DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and INPP5K

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_057616.2	Gene:	INPP5K / 51763	HGNCID:	33882	Length:	448	Species:	Homo sapiens

Alignment Length:	491	Identity:	150/491 - (30%)
Similarity:	238/491 - (48%)	Gaps:	87/491 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GSKGKGKQQLETYRVYVVTWNVGSRFPDNISLRHLLGLQDVTVDKDTKETNAHLPDIYALGLQEV 83
            |.||:      ...::||||||.|..|. :.|..||.|.:         .|.:| |||.:||||:
Human     8 GPKGR------RLSIHVVTWNVASAAPP-LDLSDLLQLNN---------RNLNL-DIYVIGLQEL 55

  Fly    84 NAQPQQQVLGLFKE----DPWTHKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIEAE 144
            |:    .::.|..:    |.|:....::|....::.|...:|||:||.:|.:.||:.::|.:..:
Human    56 NS----GIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTK 116

  Fly   145 FTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYREI 209
            .|.||..|.|||||.|::...|||..::.:..||..|.....:|:|.:.:|||..:...:....|
Human   117 STPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNI 181

  Fly   210 YDHDYVFWFGDLNFRLQGSDSSTE-VRELVRDESQHEALIQRDQLYQVREKSQLAFQVLQERLPA 273
            .|||.:.||||:|||::  |.... |||.:::.. :..|.::||| .:.:|.....:..||....
Human   182 LDHDLIIWFGDMNFRIE--DFGLHFVRESIKNRC-YGGLWEKDQL-SIAKKHDPLLREFQEGRLL 242

  Fly   274 FPPTFKFREGTSEYDL---KRRPAWTDRIMYAVQPLNRQ----------PGMQLSIEQCSYKSHP 325
            ||||:||...:::||.   ||:|||||||::.   |.||          |....|:....|.||.
Human   243 FPPTYKFDRNSNDYDTSEKKRKPAWTDRILWR---LKRQPCAGPDTPIPPASHFSLSLRGYSSHM 304

  Fly   326 LYTISDHKPVTSDFTIKLYPNVRAPGVVFSPLSLWKIGDENTVEYHKQAEFDEGSNDWIGIFPSE 390
            .|.|||||||:..|.::|.|.|.||.:|..|..||.:.::..|.|...::|.....||||::...
Human   305 TYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVG 369

  Fly   391 YASLADYVAYEYVNQAESPSSSDSNHQPDPFETPSHHRRGRHHHRNRQRQRRHQEANAQELVRLD 455
            ...:.|||:|.:|..:: .|.||:.:|                                  |.:|
Human   370 LRDVNDYVSYAWVGDSK-VSCSDNLNQ----------------------------------VYID 399

  Fly   456 FADDVELRHGEQYLLIYFRSTGVRGVTSLAGVSGVF 491
            .::.....  :::||.|:.::    :.|:.|:|..|
Human   400 ISNIPTTE--DEFLLCYYSNS----LRSVVGISRPF 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	113/327 (35%)
INPP5K	NP_057616.2	EEP	14..320	CDD:382041	113/327 (35%)
		Catalytic. /evidence=ECO:0000255	16..318		112/323 (35%)
		Required for interaction with GPR78 and PAK1. /evidence=ECO:0000269\|PubMed:26940976	318..448		35/153 (23%)
		Required for ruffle localization	321..448		34/150 (23%)
		SKICH	331..431	CDD:375315	29/140 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146100
Domainoid	1	1.000	210	1.000	Domainoid score	I2816
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3579
Isobase	1	0.950	-	0	Normalized mean entropy	S4193
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336369at33208
OrthoFinder	1	1.000	-	-		FOG0001973
OrthoInspector	1	1.000	-	-		mtm8545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810