DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and Inppl1

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_075233.1	Gene:	Inppl1 / 65038	RGDID:	68396	Length:	1257	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	118/453 - (26%)
Similarity:	183/453 - (40%)	Gaps:	118/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KGKGKQQLE--TYRVYVVTWNVGS-RFPDNIS---LRHLLG--LQDVTVDKDTKETNAHLPDIYA 77
            |.|..:|.|  ...|::.|||:|| ..|.|::   ....||  |.:|||      |..|  |||.
  Rat   413 KNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTV------TIPH--DIYV 469

  Fly    78 LGLQEVNAQPQQQVLGLFKEDPWTHKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIE 142
            .|.|| |:...::.|.|.:..     .|| |.:.||..:..:.:..:.:::.|:.:|...:..:.
  Rat   470 FGTQE-NSVGDREWLDLLRGG-----LKE-LTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVS 527

  Fly   143 AEFTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYR 207
            ....:||.....||||||.|.|...|....||..|||:.:.....|.::|..||        |..
  Rat   528 TSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDIL--------RLL 584

  Fly   208 EIYDHD-----------YVFWFGDLNFRLQGSDSSTEVRELVR--DESQHEALIQRDQLYQVREK 259
            .:.|..           ::|||||||:||     ..:::|::.  ...:.|.|::.|||...|||
  Rat   585 SLGDRQLSAFDISLRFTHLFWFGDLNYRL-----DMDIQEILNYISRREFEPLLRVDQLNLEREK 644

  Fly   260 SQLAFQVLQERLPAFPPTFKFREGTSE-YDLKRR---------PAWTDRIMYAVQPLNRQPGMQL 314
            .::..:..:|.: :||||:::..|:.: |...::         |:|.|||::...|       :.
  Rat   645 HKVFLRFSEEEI-SFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYP-------ET 701

  Fly   315 SIEQCSYKSHPLYTISDHKPVTSDFTIKLYPNVRAPGVV---FSPLSLWKIGDENTV-------- 368
            .|...||........|||.||...|.:         ||.   .|...|.|..|:..:
  Rat   702 HIICNSYGCTDDIVTSDHSPVFGTFEV---------GVTSQFISKKGLSKTSDQAYIEFESIEAI 757

  Fly   369 -------------------EYHKQAEFDEGSNDWIGIFPSEYAS---------LADYVAYEYV 403
                               ||.|..|.|..|:|.|.....:::|         |||   .||:
  Rat   758 VKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYL 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	94/338 (28%)
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	94/338 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986
		SH3-binding	945..950
		NPXY motif	984..987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1115
		SAM_Ship2	1193..1255	CDD:188890
		SAM	1201..1257	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810