLPDSKPEEIKND---SKNDNFQ-------------FGPSSGLSN-PASSAP-FQFGV 995

  Fly  1290 SHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKT-FMFGVSKVEEPKTVSF 1353
            |.:.:..|..    ..|..:||.||||.|.:|......|:..|...|: |.||
  Rat   996 STLGQQEKKE----ELPQSSSAGFSFGAGVANPSSAAIDTTVTSENKSGFNFG------------ 1044

  Fly  1354 GTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPAL-GGFSFGA 1417
                     |..|::.:.||         |.:|            ||.:...:|.|. |||:||.
  Rat  1045 ---------TIDTKSVSVTP---------FTYK------------TTEAKKEDASATKGGFTFGK 1079

  Fly  1418 PSSSSTVSSS------TTSTSANPAAVKPMFSWSGAGSAVSSTS-------SSQQPVAKAPTLGF 1469
            ..|::..|.|      |......|               |:|||       .:::|..: |...|
  Rat  1080 VDSAALSSPSMFVLGRTEEKQQEP---------------VTSTSLVFGKKADNEEPKCQ-PVFSF 1128

  Fly  1470 GVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPATTQNTG--TFFFGQPT 1532
            |.|..| ...::|...|:|:.|.   |:...|...|.|.|:||:|:...|.|...  .|.|...:
  Rat  1129 GNSEQT-KDESSSKPTFSFSVAK---PSVKESDQLAKATFAFGNQTNTTTDQGAAKPAFSFLNSS 1189

  Fly  1533 AVAPATPTNPSVSSIFGAPATSTTASTS--VSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTD 1595
            :.:.:||...|.:||||    |:|:|:|  |:|......:|.::||        .|||..|..|.
  Rat  1190 SSSSSTPATSSSASIFG----SSTSSSSPPVAAFVFGQASNPVSSS--------AFGNSAESSTS 1242

  Fly  1596 LTTFGASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSN 1660
            ........|...||                          ||:||  |.|.|    :||..:|||
  Rat  1243 QPLLFPQDGKPATT--------------------------SSTAS--AAPPF----VFGTGASSN 1275

  Fly  1661 NTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFG 1725
            :|.|:..|   ||:..|:::          :|.|                           .:||
  Rat  1276 STVSSGFT---FGATTTSSS----------SGSF---------------------------FVFG 1300

  Fly  1726 NPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSSTN 1790
            ......:|:|.||:..| |:  ||....|:.      |...:||..:::|     |.|..||
  Rat  1301 TGHSAPSASPAFGANQT-PT--FGQSQGASQ------PNPPSFGSISSST-----ALFSAGS--- 1348

  Fly  1791 EPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSHPRIFQFGSSQPAANNQFGGAGGA 1855
            :|:..|:|   |:.:||:.| |.|....:.:|..  ||..:...:||||||  ..|..|
  Rat  1349 QPVPPPTF---GTVSSSSQP-PVFGQQPSQSAFG--SGTANASSVFQFGSS--TTNFNF------ 1399

  Fly  1856 TNNSAGGMPMFNFSPGAPQMQSTPNANALFQFSATSTAPANIFAFNPPAAGN---SAQSSQTARR 1917
            |||:..|:..|..||..|...:.|:.:..|.|   |.:||   :|...:.|.   |:..:..:.|
  Rat  1400 TNNNPSGVFTFGASPSTPAAAAQPSGSGGFSF---SQSPA---SFTVGSNGKNMFSSSGTSVSGR 1458

  Fly  1918 KIRAPVRR 1925
            ||:..|||
  Rat  1459 KIKTAVRR 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	111/488 (23%)
		RanBP2-type Zn finger	864..883	CDD:275375	6/18 (33%)
		zf-RanBP	903..931	CDD:279035	6/44 (14%)
		RanBP2-type Zn finger	907..926	CDD:275375	2/18 (11%)
		zf-RanBP	968..992	CDD:279035	14/39 (36%)
		RanBP2-type Zn finger	968..987	CDD:275375	10/18 (56%)
		zf-RanBP	1009..1038	CDD:279035	15/28 (54%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	11/18 (61%)
		zf-RanBP	1072..1097	CDD:279035	13/24 (54%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	11/18 (61%)
		zf-RanBP	1126..1155	CDD:279035	11/28 (39%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	9/18 (50%)
		ZnF_RBZ	1239..1261	CDD:197784	3/21 (14%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	3/18 (17%)
Nup153	NP_001093940.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..128		5/20 (25%)
		Nup153	114..629	CDD:285770	121/551 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..222		7/49 (14%)
		29 X 2 AA repeats of F-G. /evidence=ECO:0000305	237..1411		338/1299 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..429		6/41 (15%)
		zf-RanBP	661..687	CDD:279035	7/25 (28%)
		RanBP2-type Zn finger	662..681	CDD:275375	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..714		6/20 (30%)
		zf-RanBP	722..750	CDD:279035	7/44 (16%)
		RanBP2-type Zn finger	725..744	CDD:275375	4/22 (18%)
		zf-RanBP	789..818	CDD:279035	13/51 (25%)
		RanBP2-type Zn finger	793..812	CDD:275375	9/34 (26%)
		zf-RanBP	846..875	CDD:279035	12/37 (32%)
		RanBP2-type Zn finger	850..869	CDD:275375	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..985		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1145		10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1209		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1260		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1308..1380		25/75 (33%)
		Nup_retrotrp_bd	1378..1468	CDD:287557	19/89 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1468		10/53 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352732
Domainoid	1	1.000	51	1.000	Domainoid score	I11337
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2708
OMA	1	1.010	-	-		QHG47406
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009548
OrthoInspector	1	1.000	-	-		oto96765
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23193
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5439
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000