DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup153 and Nup214

DIOPT Version :10

Sequence 1:NP_001097002.1 Gene:Nup153 / 32630 FlyBaseID:FBgn0061200 Length:1929 Species:Drosophila melanogaster
Sequence 2:NP_001395026.1 Gene:Nup214 / 227720 MGIID:1095411 Length:2086 Species:Mus musculus


Alignment Length:2090 Identity:469/2090 - (22%)
Similarity:711/2090 - (34%) Gaps:668/2090 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 LNYEE---VALADNIAEHDLAAEDEQTRRSEYNVFLLRKRAGAVAAAGGDEDEAEEDELEEDDED 198
            |:|.|   :.||.:.|..:::....|..::.:..:||.           |...||....::.|:.
Mouse   307 LSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLE-----------DSSRAELPVTDKSDDS 360

  Fly   199 ----------GDEEDDDEEQENL---------------------QQSAAVQTKRRRLEL------ 226
                      .:.|....|::.|                     .|:..|::..:.|||      
Mouse   361 LPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISTEGE 425

  Fly   227 ----------------ETPVNLPNMRRLPLLSSTPAAPLAAATSSS----SSQMYKGVSHIAPHR 271
                            :.|.||.    .|..:|:|..|::||.:|:    |:.....|....|  
Mouse   426 RQPKSSGSFPGTPSSPQAPQNLD----APATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGP-- 484

  Fly   272 RNHLNLYGSQRQREPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNSLSSLPNHK 336
             :......|.....|.|.  ||::::..:.|              .|:||.:....|..||.:  
Mouse   485 -SSFKSSASVTGEPPLYP--TGSDSSRAAPG--------------SGTSTFSFAPPSKGSLAS-- 530

  Fly   337 RPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRRS 401
            .|::....|.....|.   |..|.:.|..       :|.|.|.                      
Mouse   531 TPAVAPVATSAAPFTF---GFKPTLESTP-------MSSTPNT---------------------- 563

  Fly   402 ELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTAAQQS 466
                                         |::||         |..:..|.|...|...||...|
Mouse   564 -----------------------------GMKPS---------FPPSASSVKVNLNEKFTAVASS 590

  Fly   467 HRNSTWSLNSLTQRRRFNASIYGSTS-------ALSDSRLLSGSASNSG--SASASSSPFYQGRT 522
                              |.::.|||       :.|.....||..|:..  .||:||.|.   ::
Mouse   591 ------------------APVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPL---KS 634

  Fly   523 TFGGNSGNNRLFSRSNLSSSAASSMLGLNS---------AGSSPAHQLHASMT------------ 566
            :...:....|  |.....|||.|:  |..|         :|||.|..|...:|            
Mouse   635 SVSPSPAAGR--STQTAPSSAPST--GQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDP 695

  Fly   567 --GGIGYGMKAVDMRPSD-SGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESYSTPLIDAKRMG 628
              .|||..:........: ....|:..:..|.|::         |::|.      |...|.....
Mouse   696 VLAGIGEEIAHFQKELEELKARTAKACLQVGTSEE---------MKMLR------TESDDLHTFL 745

  Fly   629 SSIKEHQSSRQQRQGTPATPYLR---STSASRNVSVPNHINELAELRSNKLLVPTMQ-QLLERRR 689
            ..|:|...|......|..|..|.   ....:|.....||.:....|...:.|.|..: ||.|.||
Mouse   746 FEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRR 810

  Fly   690 LHR----VTQNSRDVVHSQNVRAGGENNQEKPKPTAPYVAP-----IDQSANHTQHTNKMRSRLS 745
            ||:    ..|:..||:..:     .:.:.|:.|.....:.|     .:..||:.:..|:.|.||:
Mouse   811 LHQYVKFAVQDVNDVLDLE-----WDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLN 870

  Fly   746 HQTRN-KETRTAEEEAPPPLDLPQISFPDMASAPKFD----LIIKPTVPVVSKPSTTDPIQSSKS 805
            ....: ::.|.....|  |..||. :....:::..||    .::|.|:...:|||...|      
Mouse   871 QLVDSLQQLRLYNHTA--PWSLPS-ALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVP------ 926

  Fly   806 SNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSAISKPSKRTF-TFSEPTPLSNFQENCIPK 869
              ..||.....|:.||||..:  .|.|...|..::|..:..|:|.: ...|.:..|:..:     
Mouse   927 --GKLSPAKQAQLRNFLAKRK--TPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQ----- 982

