DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and INPPL1

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_024304269.1	Gene:	INPPL1 / 3636	HGNCID:	6080	Length:	1324	Species:	Homo sapiens

Alignment Length:	492	Identity:	123/492 - (25%)
Similarity:	191/492 - (38%)	Gaps:	152/492 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KGKGKQQLE--TYRVYVVTWNVGS-RFPDNIS---LRHLLG--LQDVTVDKDTKETNAHLPDIYA 77
            |.|..:|.|  ...|::.|||:|| ..|.|::   ....||  |.:|||      |..|  |||.
Human   434 KNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTV------TIPH--DIYV 490

  Fly    78 LGLQEVNAQPQQQVLGLFKEDPWTHKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIE 142
            .|.|| |:...::.|.|.:..     .|| |.:.||..:..:.:..:.:::.|:.:|...:..:.
Human   491 FGTQE-NSVGDREWLDLLRGG-----LKE-LTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVS 548

  Fly   143 AEFTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYR 207
            ....:||.....||||||.|.|...|....||..|||:.:.....|.::|..||        |..
Human   549 TSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDIL--------RLL 605

  Fly   208 EIYDHD-----------YVFWFGDLNFRLQGSDSSTEVRELVR--DESQHEALIQRDQLYQVREK 259
            .:.|..           ::|||||||:||     ..:::|::.  ...:.|.|::.|||...|||
Human   606 SLGDRQLNAFDISLRFTHLFWFGDLNYRL-----DMDIQEILNYISRKEFEPLLRVDQLNLEREK 665

  Fly   260 SQLAFQVLQERLPAFPPTFKFREGTSE-YDLKRR---------PAWTDRIMYAVQP--------- 305
            .::..:..:|.: :||||:::..|:.: |...::         |:|.|||::...|
Human   666 HKVFLRFSEEEI-SFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSY 729

  Fly   306 ----------------------LNR-QPGMQLSIEQCSYKSHPL-------YTISDHKPVTSDFT 340
                                  |.| :|  ::.|...|..|:||       ...|||.||...|.
Human   730 GQSLPDRVMGDLGWSPSGLCPNLGRWEP--RVGIFPLSPHSYPLSPGCTDDIVTSDHSPVFGTFE 792

  Fly   341 IKLYPNVRAPGVV---FSPLSLWKIGDENTV---------------------------EYHKQAE 375
            :         ||.   .|...|.|..|:..:                           ||.|..|
Human   793 V---------GVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFE 848

  Fly   376 FDEGSNDWIGIFPSEYAS---------LADYVAYEYV 403
            .|..|:|.|.....:::|         |||   .||:
Human   849 NDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	99/377 (26%)
INPPL1	XP_024304269.1	SH2_SHIP	17..119	CDD:198206
		EEP	446..793	CDD:321002	99/377 (26%)
		Atrophin-1	<965..1280	CDD:331285
		SAM_Ship2	1260..1322	CDD:188890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810