DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9784 and Inpp5k

DIOPT Version :9

Sequence 1:	NP_001259623.1	Gene:	CG9784 / 32629	FlyBaseID:	FBgn0030761	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_006532570.1	Gene:	Inpp5k / 19062	MGIID:	1194899	Length:	472	Species:	Mus musculus

Alignment Length:	504	Identity:	155/504 - (30%)
Similarity:	234/504 - (46%)	Gaps:	94/504 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VYVVTWNVGSRFPDNISLRHLLGL--QDVTVDKDTKETNAHLPDIYALGLQEVNAQPQQQVLGLF 95
            |:||||||.|..| .:.|..||.|  ||:.:            |||.:||||:|.    .::.|.
Mouse    34 VHVVTWNVASAAP-TVDLSDLLQLNNQDLNL------------DIYIIGLQEMNF----GIISLL 81

  Fly    96 K----EDPWTHKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIEAEFTRTGFGGIWGN 156
            .    ||||:....::|...::|.:...:||||||.:|.:.||:.::|.|..:.|.||..|.|||
Mouse    82 SDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGN 146

  Fly   157 KGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYREIYDHDYVFWFGDL 221
            ||.|:|...|||..::.:..||..|.:..|:|:|.:.:|||:..:.......|.|||.:.||||:
Mouse   147 KGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDM 211

  Fly   222 NFRLQGSDSSTEVRELVRDESQHEALIQRDQLYQVREKSQLAFQVLQERLPAFPPTFKFREGTSE 286
            |||::..........:.|  ..::.|.::|||:..::..|| .:..||....||||:||...::.
Mouse   212 NFRIEDFGLLFVQESITR--KYYKELWEKDQLFIAKKNDQL-LREFQEGPLLFPPTYKFDRHSNN 273

  Fly   287 YDL---KRRPAWTDRIMYAVQPLNRQPGMQLSIEQC-----------SYKSHPLYTISDHKPVTS 337
            ||.   ||:|||||||::.   |.|||.....:...           :|.||..|:||||||||.
Mouse   274 YDTSEKKRKPAWTDRILWR---LKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTG 335

  Fly   338 DFTIKLYPNVRAPGVVFSPLSLWKIGDENTVEYHKQAEFDEGSNDWIGIF----PSEYASLADYV 398
            .|.::|.|.:..|.:...|..||.:.::..:.|....||...|.||||::    ......:.|||
Mouse   336 TFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVIQQVGMRHINDYV 400

  Fly   399 AYEYVNQAESPSSSDSNHQPDPFETPSHHRRGRHHHRNRQRQRRHQEANAQELVRLDFADDVELR 463
            ||.:|...:....::.|                                 |..:.:....|.|
Mouse   401 AYVWVGDNQVSYGNNPN---------------------------------QVYINISAIPDTE-- 430

  Fly   464 HGEQYLLIYFRSTGVRGVTSLAGVSGVFVAEKRHGSPHRTEYHVDXLAE 512
              :|:||.|:.:    .:.|:.|:|..|..      |.|:....| |.|
Mouse   431 --DQFLLCYYSN----NLHSVVGISQPFKI------PIRSFLREDTLYE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9784	NP_001259623.1	INPP5c_INPP5J-like	31..341	CDD:197328	118/327 (36%)
Inpp5k	XP_006532570.1	EEP	32..339	CDD:382041	118/327 (36%)
Inpp5k	XP_006532570.1	SKICH	350..454	CDD:375315	29/144 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836199
Domainoid	1	1.000	207	1.000	Domainoid score	I2871
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3490
Isobase	1	0.950	-	0	Normalized mean entropy	S4193
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336369at33208
OrthoFinder	1	1.000	-	-		FOG0001973
OrthoInspector	1	1.000	-	-		mtm8773
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1469
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.810