  Fly   870 PKINRKYTFSAPAPLDDLRITNKQSQPTING---TPSSKEWECDTCMVRNKPEINKCVACETAKP 931
                       |...:|.|.|.......:.|   .|..||.|....:.|:.|.:      .|...
Mouse   983 -----------PLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVV------RTPSI 1030

  Fly   932 VASAAPVQAP------LPPSTAAIDTQSFVGFGDRFKKSTTAWE-----CDACMLSNKAEASKCI 985
            ..|..|...|      :..|:.|:.:.:.         ||:|.:     .|:.||:.|....   
Mouse  1031 QPSLLPQSMPFAKPHLIHSSSPAVMSSAV---------STSATKVIPQGADSTMLATKTVKH--- 1083

  Fly   986 ACETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIA 1050
            ....|..|||      :|          :.:......:...|:..|..:........:|...|:.
Mouse  1084 GAPGPSHTVA------AP----------QAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQ 1132

  Fly  1051 V--ATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPS---IN 1110
            .  :.||..:...|...:.|                     |.:||....||:|||....   ||
Mouse  1133 ELRSNPSPPSAAMGSAVQHS---------------------AAKTPHAVLTPVANSQAKQGSLIN 1176

  Fly  1111 NNLPAGSGFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSISSSSAS 1175
            :..|:|          .....||.      ||.::.:...|       :.:|||     ::|:.|
Mouse  1177 SFKPSG----------PTAASCQL------SSGDKAVGQGT-------AKTESA-----ATSTPS 1213

  Fly  1176 FSGSLSRPSSRSSSGSTSTCGSVCSGSIVSISSTTESAKALSAKKVPPKPDA--------GFQQL 1232
            .:|.|::|.|.:|.| |.|.|::   :....||.|.:..|....|.|.:.:|        .|.:.
Mouse  1214 AAGQLNKPFSFASPG-TFTFGTI---TPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEA 1274

  Fly  1233 VAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAA---TTANSAASSV--PKFRFGFSHV 1292
            :.....:|....|     ..:..|....|...|.:..|||   ||.:||:|.:  |..:.|    
Mouse  1275 IPGNSPATGATSA-----PSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLG---- 1330

  Fly  1293 KEVVKPSVETTTTPAPTSAQFS-FGFGQSNQGKDVADSKK--TEAPKTFMFGV-----SKVEEPK 1349
             |::.||    :....|...|| ...||:.      ||.|  ::|..|.:.|.     |.|..|.
Mouse  1331 -ELLFPS----SLAGETLGSFSGLRVGQAE------DSTKPVSKASSTNLAGAQPAKPSGVSFPN 1384

  Fly  1350 TVSFGTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPALGG-- 1412
            |...|..: |...|||.     :||.||||....|..:.::||...|:..|.:......:.||  
Mouse  1385 TSVLGKPV-EPAVTSSV-----SPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLISFGGAA 1443

  Fly  1413 -------FSFG-APSSSSTVSSST-TSTSANPA--AVKPMFSWSGAGSAVSSTSSSQQPV----- 1461
                   |||| ..:||||.||:| ||||..|:  |..|..|:   |..:||.|:|..||     
Mouse  1444 LASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSF---GGLLSSPSASSLPVSSGKS 1505

  Fly  1462 ---AKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGL---DPA-----------AATSAPAAGAGF 1509
               |..|.:.....||.|:.||.|..|...:..:.|   ||.           ::.|.||:.|.|
Mouse  1506 TEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASF 1570

  Fly  1510 SFGSQSKPATTQNTGTFFFGQP----TAVAPATPTNPSVSSIFGAP-----ATST-----TASTS 1560
            ...::|.|.|        .|.|    .||:||        |.|..|     ||:.     :|:|.
Mouse  1571 VASTESMPVT--------LGAPDSKIEAVSPA--------STFAGPGQAAVATAVLPGAGSAATE 1619

  Fly  1561 VSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFG-ASSGSGTTTTPSFGWSSNGDAAKS 1624
            .|.|.:|||    .||.:|||.           |:...|| |:|||...|.|        .||.|
Mouse  1620 ASGTPTTST----VSSSSPTSA-----------TETAVFGTATSGSSVFTQP--------PAASS 1661

  Fly  1625 NSA----AVGSAAVPSSSASTMATPIFG--SSSMFGPSSSSNNTTSTSTTSLPFGSAA------T 1677
            :||    :..:|..||      |||:||  ::|:...::::...:|:...|..||::|      |
Mouse  1662 SSAFSQLSSNTATAPS------ATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQT 1720

