Protein Alignment SMC3 and SMC5

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_014608.1
• Gene: SMC5 / 854123
• SGDID: S000005394
• Length: 1093
• Species: Saccharomyces cerevisiae
• Alignment Length: 1264
• Identity: 247/1264 - (19%)
• Similarity: 490/1264 - (38%)
• Gaps: 321/1264 - (25%)

  Fly     3 IKQIIIQGFKSYKDQTVVE-PFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLL 65
            |.:|.:|.|.:|   |:.| ......|:::|.||||||.|..|:...|:.:..:: |.::.:..:
Yeast    42 IIKIRLQDFVTY---TLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFI 103

  Fly    66 HEGTGARVISAYVEIIFDNSDNRVPID-----KEEIFLRRVI--GAKKDQYFLNKKVVPRNEVVN 123
            ..|...    :.:||...||.|...|:     .|.|.:.|:|  ..::..|.:|...|..:.|..
Yeast   104 KNGQDV----SKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESVVKT 164

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            |:........|....:.|.::.:.|      |||.::.:..|             :|..|:.:..
Yeast   165 LVAQLNIQLDNLCQFLSQERVEEFA------RLKSVKLLVET-------------IRSIDASLLD 210

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKE-----YQKWDKTRRTLEYIRYETELKDTKKALDELQLQR-- 246
            :.:.|:.::...|:|:::.:..|.     .|:.||.|:::|      .|:|.:....|::|..
Yeast   211 VLDELRELQGNEQSLQKDLDFKKAKIVHLRQESDKLRKSVE------SLRDFQNKKGEIELHSQL 269

  Fly   247 ------KSSSDKKKIYNIEIQKAQEKIKDVQKNLK---EAKKKVQSTKEERSVLMTEQ-----QQ 297
                  |...:|..||..|.::|:..::.:.|:.|   ..||.:::..||    :||:     .:
Yeast   270 LPYVKVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEE----LTEKCSLKTDE 330

  Fly   298 LLREKTKLDLTIVDLN---DEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEE 359
            .|:.|.|::.....||   |||.......|......|.|:.||         :..|.:.::.:|.
Yeast   331 FLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATI---------ISTKEDFLRSQEI 386

  Fly   360 DCSRELQLK------EQKRKELYAKQGRGSQFSSRED-RDKWITNELKSISKQTRDKIAHHAKLV 417
            .....|..|      :.||||:..|:|......|..| :...|.:|::||.:|...|
Yeast   387 LAQTHLPEKSVFEDIDIKRKEIINKEGEIRDLISEIDAKANAINHEMRSIQRQAESK-------- 443

  Fly   418 EDLKKDATSEKDLGQKIEEHSSELEQLR---LQIDEHNKKYYELKKTKDQHQSMRNELWRKETQM 479
               .|..|:...:|  |.....:|:::|   |.:.|              |..|::::
Yeast   444 ---TKSLTTTDKIG--ILNQDQDLKEVRDAVLMVRE--------------HPEMKDKI------- 482

  Fly   480 TQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCD 544
               |:.....:|..:....:...:.:.........|:||         :..:.:..|:::.|..:
Yeast   483 ---LEPPIMTVSAINAQFAAYLAQCVDYNTSKALTVVDS---------DSYKLFANPILDKFKVN 535

  Fly   545 KTIYTAVEVTAANRLFHHIVESE------YEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPD 603
            ....::.:.|..       |.:|      :||  .|.:.    :.|:...|.:.....|||..|.
Yeast   536 LRELSSADTTPP-------VPAETVRDLGFEG--YLSDF----ITGDKRVMKMLCQTSKIHTIPV 587

  Fly   604 DPDSI--PMISKLKYDEQHDKAL--RYIFGKTLICRNLERATELAKSTGLDCVTLDGDQVSSKGS 664
            ....:  ..|.||.....:.|.|  |.|.|..|:
Yeast   588 SRRELTPAQIKKLITPRPNGKILFKRIIHGNRLV------------------------------- 621

  Fly   665 LTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSK 729
                           ..|::.|.|      |::......:|.|.....||:|..||.
Yeast   622 ---------------DIKQSAYGS------KQVFPTDVSIKQTNFYQGSIMSNEQKI-------- 657

  Fly   730 DVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQ 794
                :::.||..:|.|.         .:|     |::|:::::.||....||     |.|:|::
Yeast   658 ----RIENEIINLKNEY---------NDR-----KSTLDALSNQKSGYRHEL-----SELASKN- 698

  Fly   795 REIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNL---LINNLFRRRDELIQALQEISVEDR- 855
               |.:|.:..:||:..|:...::...|..:.|||.|   ...::.::..::...:|::.::.|
Yeast   699 ---DDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRH 760

  Fly   856 --------KRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAE 912
                    .:.|.||:.||:|.:    .:..:.:.::..:.:.:....|.:.:|::....:|:..
Yeast   761 LLSKMASSMKSLKNCQKELISTQ----ILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFV 821

  Fly   913 ENLNKDSKQLEKWSTK----ENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQ 973
            :.: :|:.:.:.|..:    :....||:::..||....|          ..:|..:...|:|...
Yeast   822 KEM-RDTPEFQSWMREIRSYDQDTKEKLNKVAEKYEEEG----------NFNLSFVQDVLDKLES 875

  Fly   974 HLKKYNHVNKKA--LDQFLS-FSEQKEKLYRRKEELDIGDQKI---HMLIQSLEMQKVEAIQFTF 1032
            .:...||.....  |||..: ..|.:..:.::.::|:....|:   |.:::    .|::.|   .
Yeast   876 EIAMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLE----PKLDDI---V 933

  Fly  1033 RQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQ 1097
            .:::..|.::|..:...||..|     :...|..|.::|         |.|.|.. .|.:::::.
Yeast   934 SKISARFARLFNNVGSAGAVRL-----EKPKDYAEWKIE---------IMVKFRD-NAPLKKLDS 983

  Fly  1098 --LSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDA-----MHRKAVANMIHELSDTAQFIT 1155
              .|||::::..:..:.::|:...|||.:.|||:|.:|:     :|:..|.|...|  :|:|:..
Yeast   984 HTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAE--NTSQYFL 1046

  Fly  1156 TTFRPELLENAHKFYGVRFRNKVSHIDCV 1184
            .|  |:||...|  |..:.|     |.||
Yeast  1047 IT--PKLLTGLH--YHEKMR-----IHCV 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	244/1258 (19%)
		ABC_SMC3_euk	3..>159	CDD:213239	41/164 (25%)
		SMC_hinge	533..643	CDD:214944	23/119 (19%)
		TMPIT	678..>760	CDD:285135	16/81 (20%)
		CHD5	<780..>822	CDD:282299	10/41 (24%)
		P-loop_NTPase	<1088..1182	CDD:304359	26/100 (26%)
SMC5	NP_014608.1	Smc	42..1069	CDD:224117	247/1264 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810