DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and SMC6

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	XP_011531409.1	Gene:	SMC6 / 79677	HGNCID:	20466	Length:	1110	Species:	Homo sapiens

Alignment Length:	1244	Identity:	243/1244 - (19%)
Similarity:	468/1244 - (37%)	Gaps:	338/1244 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KSYKDQTVVEPFDKRHNV--VVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLLHEGTGARV 73
            |::...:::.||....||  |||.||||||....|:...|....... |....:..:.:|..:..
Human    54 KNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSAD 118

  Fly    74 IS---------AYVEIIFDNS---DNRVPIDKEEIFLRR-----VIGAKKDQYFLNKKVVPRNEV 121
            ||         |:...::.||   ...:.||....:..:     |:..:|:            |:
Human   119 ISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKE------------EL 171

  Fly   122 VNLLESAGFSSSNPYYIVKQGKINQMATA---ADSYRLKLLREVAGTRVYDERKEESLNLLRETD 183
            :.:|:.......||..::.|....|...:   .|.|:..:    ..|::  |:.:|..:.:.||.
Human   172 IAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFM----KATQL--EQMKEDYSYIMETK 230

  Fly   184 SKVEKISEYLKTIEDRLQTLEE---EKEELKEYQKWDKTRRT-LEYIRYE---TELKDTKKALDE 241
               |:..|.:...|:||..|:.   ||||..:......|.:| ||.:::|   ..:.:.:|.|:.
Human   231 ---ERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNA 292

  Fly   242 LQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLD 306
            ::...|...|:....:.::::.|.::.:.::..|:.:.|::...||.:....|...|
Human   293 IRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMAL-------- 349

  Fly   307 LTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEED-CSRELQLKEQ 370
                      :.|..:|:||..|.:.|      ..:.|::    |:|:|:.:|. |.|..:||:.
Human   350 ----------KADVVAKKRAYNEAEVL------YNRSLNE----YKALKKDDEQLCKRIEELKKS 394

  Fly   371 KRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIE 435
            ..:.|..::      ..|:.:..|:...:|:...|                     |..:.|:||
Human   395 TDQSLEPER------LERQKKISWLKERVKAFQNQ---------------------ENSVNQEIE 432

  Fly   436 EHSSELEQLRLQIDEHNKKYYELKKTKDQHQSM-RNELWRKETQMTQQLQTHKEELSRADQALRS 499
            :....:|                 |.|::|..: |.||..|......|.|..:.:.|:.|:..|.
Human   433 QFQQAIE-----------------KDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480

  Fly   500 MAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSC----DKTIYTAVEVTAANRLF 560
            ....|.|      .:.:|....:|       ...|.||....:|    |..:..|:|......|.
Human   481 GPNVPAL------LEAIDDAYRQG-------HFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532

  Fly   561 HHIVESEYEGTQILKEMNKLKLPGEVTFMP---LNRLQVKIHD-------YPDDPDSIPMISKLK 615
            .:...:..:...:...|.:..|||  |..|   ::..:.:|:|       :||.|   .:::.|:
Human   533 AYCCHNHADERVLQALMKRFYLPG--TSRPPIIVSEFRNEIYDVRHRAAYHPDFP---TVLTALE 592

  Fly   616 YDEQHDKALRYIFGKTLI-CRNLE-----------RATELAKSTGLDC---VTLDGDQVSSKGSL 665
            .|..       :...:|| .|.:|           ||...::....:|   .|.|||||     .
Human   593 IDNA-------VVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQV-----F 645

  Fly   666 TGGYFNTSRSR------------LEMQKKRTEYTSQIAEFEKKLSKLRNELKSTEN--------- 709
            .|.|:::..:|            .:::.:....|:||...::.||.|..::|..|.
Human   646 AGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHY 710

  Fly   710 -----NINSIVSEMQKTET-KQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLE 768
                 .|...:||:::.|. ::.:|.|: ..::.|.:..|.::..:|::       :.|.|.::|
Human   711 KELKMKIRKNISEIRELENIEEHQSVDI-ATLEDEAQENKSKMKMVEEH-------MEQQKENME 767

  Fly   769 SMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQE-NKEAFTQRMQFEVRKNKLDNLL 832
            .:.|.|  :|||.|.:.:....:|.....|.|.|::...:.| :.:...:|...|.:|..||.|
Human   768 HLKSLK--IEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTL- 829

  Fly   833 INNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRV----MEAVQL 893
                                ..:||:|:..:.||.....:.:::..:..|:||..    .|..:|
Human   830 --------------------NKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRL 874

  Fly   894 QKELQQELETH------VRKEKEAEEN-LNKDSK--QLEKWSTKENMLNEKIDECTEKIASLGAV 949
            ::::|.|..:|      :|:.:||.|. |:.|||  .|:|:                 |..||
Human   875 RQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKF-----------------IKLLG-- 920

  Fly   950 PLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIH 1014
                         .|.:...|..|..:.:...||..|..:::..:.:....|.|...|      :
Human   921 -------------EIMEHRFKTYQQFRSFRQKNKPNLYYYINLFQMQCLTLRCKLYFD------N 966

  Fly  1015 MLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGI 1079
            :|.|.....|:            ||                    |::.:.:...|:..:
Human   967 LLSQRAYCGKM------------NF--------------------DHKNETLSISVQPGE----- 994

  Fly  1080 GIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMI 1144
                   |.:|...:|..||||::|...:..|.|:.....:||...||.|..:|.::|:...::|
Human   995 -------GNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLI 1052

  Fly  1145 HELSDTAQF 1153
            .:::|:.:|
Human  1053 LKMADSQRF 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	243/1244 (20%)
		ABC_SMC3_euk	3..>159	CDD:213239	35/169 (21%)
		SMC_hinge	533..643	CDD:214944	27/135 (20%)
		TMPIT	678..>760	CDD:285135	17/96 (18%)
		CHD5	<780..>822	CDD:282299	8/42 (19%)
		P-loop_NTPase	<1088..1182	CDD:304359	19/66 (29%)
SMC6	XP_011531409.1	Smc	48..1088	CDD:224117	243/1244 (20%)
		ABC_SMC6_euk	48..>204	CDD:213243	33/161 (20%)
		Fib_alpha	<662..742	CDD:285864	14/80 (18%)
		DUF5098	701..>835	CDD:293628	30/164 (18%)
		ABC_SMC6_euk	<996..1094	CDD:213243	19/66 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900