DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and SMC2

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_116687.1 Gene:SMC2 / 850589 SGDID:S000001927 Length:1170 Species:Saccharomyces cerevisiae


Alignment Length:1276 Identity:330/1276 - (25%)
Similarity:585/1276 - (45%) Gaps:208/1276 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            |.::::||.|||||..:||:..:|.:.|.:.|.|||||||...||.|||. ...:.:|....|.|
Yeast     1 MKVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSD-NRVPI---DKEEIFL-RRVIGAKKDQYFLNKKVVPRNEVVNL 124
            :::...|.|..|.|.|:|||:| :..||   :..:|.: |:|:.....:|.:|....|:..|:.|
Yeast    66 IYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQISVTRQVVLGGTSKYLINGHRAPQQSVLQL 130

  Fly   125 LESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKI 189
            .:|...:.:||.:::.||||.::.....|..|.|:.|.|||:::::|:|::...:.:.::|:::.
Yeast   131 FQSVQLNINNPNFLIMQGKITKVLNMKPSEILSLIEEAAGTKMFEDRREKAERTMSKKETKLQEN 195

  Fly   190 SEYL-KTIEDRLQTLEEEKEELKEYQK----WDKTRR-TLEYIRYETELKDTKKALDELQLQRKS 248
            ...| :.||.:|:.|..||....|:|.    .:||.| .:.|..|..:.|.|     .::...::
Yeast   196 RTLLTEEIEPKLEKLRNEKRMFLEFQSTQTDLEKTERIVVSYEYYNIKHKHT-----SIRETLEN 255

  Fly   249 SSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEER-----SVLMTEQQQLLRE----KTK 304
            ...:.|:.|..::|..|:|..:.::::|.  |:|..||..     |.|..::..||.|    ||.
Yeast   256 GETRMKMLNEFVKKTSEEIDSLNEDVEEI--KLQKEKELHKEGTISKLENKENGLLNEISRLKTS 318

  Fly   305 LDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKE 369
            |.:.:.:|||..:   ||| ..:.|:.:....:.|::....:.:..|   |..:|..|::..|.:
Yeast   319 LSIKVENLNDTTE---KSK-ALESEIASSSAKLIEKKSAYANTEKDY---KMVQEQLSKQRDLYK 376

  Fly   370 QKRKELYAKQGRGSQFSSRED--------RDKWITNELKSISKQTRDKIAHHAK---LVEDLKKD 423
            :| :||.:....|...:...|        :.|...||:....|::..|:....|   .:|...|:
Yeast   377 RK-EELVSTLTTGISSTGAADGGYNAQLAKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKE 440

  Fly   424 ATSEKDLGQK-IEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHK 487
            ||.:.:|..| :::.....::||.::.|:.   ::..:.||..|       |::...:...||.|
Yeast   441 ATKDNELNVKHVKQCQETCDKLRARLVEYG---FDPSRIKDLKQ-------REDKLKSHYYQTCK 495

  Fly   488 --EELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDK---TI 547
              |.|.|....|.....||..|       ...|||             :|.|.:.|..|.   ..
Yeast   496 NSEYLKRRVTNLEFNYTKPYPN-------FEASFV-------------HGVVGQLFQIDNDNIRY 540

  Fly   548 YTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMIS 612
            .||::..|..|||:.:|:.....||:|:   :.:|...||.:||:    ||:..|.....:.:..
Yeast   541 ATALQTCAGGRLFNVVVQDSQTATQLLE---RGRLRKRVTIIPLD----KIYTRPISSQVLDLAK 598

  Fly   613 K------------LKYDEQHDKALRYIFGKTLICRNLERATEL-------AKSTGLDCVTLDGDQ 658
            |            :::||...||:.:|||.:|||.:.|.|.::       |:|     :||.||.
Yeast   599 KIAPGKVELAINLIRFDESITKAMEFIFGNSLICEDPETAKKITFHPKIRARS-----ITLQGDV 658

  Fly   659 VSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELK---STENNINSIVSEMQK 720
            ...:|:|:||..|||.|.|...:|..:...||...:..|:.:..||:   :|.....:|.|::..
Yeast   659 YDPEGTLSGGSRNTSESLLVDIQKYNQIQKQIETIQADLNHVTEELQTQYATSQKTKTIQSDLNL 723

  Fly   721 TETKQGKSK-DVFEKVQGEIRLMKEELVR----IEQYRAPKERSLAQCKASLESM-------TST 773
            :..|...:| ::......:|....||::|    .|.....|:.||.:|:..:.::       .|.
Yeast   724 SLHKLDLAKRNLDANPSSQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYDSD 788

  Fly   774 KSSLEAELKQEL------MSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLL 832
            |.|...|||:||      :....|:.:|:.|..         :|.|..|:::..|:..||  .||
Yeast   789 KGSKLNELKKELKLLAKELEEQESESERKYDLF---------QNLELETEQLSSELDSNK--TLL 842

  Fly   833 INNLFRRRDELIQALQEISVE--DRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQK 895
            .|:|        ::::.:.:|  |.:.|:...:.:||:       |.::|.|.:||:|:   :..
Yeast   843 HNHL--------KSIESLKLENSDLEGKIRGVEDDLVT-------VQTELNEEKKRLMD---IDD 889

  Fly   896 ELQQELETHVRK----EKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSY 956
            || .||||.::|    :|.:|..|.|....|.|:.:..|.:.:.|::..:|...|....||    
Yeast   890 EL-NELETLIKKKQDEKKSSELELQKLVHDLNKYKSNTNNMEKIIEDLRQKHEFLEDFDLV---- 949

  Fly   957 TRMSLKNIFKE---------LEKANQHLKKYNHVNKKALDQFLSFSEQKEK----LYRRKEELDI 1008
                 :||.|:         .|::.|..:|:..:.||.....::..|..||    |....:.::.
Yeast   950 -----RNIVKQNEGIDLDTYRERSKQLNEKFQELRKKVNPNIMNMIENVEKKEAALKTMIKTIEK 1009

  Fly  1009 GDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENS 1073
            ...||...|..|...|.|.:..|:.:|..:|..:|..|:|.....|:             ..|..
Yeast  1010 DKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFAKLV-------------PCEGK 1061

  Fly  1074 DAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRK 1138
            |...|:.::|....:..|  .:.:|||||:||:||:||.::.:..|||.|:.||:|.|||..|.:
Yeast  1062 DVTQGLEVKVKLGNIWKE--SLIELSGGQRSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQ 1124

  Fly  1139 AVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVS 1179
            .:.::|......:|||..:.:..:..||::.:..||::..|
Yeast  1125 NIGHLIKTRFKGSQFIVVSLKEGMFANANRVFRTRFQDGTS 1165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 329/1275 (26%)
ABC_SMC3_euk 3..>159 CDD:213239 55/161 (34%)
SMC_hinge 533..643 CDD:214944 35/124 (28%)
TMPIT 678..>760 CDD:285135 17/89 (19%)
CHD5 <780..>822 CDD:282299 11/47 (23%)
P-loop_NTPase <1088..1182 CDD:304359 32/92 (35%)
SMC2NP_116687.1 Smc 1..1169 CDD:224117 330/1276 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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