  Fly  1678 TAATTPAGGNAA---LTGL-FGNVG-NSLAGVGAPVATTPAATAAAPLTNIFG------------ 1725
            ....|||.|.|.   .:|. |...| :|:...|..|::|||:|:|    |:||            
Mouse  1721 AFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSA----NVFGATSSTSSPGSFS 1781

  Fly  1726 ---------------NPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPA-------------- 1761
                           |..|....:|.||.||::    ||..:|....|||:              
Mouse  1782 FGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSV----FGGTSATTSTAAPSGFSFCQASGFGSSN 1842

  Fly  1762 ----LPGAFNFGGATAATPAASSAPFVFGSS----------------TNEPLAKPSFNFTGSAAS 1806
                ...|.|.||:.....:::|:..||||.                :.:...|..|:..|....
Mouse  1843 TGSVFGQAANTGGSVFGQQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFG 1907

  Fly  1807 STAPAPAFNFTANTAATNNPSGGDSHPRIFQFGSSQPAANNQFGGA-------GGATNNSAGGM- 1863
            |||.....|...|:.|......|.|     .||..:||.....||.       |.:|.|..||. 
Mouse  1908 STAAPNTSNLFGNSGAKTFGGFGSS-----SFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFG 1967

  Fly  1864 --------PMFNFSP---GAPQMQSTP--------NANALFQFSATSTAPANIFAFNPPAAGNSA 1909
                    |.|..||   |.|...|.|        ....:|. ..|:.|.|..|.|.  ::||:|
Mouse  1968 AAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFG-EGTAAASAGGFGFG--SSGNTA 2029

  Fly  1910 Q----SSQTA 1915
            .    :||.|
Mouse  2030 SFGTLASQNA 2039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup153NP_001097002.1 RanBP2-type Zn finger 864..883 CDD:275375 1/18 (6%)
zf-RanBP 903..931 CDD:395516 6/27 (22%)
RanBP2-type Zn finger 907..926 CDD:275375 3/18 (17%)
zf-RanBP 968..992 CDD:395516 5/28 (18%)
RanBP2-type Zn finger 968..987 CDD:275375 4/23 (17%)
zf-RanBP 1009..1038 CDD:395516 2/28 (7%)
RanBP2-type Zn finger 1013..1032 CDD:275375 1/18 (6%)
zf-RanBP 1072..1097 CDD:395516 3/24 (13%)
RanBP2-type Zn finger 1072..1091 CDD:275375 0/18 (0%)
zf-RanBP 1126..1155 CDD:395516 5/28 (18%)
RanBP2-type Zn finger 1130..1149 CDD:275375 4/18 (22%)
ZnF_RBZ 1239..1261 CDD:197784 3/21 (14%)
RanBP2-type Zn finger 1241..1260 CDD:275375 2/18 (11%)
Nup214NP_001395026.1 WD40 repeat 39..86 CDD:293791
Seven-bladed beta propeller. /evidence=ECO:0000250 41..404 16/107 (15%)
WD40 <94..>265 CDD:441893
WD40 repeat 96..144 CDD:293791
WD40 repeat 152..190 CDD:293791
ANAPC4_WD40 155..>216 CDD:403945
WD40 repeat 196..230 CDD:293791
46 X 2 AA repeats of F-G. /evidence=ECO:0000250|UniProtKB:P35658 236..1430 285/1415 (20%)
WD40 repeat 243..291 CDD:293791
WD40 repeat 304..350 CDD:293791 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..469 10/49 (20%)
PHA03247 <428..698 CDD:223021 71/389 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..531 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..574 8/87 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..694 28/130 (22%)
Leucine-zipper 1 734..762 6/33 (18%)
Leucine-zipper 2 855..876 6/20 (30%)
PHA03247 <1016..1327 CDD:223021 81/402 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1134..1154 4/40 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1328 45/190 (24%)
Nucleoporin_FG2 1182..>1367 CDD:435043 55/236 (23%)
PHA03247 <1204..1612 CDD:223021 130/461 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1384 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1453..1474 13/20 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1495..1575 20/79 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1615..1636 10/24 (42%)
PPE <1645..1869 CDD:444372 63/245 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1763..1814 12/54 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1881..1900 1/18 (6%)
Nup214_FG 1913..1973 CDD:408399 16/64 (25%)
46. /evidence=ECO:0000305 2081..2082
Blue background indicates that the domain is not in the aligned region.

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