DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9784 and INPP5D

DIOPT Version :9

Sequence 1:NP_001259623.1 Gene:CG9784 / 32629 FlyBaseID:FBgn0030761 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_001017915.1 Gene:INPP5D / 3635 HGNCID:6079 Length:1189 Species:Homo sapiens


Alignment Length:545 Identity:131/545 - (24%)
Similarity:209/545 - (38%) Gaps:133/545 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 KGKGKQQLE--TYRVYVVTWNVGSR-FPDNISLRHLLGLQDVTVDKDTKETNAHLPDIYALGLQE 82
            |.|..:|.|  ...:::.|||:|:. .|..|:...|...|..|.| |:.:...|  |||.:|.||
Human   392 KNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRD-DSADYIPH--DIYVIGTQE 453

  Fly    83 VNAQPQQQVLGLFKEDPWTHKAKELLRNYDYVAVKT---EQMQGLLLSMFVRRQHVEHLQDIEAE 144
               .|       ..|..|....|..|:....|..||   ..:..:.:.:..:.:|...:..|..:
Human   454 ---DP-------LSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTD 508

  Fly   145 FTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYREI 209
            ..:||.....||||||.|.|...|..|.||.:|||:.......|.::|..||        |:..:
Human   509 NVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNIL--------RFLAL 565

  Fly   210 YD-----------HDYVFWFGDLNFR--LQGSDSSTEVRELVRDESQHEALIQRDQLYQVREKSQ 261
            .|           ..::|||||||:|  |...::.|.::::  .:.|:..|:..|||...| :.|
Human   566 GDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKI--KQQQYADLLSHDQLLTER-REQ 627

  Fly   262 LAFQVLQERLPAFPPTFKFREGTSE-------------YDLKRRPAWTDRIMYAVQPLNRQPGMQ 313
            ..|...:|....|.||::|...|.:             |:|   |:|.||:::...||       
Human   628 KVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNL---PSWCDRVLWKSYPL------- 682

  Fly   314 LSIEQCSYKSHPLYTISDHKP--------VTSDFTIKLYPNVRAPGVVFSPLSL----------W 360
            :.:...||.|......|||.|        |||.|..|     ..||.|.|...:          .
Human   683 VHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSK-----NGPGTVDSQGQIEFLRCYATLKT 742

  Fly   361 KIGDENTVEYH----------KQAEFDEGSNDWIGI-----FPSEYASLAD--YVAYEYVNQAES 408
            |...:..:|:|          ::.|.:|||...:.:     .|.....::|  |:..:::..:..
Human   743 KSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIK 807

  Fly   409 PSSSDSNHQPD-------------PFETP-SHHRRGRHHHRNRQRQRRHQEANAQELVRLDFADD 459
            .|.||.::...             |..|| :||.....|.:...:.:..|....::|.     |.
Human   808 SSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY-----DF 867

  Fly   460 VELRHGEQYLLIYFRSTGVRGVTSL 484
            |:....|        |:|.:.:.||
Human   868 VKTERDE--------SSGPKTLKSL 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9784NP_001259623.1 INPP5c_INPP5J-like 31..341 CDD:197328 94/347 (27%)
INPP5DNP_001017915.1 SH2_SHIP 1..102 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..132
SH3-binding 1 124..129
INPP5c_SHIP1-INPP5D 404..710 CDD:197334 90/339 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..906 5/23 (22%)
PHA03307 899..>1127 CDD:223039
NPXY motif 1 912..915
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..1189
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1016..1030
NPXY motif 2 1019..1022
SH3-binding 3 1040..1051
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146108
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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