DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and SMC1A

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_006297.2	Gene:	SMC1A / 8243	HGNCID:	11111	Length:	1233	Species:	Homo sapiens

Alignment Length:	1317	Identity:	314/1317 - (23%)
Similarity:	584/1317 - (44%)	Gaps:	264/1317 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            :|.|.|:.|||||.:.::.|| :|...::|.|||||||...||.|||.::.::||.:..:.|:|
Human     4 LKLIEIENFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIH- 66

  Fly    68 GTGARV-----ISAYVEIIF--DNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLL 125
              ||.|     ..|:|.:::  :.:::|.       |.|.::|. ..:|.:|.|||..:|....|
Human    67 --GAPVGKPAANRAFVSMVYSEEGAEDRT-------FARVIVGG-SSEYKINNKVVQLHEYSEEL 121

  Fly   126 ESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT----RVYDERKEESLNLLRETDSKV 186
            |..|.......::|.||.:..:|......|..|..|::.:    :.||:||:|.:....:|....
Human   122 EKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNY 186

  Fly   187 EKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQR--KSS 249
            .:    .|.|....:..::||||...||     |...|.:|.:.:|:..|...:|:::::  |..
Human   187 HR----KKNIAAERKEAKQEKEEADRYQ-----RLKDEVVRAQVQLQLFKLYHNEVEIEKLNKEL 242

  Fly   250 SDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLND 314
            :.|.|    ||:|.::::..|:..|||.||       |...:|.||||:.:|..:.|   .:||.
Human   243 ASKNK----EIEKDKKRMDKVEDELKEKKK-------ELGKMMREQQQIEKEIKEKD---SELNQ 293

  Fly   315 EVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQ 379
            :.....|:||....::|.|:..    :|.|.:.:..|:..|...::..:|:...|:.|:|...:.
Human   294 KRPQYIKAKENTSHKIKKLEAA----KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM 354

  Fly   380 GRGSQFSSREDRDKWIT---NELKSISKQTRDKIAHHAKLVEDLKK---DATSEKDL-----GQK 433
            ...||...|:     :|   |::|...:...:.....|.|.::|:|   |..:::|.     .:|
Human   355 EEESQSQGRD-----LTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKK 414

  Fly   434 IEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALR 498
            :|..:...::|| :|:|:.|:..:|::.....:....|..:.|.::|::::..|..:...::.|.
Human   415 VETEAKIKQKLR-EIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELN 478

  Fly   499 SMAGKPILNGCDSVRKVLDSFVERGGQSAE---------IARAY----YGPVIENFSC---DKTI 547
            .:           :.::.|:.::|...|.:         |.|.|    ||.:|:  .|   .|..
Human   479 QV-----------MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLID--LCQPTQKKY 530

  Fly   548 YTAVEVTAANRLFHHIVESEYEG---TQILKEMNKLKLPGE-VTFMPLNRLQVKIHDYPDD---- 604
            ..||.......:...||:||..|   .|.:||..     || .||:||:.|:||    |.|
Human   531 QIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQR-----GEPETFLPLDYLEVK----PTDEKLR 586

  Fly   605 --PDSIPMISKLKYDEQH-DKALRYIFGKTLICRNLERATELA-------KSTGLDCVTLDGDQV 659
              ..:..:|..::|:..| .|||:|..|..|:|.|:|.|..:|       |:     |.|||...
Human   587 ELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKT-----VALDGTLF 646

  Fly   660 SSKGSLTGGYFN-TSRSRL-------EMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSI-- 714
            ...|.::||..: .:::|.       ::::|:...|.::.| :.|..:...||:..::..:.:
Human   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKE-QMKAKRKEAELRQVQSQAHGLQM 710

  Fly   715 -----VSEMQKTETK------QGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLE 768
                 .|::::|:|:      |.||     |::.|:......:..|::....:||.:...|..:
Human   711 RLKYSQSDLEQTKTRHLALNLQEKS-----KLESELANFGPRINDIKRIIQSREREMKDLKEKM- 769

  Fly   769 SMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLL- 832
                  :.:|.|:.:|....:..::.||.::  :.::|.|:..|    :|::||.:|.:|...|
Human   770 ------NQVEDEVFEEFCREIGVRNIREFEE--EKVKRQNEIAK----KRLEFENQKTRLGIQLD 822

  Fly   833 --INNLFRRRDEL-------------IQALQEIS------VEDRKRKLNNCKTELVSAEKRIKKV 876
              .|.|...:|::             |:.|::..      :::...:|.:.|.:.::.:..:...
Human   823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDK 887

  Fly   877 NSDLEEIEKRV----MEAVQLQKELQQELETHVRKEKEAEENLNK-----------------DSK 920
            |.::|||.|::    .|...||||: ..:||.:.:::....||.:                 |..
Human   888 NHEMEEIRKKLGGANKEMTHLQKEV-TAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS 951

  Fly   921 QLEKWSTKENMLNEKIDECTEKIASLGA-VPLVDPSYTRM--SLKN------IFKELEKANQHLK 976
            |.|..|..|:.::.     :::|:|:.| ..|::..|..:  .||:      |.:|:....|.|.
Human   952 QEEGSSQGEDSVSG-----SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLN 1011

  Fly   977 KYNHV-------NKKAL-------DQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEA 1027
            :...|       |.||:       |:|...|::.|...:|.       :|.....:.::.::.:.
Human  1012 EQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRA-------KKAKQAFEQIKKERFDR 1069

  Fly  1028 IQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEM 1092
            ....|..||.|..:::|.|....:....|..::.|...::            ||..:........
Human  1070 FNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLD------------GINYNCVAPGKRF 1122

  Fly  1093 REMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQF--IT 1155
            |.|:.||||:|::.||||:|:|....||||::.||||.|||..:...|||.|.|.| |..|  |.
Human  1123 RPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQS-TCNFQAIV 1186

  Fly  1156 TTFRPELLENAHKFYGV 1172
            .:.:.|....|....||
Human  1187 ISLKEEFYTKAESLIGV 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	314/1317 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	51/162 (31%)
		SMC_hinge	533..643	CDD:214944	40/127 (31%)
		TMPIT	678..>760	CDD:285135	17/94 (18%)
		CHD5	<780..>822	CDD:282299	8/41 (20%)
		P-loop_NTPase	<1088..1182	CDD:304359	37/87 (43%)
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:308206	314/1317 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..308		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..369		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..966		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810