Protein Alignment Nup153 and Nup153

DIOPT Version :10

• Sequence 1: NP_001097002.1
• Gene: Nup153 / 32630
• FlyBaseID: FBgn0061200
• Length: 1929
• Species: Drosophila melanogaster
• Sequence 2: XP_061510968.1
• Gene: Nup153 / 1272252
• VectorBaseID: AGAMI1_008764
• Length: 1408
• Species: Anopheles gambiae
• Alignment Length: 1766
• Identity: 398/1766 - (22%)
• Similarity: 633/1766 - (35%)
• Gaps: 568/1766 - (32%)

  Fly    29 EESEEEE--EEEDESS----------AGALRESDSNNSIMGKMKMRVSSILPASLSGWFSPSSKD 81
            :.|:|::  |||||.:          |..:.|:||:.|                       :|::
Mosquito    15 QRSQEDDDCEEEDEVTPTGRSGRPVLAATMEEADSDRS-----------------------NSRN 56

  Fly    82 GNDALSSPANLRQSQPRQSNGRLTTKRKRGRRRIMLAEVDADAADDLDDGSDAKGLNYEEVALAD 146
            ..:.::|.....|.|  ...|::.:.....     |:::..:|.:.:......:.....||.|:.
Mosquito    57 HTNTINSSTTSEQDQ--SLVGKIASNFLSN-----LSKLVRNAKEKIVSPKQGRNKRSLEVDLSG 114

  Fly   147 NIAEHDLAAEDEQTRRSEYNVFLLRKRAGAVAAAGGDEDEAEEDE---------LEEDDEDGDEE 202
            ......||||..:           |.|:..|.....:|:|.|::|         :|::.|:..:|
Mosquito   115 RQVREQLAAEPRK-----------RPRSSIVDKEEEEEEEGEDEEDQDRTERAVMEQEQEEYADE 168

  Fly   203 DDDEEQENLQQSA---AVQTKRRRL-ELETPVNLPNMRRLPLLSSTPAAPLAAATSSSSSQMYKG 263
            :|:|:.....::|   .:.|||||| |:|.              |..||||..:|....:..
Mosquito   169 NDEEQVSKAHRNARTYEMVTKRRRLHEVEL--------------SVAAAPLPRSTIGMRASR--- 216

  Fly   264 VSHIAPHRRNHLNLYGSQRQREPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNS 328
                ||.|       .|:..:...::.|.      ..||.:..:           :||...|.|:
Mosquito   217 ----APIR-------SSKHTQTDRFDRFV------AQTGRMERA-----------TSTVGQYRNA 253

  Fly   329 LSSLPNHKRPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNV 393
            .:.          |:.|.|..|    .|...:::|.:.:.....|..|
Mosquito   254 RND----------GRPTGRTSL----FGRPASVASSDSVFRPYSIHST----------------- 287

  Fly   394 IETKTRRSELSAAAGGCGD-----SQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQS-- 451
            :.|.|..|......|..|:     :.|:........:|.....|..:||.....     :||.
Mosquito   288 LPTATVTSGAEPEDGAAGEPARPFAASKFGQGLADASGRMTSFLGNAHYRQRME-----SLQRGA 347

  Fly   452 -SKSIFNRSNTAAQQSHRNSTWSLNSLTQRR-RFNASIYGSTSALSDSRLLSGSASNSGSASASS 514
             :|:.|:..:..|:..:  |:.|.:|::.|| .||.:::||.|:||..|:         ......
Mosquito   348 VAKAFFSSHDEPAKSLY--SSGSESSVSSRRPSFNRTLFGSVSSLSSGRI---------PPEYGG 401

  Fly   515 SPFYQGRTTFGGNSGNNRLFSRSNLSSSAASSMLGLNSAGSSPAHQLHASMTGGIGYGMKAVDMR 579
            ||||.|.|.:||.|....|.:...:..||                                   :
Mosquito   402 SPFYDGLTRYGGASAARTLATNVMVQRSA-----------------------------------Q 431

