DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and Nup153

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_786925.2	Gene:	Nup153 / 218210	MGIID:	2385621	Length:	1462	Species:	Mus musculus

Alignment Length:	1828	Identity:	449/1828 - (24%)
Similarity:	655/1828 - (35%)	Gaps:	659/1828 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 EPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNSLSSLPNHKRPSLIGKQTHRRD 349
            :||     |:...|.||                 :|||::|.:.|:      ||||
Mouse   105 DPA-----GSNTEEPST-----------------TSTASNYPDVLT------RPSL--------- 132

  Fly   350 LTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRRSELSAAAGGCGDSQ 414
                            |.:||                   |.:|:|:.....:.|.::.....|.
Mouse   133 ----------------HRSHL-------------------NFSVLESPALHCQPSTSSAFPIGSS 162

  Fly   415 SESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTA--------AQQSHRNST 471
            ..|.:.|..|:...||.      ::.|....:.:..|.|.|....||:        |::||..|.
Mouse   163 GFSLVKEIKDSTSQHDD------DNISTTSGFSSRASEKDIAVSKNTSLPPLWSPEAERSHSLSQ 221

  Fly   472 WSLNSLTQRRRFNASIYGSTS-ALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFS 535
            .:..| :::..||.|.:|:.| :|.:|.:|.       ::....||||.|:||:||
Mouse   222 HTAIS-SKKPAFNLSAFGTLSTSLGNSSILK-------TSQLGDSPFYPGKTTYGG--------- 269

  Fly   536 RSNLSSSAASSMLGLNSAGSSP-----AHQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGG 595
                    |::.:..|...|:|     ..|:.|.......||:
Mouse   270 --------AAAAVRQNKVRSTPYQAPVRRQMKAKQLNAQSYGV---------------------- 304

  Fly   596 SKKPGTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQRQGTP--------------- 645
                   .|:|..|||..||..|:||.||||:.|::....:|...|.|..
Mouse   305 -------TSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDNTVFQAKKEKVDSQY 362

  Fly   646 ------ATPYLRSTSASRNVSVPNHINELAELRSNKLLVPTMQQLLERRRLHRVTQNSRDVVHSQ 704
                  .||...|.:.:|.|.....:....:||.....:......::.:.:.|  ||...
Mouse   363 PPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSISR--QNREQ----- 420

  Fly   705 NVRAGGENNQEKPKPTAPYVAPIDQSANHTQHTNKMRSRLSHQTRNKETRTAEEEAPPPLDLPQI 769
                  |:....|..:.|  |....|:.......|||...:|....|.....|.|||.   ||||
Mouse   421 ------ESGFSYPNFSIP--AANGLSSGVGGGGGKMRRERTHFVAPKPPENEEVEAPL---LPQI 474

  Fly   770 SFP-DMASAPKFDLIIKPTVPVVSKPSTTDPIQSS-----KSSNTNLSTTNSKQMPNFLANPQPA 828
            |.| ..:|.|.|..    :.||.|  ::..|:.||     |...|:|.:|.|   |.|..    :
Mouse   475 SLPISSSSLPTFSF----SSPVTS--ASPSPVSSSQPLPNKVQMTSLGSTGS---PVFTF----S 526

  Fly   829 APIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQ------------------------------ 863
            :|||    ....:|:..|:...||||.|...:.|.
Mouse   527 SPIV----KSTQAAVLPPASIGFTFSVPLAKTEFSGSNSSSETVLSSSAQDITAVNSSSYKKRSA 587

  Fly   864 --ENCIPKPKINRKYT---------FSAPAPLDDLRITNKQSQPTINGT---------------- 901
              |:.....||.|:.:         |::|      ::.:...|||...:
Mouse   588 PCEDPFTPAKILREGSVLDILKTPGFASP------KVDSPALQPTTTSSIVYTRPAISTFSSSGI 646

  Fly   902 ------PSSKEWECDTCMVRNKPEINKCVAC--------ETAKPVASAAPVQAPLPPSTAAIDTQ 952
                  .:...|:||||:::||...|||:||        ||||...:..|.::..|.||
Mouse   647 EYGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLPLKETAKQTGTGTPSKSDKPAST------ 705

  Fly   953 SFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSNEWECSV 1017
            |..||||:||.:...|:||.|::.||.||.||:|||||:.....
Mouse   706 SGTGFGDKFKPAIGTWDCDTCLVQNKPEAVKCVACETPKPGTGV--------------------- 749

  Fly  1018 CLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNK 1082
                 |..::..||.||       .:.|:|:..|.|.::   ||||:||:...:|||..|.:.||
Mouse   750 -----KRALTLTVASES-------PVTASSSTTVTTGTL---GFGDKFKRPVGSWECPVCCVCNK 799

  Fly  1083 AEASKCIACETPRKSSTPIANSSYPSINNNLPAGS--GFDISFTRKANMWECQTCLVMNKSSDEE 1145
            ||.::|::| |..|.....|:||.|: ..:|.:|.  |.| .|.:....|:|:.|||.||:...:
Mouse   800 AEDNRCVSC-TSEKPGLVSASSSSPA-PVSLSSGGCLGLD-KFKKPEGSWDCEVCLVQNKADSAK 861

  Fly  1146 CIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCS-------GSI 1203
            ||||::.....::........||::.:.::|...:  ||  ||||.:.|..|..:       |..
Mouse   862 CIACESAKPGTKSEFKGFGTSSSLNPAPSAFKFGI--PS--SSSGLSQTLTSTGNFKFGDQGGFK 922

  Fly  1204 VSISSTTESAKALSAKKVPPKPDAGFQ-QLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEA 1267
            :..||.:.|...::......||...|: .:::..|...       .|||
Mouse   923 LGTSSDSGSTNTMNTNFKFSKPTGDFKFGVLSDSKPEE-------VKND---------------- 964

