DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and SMC3

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_012461.1	Gene:	SMC3 / 853371	SGDID:	S000003610	Length:	1230	Species:	Saccharomyces cerevisiae

Alignment Length:	1280	Identity:	388/1280 - (30%)
Similarity:	695/1280 - (54%)	Gaps:	132/1280 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |:||::||:|||:|:::|:::.|....||::|.|||||||||.||:|||||::::|:.|:||.|:
Yeast     1 MYIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAAIRFVLSDDYSNLKREERQGLI 65

  Fly    66 HEGTGARVISAYVEIIFDNSDNRVPIDK-------EEIFLRRVIGAKKDQYFLNKKVVPRNEVVN 123
            |:|:|..|:||.|||:|.:.|:.:.:..       :|:.:||.:|.|||.|.||.:.|.:.::|.
Yeast    66 HQGSGGSVMSASVEIVFHDPDHSMILPSGVLSRGDDEVTIRRTVGLKKDDYQLNDRNVTKGDIVR 130

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            :||:||||.:|||.||.||||..:..|.|..||:||.:|.|.:.::.:.:.||..:.||:.|..:
Yeast   131 MLETAGFSMNNPYNIVPQGKIVALTNAKDKERLQLLEDVVGAKSFEVKLKASLKKMEETEQKKIQ 195

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKK 253
            |::.:..:..:|..:|:|::||::|.:.::.|:..::..|:.||.:....::.|.....::....
Yeast   196 INKEMGELNSKLSEMEQERKELEKYNELERNRKIYQFTLYDRELNEVINQMERLDGDYNNTVYSS 260

  Fly   254 KIYNIEIQKAQEKIKDVQKNLK--EAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEV 316
            :.|..|:.|.::.|..|.|.|.  ||..|:::..:.:...:.| .::.::.|.:::.|.|:..::
Yeast   261 EQYIQELDKREDMIDQVSKKLSSIEASLKIKNATDLQQAKLRE-SEISQKLTNVNVKIKDVQQQI 324

  Fly   317 QGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGR 381
            :.:.:.:......||.:|..|.:|:::|..:.|:|:.:.::|.....:|...:||:::|..|:|.
Yeast   325 ESNEEQRNLDSATLKEIKSIIEQRKQKLSKILPRYQELTKEEAMYKLQLASLQQKQRDLILKKGE 389

  Fly   382 GSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQL-- 444
            .::|.|:::||.||.:|::.:    :..|.:..:|...|:.|.||.:.....|:|   |:|:|
Yeast   390 YARFKSKDERDTWIHSEIEEL----KSSIQNLNELESQLQMDRTSLRKQYSAIDE---EIEELID 447

  Fly   445 -------RLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAG 502
                   :.|:::.:.:...||:...:....|.||||||.::...|:|...::::..:.:.....
Yeast   448 SINGPDTKGQLEDFDSELIHLKQKLSESLDTRKELWRKEQKLQTVLETLLSDVNQNQRNVNETMS 512

  Fly   503 KPILNGCDSVRKVLDSFVERGGQSAEIA-RAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVES 566
            :.:.||..:|:::.:..        :|: .:.:|.:.|....:....|..||...|.|||.:|::
Yeast   513 RSLANGIINVKEITEKL--------KISPESVFGTLGELIKVNDKYKTCAEVIGGNSLFHIVVDT 569

  Fly   567 EYEGTQILKEMNKLKLPGEVTFMPLNRL----QVKIHDYPDDPDS----IPMISKLKYDEQHDKA 623
            |...|.|:.|:.::| .|.|||:|||||    .||   :|.:..:    .|:|.|:||:.:.:||
Yeast   570 EETATLIMNELYRMK-GGRVTFIPLNRLSLDSDVK---FPSNTTTQIQFTPLIKKIKYEPRFEKA 630

  Fly   624 LRYIFGKTLICRNLERATELAKSTGLDCVTLDGDQVSSKGSLTGGYFNT-SRSRLEMQKKRTEYT 687
            ::::||||::.::|.:..:|||...|:.:|||||:...:|.|||||.:. .|:|||..|...|..
Yeast   631 VKHVFGKTIVVKDLGQGLKLAKKHKLNAITLDGDRADKRGVLTGGYLDQHKRTRLESLKNLNESR 695