  Fly   580 PSDSGSL----AETSVG---QGGSKKP-GTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQS 636
            ||:|..:    |.|..|   :.|::.| ...:|:|:.|:.::|:::||    .|:.|..:.|.
Mosquito   432 PSNSTLVVRQDAATGTGRRREAGAEPPKAPEISSTSQRMRHILDTFST----NKKNGQPVPEQ-- 490

  Fly   637 SRQQRQGTPATPYLRSTSASRNVSVPNHINELAEL-----RSNKLLVP----TMQQLLERRRLHR 692
                        :|.::|..|         ||.||     ::|::..|    ...::||..::.|
Mosquito   491 ------------FLSNSSLGR---------ELDELIDRSKQTNRIAYPYPDVHSPRILEMLQIMR 534

  Fly   693 VTQNSRDVVHSQNVRAGGENNQEKPKPTA----PY---VAPIDQSANHTQHTNKMRSRLSHQTR- 749
             .|.|..:::        |..:..|:|.|    .|   :.|.|:.|:.::..|     |:.:||
Mosquito   535 -EQKSASILN--------EPVEYVPRPPAVPLMEYDVPLLPADRPASPSERRN-----LASETRP 585

  Fly   750 NKETRTAEEEAPPPLDLPQISFPDMASAPKFDLIIKPTVPVVSKPSTTDPIQSSKSSNTNLSTTN 814
            :.|...|.||....|..|..:...:...|:|     ...|:.|:|.|.:..:.:.:.|....|.:
Mosquito   586 SLEASKAPEELKQQLAHPLPNPEHLRGLPRF-----RWNPLSSQPVTAEVKRKAVNGNETTPTHD 645

  Fly   815 SKQMPNFLANPQPAAPIVNFAANG---------------------NVSAISKPSK-----RTFTF 853
            .::......:.:...........|                     .|..:.:.|.     :.|||
Mosquito   646 EQEQLVGAEDKRETEQQEQHEEAGEEHGESEEEAWDDTDLMEQEYEVKELCRSSTPIEGVQQFTF 710

  Fly   854 SEPTPLSNFQE-NCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTING-----TPSSKEWECDTC 912
            :.|..|....| ...|.|.|.  :||::||     |..::..:|....     ..|:.:|.||.|
Mosquito   711 ASPVALGEPMELEFNPSPTIT--FTFASPA-----RCLDQDFEPKARTFQELMAESAGKWVCDMC 768

  Fly   913 MVRNKPEINKCVACETAKPVASAAPVQAPLPPSTAAID----TQSFVGFGDRFKKSTTAWE---- 969
            |:.|:||..||:|||:||| ......|..||...|..|    |.|.:......||.....:
Mosquito   769 MIPNEPEQQKCMACESAKP-GKKPEQQLQLPAKNATHDSEPQTPSDLKLWLAMKKPVQQQQQPCA 832

  Fly   970 CDACMLSNKAE---------ASKCIACETP---------RKTV---------APKVNNFSPLITN 1007
            |::.....|.|         |:.....:||         :|.|         |..|.:|..|:..
Mosquito   833 CESAKPGKKPEQQLQPPAKNATHDSEPQTPSDLKLWLAMKKPVQQQQQPSSSAQPVRSFQELMAE 897

  Fly  1008 AKSNEWECSVCLVRNKVEVSKCVACESAKPG-------ATMALPATSNIAVATPSII-------- 1057
            : :.:|.|.:|::||:.|..||:||||||||       ...|..||.:....|||.:
Mosquito   898 S-AGKWVCDMCMIRNEPEQQKCMACESAKPGKKPEQQLQPPAKNATHDSEPQTPSDLKLWLAMKK 961

