DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and Smc4

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_598547.1 Gene:Smc4 / 70099 MGIID:1917349 Length:1286 Species:Mus musculus


Alignment Length:1292 Identity:308/1292 - (23%)
Similarity:566/1292 - (43%) Gaps:232/1292 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |..|:.|.||||..:.|:.||.||.:.::|.|||||||...::.||.......:|.::...|:|.
Mouse    82 ITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHN 146

  Fly    68 GTGARVI-SAYVEIIFDNSDNRVPIDKE----------EIFLRRVIGAKKDQ---YFLNKKVVPR 118
            ....:.| |..||:.|...     ||||          ..::.|.  |.:|.   |.::.|....
Mouse   147 SDEHKDIQSCTVEVHFQKI-----IDKEGDDYEVLPNSNFYVSRT--AYRDSTSVYHISGKKKTF 204

  Fly   119 NEVVNLLESAGFSSSNPYYIVKQGKINQMA-------TAADSYRLKLLREVAGTRVYDE------ 170
            .:|.|||.|.|....:..:::.||::.|:|       |..|...|:.|.::.|....:|      
Mouse   205 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLC 269

  Fly   171 RKEESLNLLRETDSKVEKISEYLKTIEDRLQTLEEEKEELKEY-----QKWDKTRRTLEYIRYE- 229
            |:.|.||     :.:.||::. :|.:|.....||.||....|:     :.:.|.....:|..|: 
Mouse   270 RRVEILN-----EHRGEKLNR-VKMVEKEKDALEGEKNIAIEFLTLENEMFKKKNHICQYYIYDL 328

  Fly   230 ----TELKDTKKALDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSV 290
                .|:...|:.:.|   ..|..::|..:.:.|::.....:|||:|.|.:..|.::..||:.:.
Mouse   329 QNRIAEITTQKEKIHE---DTKEITEKSNVLSNEMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQ 390

  Fly   291 LMTEQQQLLREKTK-LDLTIVDLNDEVQGDNKSKERADQELKNL----KVTI-----------AE 339
            |..|..| :|||.| .......|..::|   |.||:. :|||::    |..|           .|
Mouse   391 LDLEDVQ-VREKLKHATSKAKKLEKQLQ---KDKEKV-EELKSVPAKSKTVINETTTRNNSLEKE 450

  Fly   340 REKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELY-----AKQGRGSQFSSREDRDKWITNEL 399
            ||||...:|...:::|::.:...:|   ||.:.|||.     ..:.|.....::.:.|.:::...
Mouse   451 REKEEKKLKEVMDSLKQETQGLQKE---KEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHN 512

  Fly   400 KSISKQTRDKIAHHAKLV---EDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKT 461
            .::|:.::.|.|    |:   |.||:...:.||:..|:.:...||:       |..|:..:|.:.
Mouse   513 TAVSQLSKAKEA----LITASETLKERKAAIKDINTKLPQTQQELK-------EKEKELQKLTQE 566

  Fly   462 KDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQS 526
            :...:|:.::|::            |.|.:::..|:....|           ||||:.::. .:|
Mouse   567 EINLKSLVHDLFQ------------KVEEAKSSLAMNRSRG-----------KVLDAIIQE-KKS 607

  Fly   527 AEIARAY-----YGPVIENFS------CDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKL 580
            ..|...|     .|.:.|.:.      |....|..|:          .:::..|....||:.|  
Mouse   608 GRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVD----------SIDTAQECVNFLKKHN-- 660

  Fly   581 KLPGEVTFMPLNRLQV------KIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLER 639
              .|..||:.|:::.|      ||....:.|....:: |:| :|:..:|..:....||:..||::
Mouse   661 --IGIATFIGLDKMTVWAKKMSKIQTPENTPRLFDLV-KVK-NEEIRQAFYFALRDTLVANNLDQ 721

  Fly   640 ATELA--KSTGLDCVTLDGDQVSSKGSLTGG--------------------YFNTSRSRLEMQKK 682
            ||.:|  :......|||.|..:...|:::||                    ..|...|:||...|
Mouse   722 ATRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEISVEEVNKMESQLERHSK 786

  Fly   683 RT-EYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEEL 746
            :. :...|..:.|:.:.|||:..:...|.:....:.:|....::       |.:..:|:.::..:
Mouse   787 QAMQIQEQKVQHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQE-------EYLCVQIKELEANV 844

  Fly   747 VRIEQYRAPK---ERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLN 808
            :.....|..:   |.:::..|...:::......:|||:|: |.:|:...:.|::....:.:..:|
Mouse   845 LTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKR-LHNTIIDINNRKLKAQQNKLDTIN 908

  Fly   809 QENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRI 873
            ::..|..:...:.:|.....|    .||.:.:|.:.:..:||  :|.::::|:.||||.:.|.:.
Mouse   909 KQLDECASAITKAQVAIKTAD----RNLKKAQDSVCRTEKEI--KDTEKEINDLKTELKNIEDKA 967

  Fly   874 KKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDS----KQLEKWSTKENMLNE 934
            ::|.::.:..|..:.|..:..:.|.|||:.    .:|.|..|.||:    .:||:.....:..|.
Mouse   968 EEVINNTKTAETSLPEIQKEHRNLLQELKV----IQENEHALQKDALSIKLKLEQIDGHISEHNS 1028

  Fly   935 KIDECTEKIASLGAVPLVD-PSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEK 998
            ||....::|:.:...|:.| |..|...|..  :|||.    :|....:..:.........|.|..
Mouse  1029 KIKYWQKEISKIKLHPVEDNPVETVAVLSQ--EELEA----IKNPESITNEIALLEAQCREMKPN 1087

  Fly   999 L-----YRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLIL-- 1056
            |     |::||:|.:  |::      .|:.|:.:.:..|||..::..|  ::|....|||.::  
Mouse  1088 LGAIAEYKKKEDLYL--QRV------AELDKITSERDNFRQAYEDLRK--QRLNEFMAGFYVITN 1142

  Fly  1057 KTKDNE-----GDEMEKE-VENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQ 1115
            |.|:|.     |.:.|.| |::.|.|:. ||..|....:...:::..||||:|:|.:|||:|::.
Mouse  1143 KLKENYQMLTLGGDAELELVDSLDPFSE-GIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALH 1206

  Fly  1116 KCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGV 1172
            ...|.|.|..||||.|||..:...||..|:|.:..||||..:.|..:.|.:.:..|:
Mouse  1207 HYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 308/1292 (24%)
ABC_SMC3_euk 3..>159 CDD:213239 52/176 (30%)
SMC_hinge 533..643 CDD:214944 28/126 (22%)
TMPIT 678..>760 CDD:285135 13/85 (15%)
CHD5 <780..>822 CDD:282299 7/41 (17%)
P-loop_NTPase <1088..1182 CDD:304359 31/85 (36%)
Smc4NP_598547.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51
SMC_N 81..1272 CDD:308206 308/1292 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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