  Fly  1268 FNPAATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKT 1332
                        :....|:||          |....|.|| :||.|.||.....|     ..||.
Mouse   965 ------------NKNDNFQFG----------SSSGLTNPA-SSAPFQFGVSTLGQ-----QEKKE 1001

  Fly  1333 EAPKTFMFGVSKVEEPKTVSFGTGIK-------ETTATSSTEATAPTPAAAAPAPVQFVFKAPTT 1390
            |.||:         .|...|||.|:.       :|||||..::.               |...|.
Mouse  1002 ELPKS---------SPAGFSFGAGVNNPPNAAIDTTATSENKSG---------------FNFGTL 1042

  Fly  1391 ATTASSLT-----TTISTTSNAPAL-GGFSFGAPSSSSTVSSS--------------TTSTS--- 1432
            .|.:.|:|     ||.:...:|||. |||:||...|||..|||              .||||
Mouse  1043 DTKSVSVTPFTYKTTEAKKEDAPATKGGFTFGKVGSSSLPSSSMFVLGRTEEKQQEPVTSTSLVF 1107

  Fly  1433 -----ANPAAVKPMFSWSGAGSAVSSTSSSQQP----------------VAKAPTLGFGVSSSTV 1476
                 :.....:|:||:   |::..:...|.:|                :||| |..||..::|.
Mouse  1108 GKKADSEEPKCQPVFSF---GNSEQTKDESSKPTFSFSVAKPSGKESEQLAKA-TFAFGNQTNTT 1168

  Fly  1477 TTTTTSTKVFAFTPASGLDPAAATSAPA-AGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPATPT 1540
            |....:..||:|..:|    ::::|||| :.:|..||| |..::......|.|||        .:
Mouse  1169 TDQGAAKPVFSFLNSS----SSSSSAPATSSSGGIFGS-STSSSNPPVAAFVFGQ--------AS 1220

  Fly  1541 NPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGS 1605
            ||..||.||..|.|   |||.|......:..|..||.||.::|.:||.           ||||.|
Mouse  1221 NPVSSSAFGNAAES---STSQSLLFPQESEPATTSSTAPAASPFVFGT-----------GASSNS 1271

  Fly  1606 -------GTTTTPSFGWSS----NGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSS 1659
                   |.|||.|...||    .|.:|.|.|.|.|:          ..||.||.|.    .:|.
Mouse  1272 VSSGFTFGATTTSSSSGSSFVFGTGHSAPSASPAFGA----------NQTPTFGQSQ----GASQ 1322

  Fly  1660 NNTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIF 1724
            .|..|       |||.:::.|...||.......:||.|.:|
Mouse  1323 PNPPS-------FGSISSSTALFSAGSQPVPPPIFGTVSSS------------------------ 1356

  Fly  1725 GNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSST 1789
                   :..||||.          .|:.:|            ||..|    |.:|:.|.|||||
Mouse  1357 -------SQPPVFGQ----------QPSQSA------------FGSGT----ANASSVFQFGSST 1388

  Fly  1790 NEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSHPRIFQFGS--SQPAANNQFGGA 1852
            .      :||||                     .|||||      :|.||:  |.|||:.|..|:
Mouse  1389 T------NFNFT---------------------NNNPSG------VFTFGASPSTPAASAQPSGS 1420

  Fly  1853 GGATNNSAGGMPMFNFSPGAPQMQSTPNANALFQFSATSTAPANIFAFNPPAAGNSAQSSQTARR 1917
            |           :|:||..........|...:|..|.||                      .:.|
Mouse  1421 G-----------VFSFSQSPASFTVGSNGKNMFSSSGTS----------------------VSGR 1452

  Fly  1918 KIRAPVRR 1925
            ||:..|||
Mouse  1453 KIKTAVRR 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	117/555 (21%)
		RanBP2-type Zn finger	864..883	CDD:275375	6/27 (22%)
		zf-RanBP	903..931	CDD:279035	15/35 (43%)
		RanBP2-type Zn finger	907..926	CDD:275375	10/18 (56%)
		zf-RanBP	968..992	CDD:279035	15/23 (65%)
		RanBP2-type Zn finger	968..987	CDD:275375	10/18 (56%)
		zf-RanBP	1009..1038	CDD:279035	5/28 (18%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	2/18 (11%)
		zf-RanBP	1072..1097	CDD:279035	11/24 (46%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	9/18 (50%)
		zf-RanBP	1126..1155	CDD:279035	11/28 (39%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	9/18 (50%)
		ZnF_RBZ	1239..1261	CDD:197784	3/21 (14%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	3/18 (17%)
Nup153	NP_786925.2	Nup153	114..625	CDD:285770	118/551 (21%)
		zf-RanBP	657..683	CDD:279035	7/25 (28%)
		RanBP2-type Zn finger	658..677	CDD:275375	6/18 (33%)
		zf-RanBP	718..746	CDD:279035	10/49 (20%)
		RanBP2-type Zn finger	721..740	CDD:275375	7/40 (18%)
		zf-RanBP	785..814	CDD:279035	15/28 (54%)
		RanBP2-type Zn finger	789..808	CDD:275375	10/18 (56%)
		zf-RanBP	842..871	CDD:279035	7/28 (25%)
		RanBP2-type Zn finger	846..865	CDD:275375	4/18 (22%)
		Nup_retrotrp_bd	1372..1462	CDD:287557	32/100 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849116
Domainoid	1	1.000	50	1.000	Domainoid score	I11564
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47406
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4945
SonicParanoid	1	1.000	-	-		X5439
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.030