DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and SYNJ2

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_003889.1	Gene:	SYNJ2 / 8871	HGNCID:	11504	Length:	1496	Species:	Homo sapiens

Alignment Length:	621	Identity:	154/621 - (24%)
Similarity:	258/621 - (41%)	Gaps:	145/621 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQTEASKTPKIPDSEPDGSKGKGKQQLE-----TYRVYVVTWNV--GSRFPDNISLR------H 52
            :..|....||:|       .|...::|.|     ..|:.:.||||  |.:|..|: ||      .
Human   502 LDSTALLVTPRI-------LKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNV-LRTAELTDW 558

  Fly    53 LLGLQDVTVDKDTKETNAHLPDIYALGLQE---------VNAQPQQQVLGLFKEDPWTHK-AKEL 107
            ||....::...|:::.::. .||:|:|.:|         |||....:.:       |..: .|.:
Human   559 LLDSPQLSGATDSQDDSSP-ADIFAVGFEEMVELSAGNIVNASTTNKKM-------WGEQLQKAI 615

  Fly   108 LRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIEAEFTRTGFGGIWGNKGAVSVRFTLYGCGLA 172
            .|::.|:.:.:.|:.|:.|.:|||..||..::|:..:..:||.||..||||||.:||..:.....
Human   616 SRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFC 680

  Fly   173 FVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYREIYDHDYVFWFGDLNFRLQGSDSSTEVREL 237
            |:.:||||....:.||.||||:|.:...:.:.  |.::.||||||.||.|:|:  ..:..||...
Human   681 FICSHLTAGQSQVKERNEDYKEITQKLCFPMG--RNVFSHDYVFWCGDFNYRI--DLTYEEVFYF 741

  Fly   238 VRDESQHEALIQRDQLYQVREKSQLAFQVLQERLPAFPPTFKFREGTSEYDLK---RRPAWTDRI 299
            |: ....:.|::.||| |:::.|...|:...|....|.||:|:..|::.||..   |.||||||:
Human   742 VK-RQDWKKLLEFDQL-QLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRV 804

  Fly   300 MY--AVQPLNRQPG------MQLSIE----------QCSYKSHPLYTISDHKPVTSDFTIKLYP- 345
            ::  ...|.::..|      ..|.::          ...|........|||:||.:...:::..
Human   805 LWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869

  Fly   346 NVRAPGVVFSPLSLWKIGDENTVEYHKQAEFDEGSNDWIGIFPSE-----YASLADY--VAYEYV 403
            :|.|...||..:|.::...:.||..:.|:...|..|:    ||.:     ..:|..|  :....:
Human   870 DVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNE----FPEDLRTELMQTLGSYGTIVLVRI 930

  Fly   404 NQAES-PSSSDSNHQPDPFETPSHHRRGRHHHRNRQRQRRHQEANAQELVR-------------- 453
            ||.:. .:.:||:......:......:|| ..:.|.:.:...:...:|::|
Human   931 NQGQMLVTFADSHSALSVLDVDGMKVKGR-AVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANS 994

  Fly   454 -----------LDFADDVE-LRHGEQYLLIYFRSTGVR-------------GVTSLAGVSG---- 489
                       ||:..:.: |...|.||:..|...||.             |.|:||..|.
Human   995 CLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPAL 1059

  Fly   490 ----------------------VFVAEKRHGSPHRT 503
                                  ..|.|.||.||.|:
Human  1060 TKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRS 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	103/348 (30%)
SYNJ2	NP_003889.1	Syja_N	61..342	CDD:280532
		EEP	530..861	CDD:294334	103/345 (30%)
		DUF1866	872..1008	CDD:286093	23/140 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1073		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1085..1166		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1405
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1427..1473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740