  Fly  1058 --------------TDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPI--ANSSY 1106
                          ...|.:...:||..|.||.||:.|:.|..||:|||:.:.:..|:  .....
Mosquito   962 PVQQQQQPSSSAQPVRSFQELMAESAGKWVCDMCMIRNEPEQQKCMACESAKPAKKPVQQQQQQQ 1026

  Fly  1107 PSINNNLPAGSGFDISFTRKANMWECQTCLVMNKSSDEECIACQT------PNSQ-----ARNSN 1160
            |..:...|..| |.......|..|.|..|::.|:...::|:||::      |..|     |:||:
Mosquito  1027 PLTSTTQPVRS-FQELMAESAGKWVCDMCMIRNEPEQQKCMACESAKPAKKPEEQQQHPPAKNSS 1090

  Fly  1161 SESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCSGSIVSISSTTESAKALSA----KKV 1221
            .:|...:||                                         |..|.|:|    .||
Mosquito  1091 QDSEPHTSI-----------------------------------------EWKKMLAADSPFSKV 1114

  Fly  1222 PPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMP--EAFNPAATTANSAASSVPK 1284
            |...| |||.:|...|.|||.|:.|.|:|.:....|:||||..|  .....|...|:.||..|||
Mosquito  1115 PELKD-GFQSIVEKMKASTWVCDTCTAQNPIEHGRCLCCEQDRPGGGGAGSAPGKASEAAVPVPK 1178

  Fly  1285 FRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKT---FMFGVSKVE 1346
            |.||.        ||....|....|:.        ..|.|:|..:..|..|..   |:||..
Mosquito  1179 FTFGM--------PSFTPNTAANSTTI--------DTQSKEVKAAGITSTPSRTGGFLFGAF--- 1224

  Fly  1347 EPKTVSFGTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPALG 1411
                    .|:...|:.|...|.||.| |.||.|.                             |
Mosquito  1225 --------NGVDRGTSNSVAPAPAPAP-ATAPVPA-----------------------------G 1251

  Fly  1412 GFSFGAPSSSSTVSSSTTSTSANPAAVKPMFSWSGAGSAVSSTSSSQQPVAKAPTLGFGVSSSTV 1476
            .||||||::|        |....|||           :.|...|||:      |:..|   ::|.
Mosquito  1252 LFSFGAPANS--------SHPCPPAA-----------AVVPEASSSK------PSFSF---TNTS 1288

  Fly  1477 TTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPAT-TQNTGTFFFGQPTAVAPATPT 1540
            ||.|::.:.|.| .||...|:|.:..|.|.:|.|...|.:.|| |..||              .:
Mosquito  1289 TTVTSAAQPFVF-GASPKVPSAVSFQPLANSGSSMAQQQQFATATSVTG--------------DS 1338

  Fly  1541 NPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGS 1605
            |.:.:|:||.|     :||.|:...:|::                  ||.| ...:..||..|..
Mosquito  1339 NAAPTSLFGLP-----SSTPVNFNFTTTS------------------NWAE-SNPVFQFGGKSQP 1379

  Fly  1606 GTTTTPSFGWS 1616
            ..:...|.|.|
Mosquito  1380 NPSAQISAGQS 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	RanBP2-type Zn finger	864..883	CDD:275375	7/19 (37%)
		zf-RanBP	903..931	CDD:395516	15/27 (56%)
		RanBP2-type Zn finger	907..926	CDD:275375	10/18 (56%)
		zf-RanBP	968..992	CDD:395516	6/45 (13%)
		RanBP2-type Zn finger	968..987	CDD:275375	4/31 (13%)
		zf-RanBP	1009..1038	CDD:395516	14/28 (50%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	8/18 (44%)
		zf-RanBP	1072..1097	CDD:395516	12/24 (50%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	9/18 (50%)
		zf-RanBP	1126..1155	CDD:395516	9/34 (26%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	5/18 (28%)
		ZnF_RBZ	1239..1261	CDD:197784	9/21 (43%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	6/18 (33%)
Nup153	XP_061510968.1	None