DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and Pom121

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_446074.2	Gene:	Pom121 / 113975	RGDID:	620680	Length:	1199	Species:	Rattus norvegicus

Alignment Length:	1283	Identity:	300/1283 - (23%)
Similarity:	436/1283 - (33%)	Gaps:	404/1283 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 PPPLDLPQISFPDMASAPKFDLIIKPTVPVVSKPSTTDPIQSSKSSNTNLSTTNSKQMPNFLANP 825
            ||...|||        .|:            .:|....|.:|..||:|          ...:.:.
  Rat   138 PPEPALPQ--------DPR------------DRPGRRPPSRSPPSSST----------AQRVHHV 172

  Fly   826 QPAAPIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSAPAPLDDLRIT 890
            .||.|          :.:.:||:|. ...:..|||:   ..:..|:  |:|      |:...:.:
  Rat   173 YPALP----------TPLLRPSRRP-PHRDCGPLSS---RFVITPR--RRY------PIQQAQYS 215

  Fly   891 NKQSQPTI--NG-------TPSSKEWECDTCMVRNKPEINKCVACETAKPVASAAPVQAPLP--- 943
            ...:.||:  ||       :..:....|....||..|..:|.              .::|:|
  Rat   216 LLGALPTVCWNGGHKKAVLSARNSRMVCSPVTVRIAPPDSKL--------------FRSPMPEQI 266

  Fly   944 -------PSTAAID--TQSFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACETPRK---TVAP 996
                   ||:.|.|  .:..|....:.||..|..|.|...|..:         |..|:   :...
  Rat   267 LSTTLSSPSSNAPDPCAKETVLNALKEKKKRTVAEEDQLHLDGQ---------ENKRRRHDSSGS 322

  Fly   997 KVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGF 1061
            ..:.|.||:.|.                    ..|....|||:
  Rat   323 GHSAFEPLVANG--------------------VPAAFVPKPGS---------------------- 345

  Fly  1062 GDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPSINNNLPAGSGFDISFTR- 1125
               .|:|..:...|..:  ||...:..::      |.|.......||.:.|....|   .|.||
  Rat   346 ---LKRSLASQSSDDHL--NKRSRTSSVS------SLTSTCTGGIPSSSRNAITSS---YSSTRG 396

  Fly  1126 KANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSG 1190
            .:.:|: ::....:..|.......|||...|:.:..|.....  |||||........|..:.:..
  Rat   397 VSQLWK-RSGPTSSPFSSPASSRSQTPERPAKKTREEEPCHQ--SSSSAPLVTDKESPGEKVTDP 458

  Fly  1191 STSTCGSVCSGSIVSISSTTESAK--ALSAKK-----VPPKPDAGFQQLVAAQKTSTWECEACLA 1248
            :|....|:.:......||.....|  .|.:::     :||.|:.|:.  :.|:..
  Rat   459 ATGKQQSLWTSPPTPGSSGQRKRKIQLLPSRRGDQLTLPPPPELGYS--ITAEDL---------- 511

  Fly  1249 KNDMSRKTCI-----CCEQMMPEAFNPAATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAP 1308
              ||.|:..:     ..|....:|..||..|  |.|:|.|     |:.....|.|:....:.|||
  Rat   512 --DMERRASLQWFNKVLEDKTDDASTPATDT--SPATSPP-----FTLTLPTVGPAASPASLPAP 567

  Fly  1309 TSAQFSFGFGQSNQGKDVADSKKTEA--------PKT-------------FMFGVSKVEEPKTVS 1352
            :|........:..:....:.|:..||        |||             .:...|...:|.|..
  Rat   568 SSNPLLESLKKMQESPAPSSSEPPEAATVAAPSPPKTPSLLAPLVSPLTGPLASTSSDSKPTTTF 632

  Fly  1353 FGTGIKETTATSSTEATAP----------TPAAAAPA--PVQFVFKAPTTATTASSLTTTISTTS 1405
            .|.. ..::||..|:..||          ||||.||:  |...:|...:...::|||.|.
  Rat   633 LGLA-SASSATPLTDTKAPGVSQAQLCVSTPAATAPSPTPASTLFGMLSPPASSSSLATP----- 691

