DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and Smc1a

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_113871.2 Gene:Smc1a / 63996 RGDID:61991 Length:1233 Species:Rattus norvegicus


Alignment Length:1330 Identity:319/1330 - (23%)
Similarity:589/1330 - (44%) Gaps:290/1330 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            :|.|.|:.|||||.:.::.|| :|...::|.|||||||...||.|||.::.::||.:..:.|:| 
  Rat     4 LKLIEIENFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIH- 66

  Fly    68 GTGARV-----ISAYVEIIF--DNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLL 125
              ||.|     ..|:|.:::  :.:::|.       |.|.::|. ..:|.:|.|||..:|....|
  Rat    67 --GAPVGKPAANRAFVSMVYSEEGAEDRT-------FARVIVGG-SSEYKINNKVVQLHEYSEEL 121

  Fly   126 ESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT----RVYDERKEESLNLLRETDSKV 186
            |..|.......::|.||.:..:|......|..|..|::.:    :.||:||:|.:....:|....
  Rat   122 EKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNY 186

  Fly   187 EKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQR--KSS 249
            .:    .|.|....:..::||||...||     |...|.:|.:.:|:..|...:|:::::  |..
  Rat   187 HR----KKNIAAERKEAKQEKEEADRYQ-----RLKDEVVRAQVQLQLFKLYHNEVEIEKLNKEL 242

  Fly   250 SDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLND 314
            :.|.|    ||:|.::::..|:..|||.||       |...:|.||||:.:|..:.|   .:||.
  Rat   243 ASKNK----EIEKDKKRMDKVEDELKEKKK-------ELGKMMREQQQIEKEIKEKD---SELNQ 293

  Fly   315 EVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQ 379
            :.....|:||....::|.|:..    :|.|.:.:..|:..|...::..:|:...|:.|:|...:.
  Rat   294 KRPQYIKAKENTSHKIKKLEAA----KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM 354

  Fly   380 GRGSQFSSREDRDKWIT---NELKSISKQTRDKIAHHAKLVEDLKK---DATSEKDL-----GQK 433
            ...||...|:     :|   |::|...:...:.....|.|.::|:|   |..:::|.     .:|
  Rat   355 EEESQSQGRD-----LTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKK 414

  Fly   434 IEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALR 498
            :|..:...::|| :|:|:.|:..:|::.....:....|..:.|.::|::::..|..:...::.|.
  Rat   415 VETEAKIKQKLR-EIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELN 478

  Fly   499 SMAGKPILNGCDSVRKVLDSFVERGGQSAE---------IARAY----YGPVIENFSC---DKTI 547
            .:           :.::.|:.::|...|.:         |.|.|    ||.:|:  .|   .|..
  Rat   479 QV-----------MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLID--LCQPTQKKY 530

  Fly   548 YTAVEVTAANRLFHHIVESEYEG---TQILKEMNKLKLPGE-VTFMPLNRLQVKIHDYPDD---- 604
            ..||.......:...||:||..|   .|.:||..     || .||:||:.|:||    |.|    
  Rat   531 QIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQR-----GEPETFLPLDYLEVK----PTDEKLR 586

  Fly   605 --PDSIPMISKLKYDEQH-DKALRYIFGKTLICRNLERATELA-------KSTGLDCVTLDGDQV 659
              ..:..:|..::|:..| .|||:|..|..|:|.|:|.|..:|       |:     |.|||...
  Rat   587 ELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKT-----VALDGTLF 646

  Fly   660 SSKGSLTGGYFN-TSRSRL-------EMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSI-- 714
            ...|.::||..: .:::|.       ::::|:...|.::.| :.|..:...||:..::..:.:  
  Rat   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKE-QMKAKRKEAELRQVQSQAHGLQM 710

  Fly   715 -----VSEMQKTETK------QGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLE 768
                 .|::::|:|:      |.||     |::.|:......:..|::....:||.:...|..: 
  Rat   711 RLKYSQSDLEQTKTRHLALNLQEKS-----KLESELANFGPRINDIKRIIQSREREMKDLKEKM- 769

  Fly   769 SMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLL- 832
                  :.:|.|:.:|....:..::.||.::  :.::|.|:..|    :|::||.:|.:|...| 
  Rat   770 ------NQVEDEVFEEFCREIGVRNIREFEE--EKVKRQNEIAK----KRLEFENQKTRLGIQLD 822

  Fly   833 --INNLFRRRDEL-------------IQALQEIS------VEDRKRKLNNCKTELVSAEKRIKKV 876
              .|.|...:|::             |:.|::..      :::...:|.:.|.:.::.:..:...
  Rat   823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDK 887

  Fly   877 NSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTE 941
            |.::|||.|::..|   .||:     ||::||..|.|     :|..:|.|.:.|:|    ..|..
  Rat   888 NHEMEEIRKKLGGA---NKEM-----THLQKEVTAIE-----TKLEQKRSDRHNLL----QACKM 935

  Fly   942 KIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKE-- 1004
            :...|   ||     ::.::.:|.:| |..:|.            ::.:|.|::...:|.|:.  
  Rat   936 QDIKL---PL-----SKGTMDDISQE-EGGSQG------------EESVSGSQRTSSIYAREALI 979

  Fly  1005 ELDIGD---------------QKIHMLIQSLE----------------MQKVEAIQFTFRQVAQN 1038
            |:|.||               |:::.|.|.|.                |:|:|:::..|::.:..
  Rat   980 EIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044

  Fly  1039 FTKVFKKLVPMGAGFLILKTKDNEG------------DEMEKEV---ENSDAFTG---------I 1079
            |....|:.......|..:|.:..:.            ||:.|.:   .::.||.|         .
  Rat  1045 FEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLD 1109

  Fly  1080 GIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMI 1144
            ||..:........|.|:.||||:|::.||||:|:|....||||::.||||.|||..:...|||.|
  Rat  1110 GINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYI 1174

  Fly  1145 HELSDTAQF--ITTTFRPELLENAHKFYGV 1172
            .|.| |..|  |..:.:.|....|....||
  Rat  1175 KEQS-TCNFQAIVISLKEEFYTKAESLIGV 1203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 319/1330 (24%)
ABC_SMC3_euk 3..>159 CDD:213239 51/162 (31%)
SMC_hinge 533..643 CDD:214944 40/127 (31%)
TMPIT 678..>760 CDD:285135 17/94 (18%)
CHD5 <780..>822 CDD:282299 8/41 (20%)
P-loop_NTPase <1088..1182 CDD:304359 37/87 (43%)
Smc1aNP_113871.2 SMC_N 3..1210 CDD:308206 319/1330 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..307 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..369 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..969 6/35 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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