  Fly   688 SQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQY 752
            ||..:..::|..:||||...:..|:.:...::|....:       |.|...|.:.:..|...:..
Yeast   696 SQHKKILEELDFVRNELNDIDTKIDQVNGNIRKVSNDR-------ESVLTNIEVYRTSLNTKKNE 753

  Fly   753 RAPKERSLAQCKASLESMTSTK-------SSLEAELKQELMSTLSSQDQREIDQLNDDI----RR 806
            :...|.||......||.:.:.:       ::.|.:|.||..|.||.:::..::.|..:|    .:
Yeast   754 KLILEESLNAIILKLEKLNTNRTFAQEKLNTFENDLLQEFDSELSKEEKERLESLTKEISAAHNK 818

  Fly   807 LN--QENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSA 869
            ||  .:..|..|..:      :.|:..|.:.|..:.::|...:.|:.           ...:...
Yeast   819 LNITSDALEGITTTI------DSLNAELESKLIPQENDLESKMSEVG-----------DAFIFGL 866

  Fly   870 EKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNE 934
            :..:|::..:.|.:||:...||.....:|:|:|:.:     |||..||  |.|||.:.::.:|.:
Yeast   867 QDELKELQLEKESVEKQHENAVLELGTVQREIESLI-----AEETNNK--KLLEKANNQQRLLLK 924

  Fly   935 KID---------------------ECTEKIASLGAVP---LVDPSYTRMSLKNIFKELEKANQHL 975
            |:|                     |..::|..:|.:|   ||: .::.::...:.:.|...|..:
Yeast   925 KLDNFQKSVEKTMIKKTTLVTRREELQQRIREIGLLPEDALVN-DFSDITSDQLLQRLNDMNTEI 988

  Fly   976 KKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFT 1040
            ....:|||:|.:.|..|:|:::.|..|..|||.....|..||..|:.|||.|:..||::|::||.
Yeast   989 SGLKNVNKRAFENFKKFNERRKDLAERASELDESKDSIQDLIVKLKQQKVNAVDSTFQKVSENFE 1053

  Fly  1041 KVFKKLVPMGAGFLILKTK-DNEGD-----EMEKEVENSDA---------FTGIGIRVSFTGVEA 1090
            .||::|||.|...||:..| ||..|     :::.:.|::::         :||:.|.|||...:.
Yeast  1054 AVFERLVPRGTAKLIIHRKNDNANDHDESIDVDMDAESNESQNGKDSEIMYTGVSISVSFNSKQN 1118

  Fly  1091 EMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFIT 1155
            |...:.|||||||::.|:|||.:||..|||.||||||||.|||..:|.|||.::.|||..||||.
Yeast  1119 EQLHVEQLSGGQKTVCAIALILAIQMVDPASFYLFDEIDAALDKQYRTAVATLLKELSKNAQFIC 1183

  Fly  1156 TTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVEDDSTHA 1200
            ||||.::|:.|.||:.|::.||:|.:..|.||||..|:...:..|
Yeast  1184 TTFRTDMLQVADKFFRVKYENKISTVIEVNREEAIGFIRGSNKFA 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	379/1257 (30%)
		ABC_SMC3_euk	3..>159	CDD:213239	76/162 (47%)
		SMC_hinge	533..643	CDD:214944	39/117 (33%)
		TMPIT	678..>760	CDD:285135	17/81 (21%)
		CHD5	<780..>822	CDD:282299	12/47 (26%)
		P-loop_NTPase	<1088..1182	CDD:304359	51/93 (55%)
SMC3	NP_012461.1	Smc	1..1221	CDD:224117	388/1280 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346463
Domainoid	1	1.000	599	1.000	Domainoid score	I25
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3974
Inparanoid	1	1.050	612	1.000	Inparanoid score	I125
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54174
OrthoFinder	1	1.000	-	-		FOG0003940
OrthoInspector	1	1.000	-	-		oto99558
orthoMCL	1	0.900	-	-		OOG6_101525
Panther	1	1.100	-	-	LDO	PTHR43977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1353
SonicParanoid	1	1.000	-	-		X3237
TreeFam	1	0.960	-	-
	15	14.790