  Fly  1406 NAPALGGFSF-----GAPSSSS-----TVSSSTTSTSANPA----------AVKPMFS------- 1443
             .||.....|     ..|.|.|     |.||:.|:|.|:.|          ..||:|.
  Rat   692 -GPACASPMFKPIFPATPKSESDNPLPTSSSAATTTPASTALPTTATATAHTFKPIFESVEPFAA 755

  Fly  1444 -------------------------WSGAGSAVSSTSSSQQPVAKAPTLGFGV--SSSTVTTTTT 1481
                                     .:|.|:|.|:.::.....|..|..||||  ::||.:|..:
  Rat   756 MPLSPPFSLKQTTAPATTAATSAPLLTGLGTATSTVATGTTASASKPVFGFGVTTAASTASTIAS 820

  Fly  1482 STKVFAFTPASGLDP-AAATSAPAAGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPATPTNPSVS 1545
            :::...|   .|..| .|::||||..:.|.||....||.:. .|| .|.|..|.:..|..:.|..
  Rat   821 TSQSLLF---GGAPPVTASSSAPALASIFQFGKPLAPAASV-AGT-SFSQSLASSAQTAASNSSG 880

  Fly  1546 SIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQL---FGNWGEKKTDLTTFGASSGSGT 1607
            ...|...|.|| |||..||||..|.     :|:.|.||..   |.  ...|..|.|:     .|.
  Rat   881 GFSGFGGTLTT-STSAPATTSQPTL-----TFSNTVTPTFNIPFS--ASAKPALPTY-----PGA 932

  Fly  1608 TTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPF 1672
            .:.|:||             |...|..|:      ..|.||||..||.|.:|
  Rat   933 NSQPTFG-------------ATDGATKPA------LAPSFGSSFTFGNSVAS------------- 965

  Fly  1673 GSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVF 1737
               |.:||..||....|....||.:..|.:..|.|.:|.||          ||:.|.|.:    |
  Rat   966 ---APSAAPAPAAFGGAAQPAFGGLKASASTFGTPASTQPA----------FGSTTSVFS----F 1013

  Fly  1738 GSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPSFNFTG 1802
            ||.:|   :||||.|                  ||..|..:.|:..:|||||..|     |.|.|
  Rat  1014 GSATT---SGFGAAA------------------ATTQTTHSGSSSSLFGSSTPSP-----FTFGG 1052

  Fly  1803 SAASSTAPAPAFNFTANTAATNNPSGGDSHPRIFQFGSSQPAANNQFGGAGGATNNSAGGMPMFN 1867
            |||  .|....|..:| |..|.:.||      .|.|||.|..........||:.:.:..|.|. .
  Rat  1053 SAA--PAGGGGFGLSA-TPGTGSTSG------TFSFGSGQSGTTGTTTSFGGSLSQNTLGAPS-Q 1107

  Fly  1868 FSPGAPQMQSTPNANALFQFSATST----APANIFAFNPPAAGNSAQS 1911
            .||.|..:.|||.:..:|..::|.|    |||       |..|.:..|
  Rat  1108 SSPFAFSVGSTPESKPVFGGTSTPTFGQSAPA-------PGVGTTGSS 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	29/157 (18%)
		RanBP2-type Zn finger	864..883	CDD:275375	3/18 (17%)
		zf-RanBP	903..931	CDD:279035	5/27 (19%)
		RanBP2-type Zn finger	907..926	CDD:275375	5/18 (28%)
		zf-RanBP	968..992	CDD:279035	4/23 (17%)
		RanBP2-type Zn finger	968..987	CDD:275375	3/18 (17%)
		zf-RanBP	1009..1038	CDD:279035	2/28 (7%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	0/18 (0%)
		zf-RanBP	1072..1097	CDD:279035	3/24 (13%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	3/18 (17%)
		zf-RanBP	1126..1155	CDD:279035	5/28 (18%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	2/18 (11%)
		ZnF_RBZ	1239..1261	CDD:197784	3/26 (12%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	3/23 (13%)
Pom121	NP_446074.2	Cisternal side. /evidence=ECO:0000255	1..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Pore side. /evidence=ECO:0000255	76..1199		300/1283 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..197		20/99 (20%)
		POM121	292..527	CDD:405826	57/316 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..328		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..509		38/205 (19%)
		PHA03247	<422..761	CDD:223021	82/368 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..631		23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..734		10/32 (31%)
		Nucleoporin_FG2	<911..1021	CDD:406391	44/168 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1061..1151		30/103 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1163..1199
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.030