DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and Ocrl

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_796189.2	Gene:	Ocrl / 320634	MGIID:	109589	Length:	900	Species:	Mus musculus

Alignment Length:	491	Identity:	137/491 - (27%)
Similarity:	209/491 - (42%)	Gaps:	131/491 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QTEAS--KTPK---------IPDSEPDGSKG----------KGKQQLETYRVYVVTWNVGSRFPD 46
            :.|||  :.||         :|:::....:|          |....::::|.:|.||||..:.||
Mouse   190 EKEASNKEQPKVTNTMRKLFVPNTQTGQREGLIKHILTKREKEYVNIQSFRFFVGTWNVNGQSPD 254

  Fly    47 NISLRHLLGLQDVTVDKDTKETNAHLPDIYALGLQEVNAQPQ-----QQVLGLFKEDPWT----- 101
            : ||...|            :.:.:.||||.:|.||::...:     :.|    ||..|:
Mouse   255 S-SLEPWL------------DCDPNPPDIYCIGFQELDLSTEAFFYFESV----KEQEWSLAVER 302

  Fly   102 ---HKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIEAEFTRTGFGGIWGNKGAVSVR 163
               .|||       |..|:..::.|::|.:|.|:...::::|:..|.|.||..|..||||.|:||
Mouse   303 GLPSKAK-------YRKVQLVRLVGMMLLIFARKDQCQYIRDVATETTGTGIMGKMGNKGGVAVR 360

  Fly   164 FTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYR----EIYDHDYVFWFGDLNFR 224
            |..:......|.:||.||....:.|.:|||.|.....:.|....    .|..||.|.|.||||:|
Mouse   361 FVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMTFSVPNQTVPQVNIMKHDVVIWLGDLNYR 425

  Fly   225 LQGSDSSTEVRELVRDESQHEALIQRDQLYQVREKSQLAFQVLQERLPAFPPTFKFREGTSEYDL 289
            |...|:| ||:.|:.....|: |::.||| .::...:.||....|....|.||:|:...|..:|.
Mouse   426 LCMPDAS-EVKSLINKNELHK-LLKFDQL-NIQRTQKKAFADFNEGEINFVPTYKYDSKTDRWDS 487

  Fly   290 K---RRPAWTDRIMYAVQPLNRQPGMQLSIEQCSYKSHPLYTISDHKPVTSDFTIKLYPNVRAPG 351
            .   |.|||.|||::          ..:::.|..|:||.....||||||::.|.|         |
Mouse   488 SGKCRVPAWCDRILW----------RGINVNQLHYRSHMELKTSDHKPVSALFHI---------G 533

  Fly   352 VVFSPLSLWKIGDENTVEYHKQAE-----FDEGSNDWIGIFPSEYASLADYVAYEYVN----QAE 407
            |        |:.||.  .|.|..|     .|...||::   ||...|..::. :|.|.    |.|
Mouse   534 V--------KVVDER--RYRKVFEDIVRIMDRMENDFL---PSLELSRREFF-FENVKFRQLQKE 584

  Fly   408 S----------------PSSSDSNH-----QPDPFE 422
            .                |..:||.:     :.:|||
Mouse   585 KFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	104/329 (32%)
Ocrl	NP_796189.2	PH_OCRL1	11..115	CDD:270182
		Clathrin box 1	73..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..201		4/10 (40%)
		5-phosphatase. /evidence=ECO:0000250	236..562		116/384 (30%)
		INPP5c_INPP5B	239..532	CDD:197327	104/329 (32%)
		ASH. /evidence=ECO:0000250	563..677		12/59 (20%)
		RhoGAP_OCRL1	667..895	CDD:239845
		Clathrin box 2	701..705
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836217
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740