Protein Alignment SMC3 and smc5

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001180470.1
• Gene: smc5 / 566749
• ZFINID: ZDB-GENE-061013-288
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1262
• Identity: 258/1262 - (20%)
• Similarity: 465/1262 - (36%)
• Gaps: 368/1262 - (29%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |.:|.:..|.:| |.:.|.|..|. |::||.||:|||:...||...|:.:.:.|
Zfish    42 IVRITMHNFLTY-DHSEVFPGPKL-NMIVGANGTGKSSIVCAICLGLAGKTSVL----------- 93

  Fly    68 GTGARVISAYVEIIFDNSDNRVPIDKE------EIFLRRVIGAKKDQ--YFLNKKVVPRNEVVNL 124
            |.|.:| ..||:    ....|..::.|      .:.:.|.|..:.:|  :.||||...:..|...
Zfish    94 GRGDKV-GLYVK----RGCQRGSVEIELYRTRGNLIVTREIQVENNQSTWMLNKKHASQKAVEEA 153

  Fly   125 LESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKI 189
            :........|....:.|.|:.:.|..::|                       .||..|:..|...
Zfish   154 VRELHIQVGNLCQFLPQEKVGEFAKMSNS-----------------------ELLEATEKSVGPP 195

  Fly   190 SEY-----LKTIEDRLQTLE---EEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQR 246
            ..|     |||...:.:.||   :||....|..:....|..|:..||..:    |:.||.:|:
Zfish   196 EMYEFHCELKTFRTKERDLENVCKEKGNFLEKARQRNERNKLDVERYYMK----KRHLDRIQM-- 254

  Fly   247 KSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVD 311
               .:|||.: :|.:.|:::::.|:|...|.|:|::..||.:..|:.:.:.:..|...::..:.:
Zfish   255 ---LEKKKPW-VEYETARKELEGVKKERDEMKRKLRFLKEAQEPLLRKIRSVESELQPIEQQMKE 315

  Fly   312 LNDEV-QGDNKSKERADQ-ELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKE 374
            :.:.: :...|.|::.|| ||||         ||:||:|              :::.||:
Zfish   316 MTNRIKEATQKCKQKHDQLELKN---------KEVDDIK--------------QDMSLKQ----- 352

  Fly   375 LYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSE---KDLGQKIEE 436
                       :...||.|               :|.|...::.||:|:..:.   :|:..:||.
Zfish   353 -----------TEEADRQK---------------RIGHTQLMIRDLQKELQNMGTIEDVTPQIEA 391

  Fly   437 HSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMA 501
            .::||..::.:......:..:|::.||       |:..:..::..:|::..:.:...::.|||..
Zfish   392 INAELRNIQEERARLESESLDLRRDKD-------EITGEFARLQNRLRSLDDMMKIKEEKLRSRF 449

  Fly   502 GKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPV---------IENFSCDKTIYTAVEVTAAN 557
             :......:.:||..|              .|.|.|         :.:....|.|.|.:.|   |
Zfish   450 -RDTYTALEWLRKNRD--------------RYEGVVHEPMMLVINVRDARHAKYIETHISV---N 496

  Fly   558 RLFHHIVESEYEGTQILKEM--------NKLKLPGE-----------VTFMPLNRL--------- 594
            .|...:.:.:.:..:.:.||        |.:..|.|           .|..|...:
Zfish   497 DLRAFVFQRQDDNDKFMNEMRDTQRLRVNSIIAPTESCSKRPPSRPIETLKPYGFISYLREMFDA 561

  Fly   595 ----------QVKIHDYPDDPDSIP-MISKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTG 648
                      |.:::|.|...:... ||..:..|.|    ||.|:       ..|....:.||
Zfish   562 PEEVMSYLCHQYRVNDVPIGTEKTKGMIESVIKDLQ----LRTIY-------TAEERYNVKKS-- 613

  Fly   649 LDCVTLDGDQVSSKGSLTGGYFNTS------RSRLEMQKKRTEYTSQ--------IAEFEKKLSK 699
                ....:.|||..:|....|.|:      |.:||.|.:..|...|        |.|.:..|.:
Zfish   614 ----AYSNNVVSSNSALRPPQFLTTTIDVEERRQLEEQLRAAERQKQSIDQRMAAIREQQANLDR 674

  Fly   700 LRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKV-QGEIRLMKEELVRIEQYRAPKERSLAQC 763
            ..|||::.:..::.:.|:.::.|.|....:|...:: |.||     .||.||:....|..::...
Zfish   675 RDNELRANKKKLSDLKSKKRQLEQKISTKQDSLRQMEQNEI-----NLVAIEEEANAKIAAVNNK 734

  Fly   764 KASL--ESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKN 826
            |.::  |.::..:|.....:::..::..|:....|..:|..|:|..:.|.|.|       ||...
Zfish   735 KVTIMGEYLSHLQSKARLNMEKVYLALQSAGLSAEKTKLETDVRESSAELKRA-------EVDYT 792

  Fly   827 KLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAV 891
            |||.:..|.|.                       .||| |:.....|..:......:.:.:..|.
Zfish   793 KLDKIKTNLLM-----------------------TCKT-LMKRASEICNMTPGETAVPEELHAAF 833

  Fly   892 QLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSY 956
            .|..|...|::.                           ||||   |.|......|....|...|
Zfish   834 SLLPETLDEIDA---------------------------MLNE---ERTRAECFTGLSDAVVDEY 868

  Fly   957 TR--MSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQS 1019
            .|  ..:||:.|||:.....|..|..          :.:|.||:.....::|
Zfish   869 NRREQEIKNLEKELDDKTNELTTYRR----------NIAEAKERWLNPLKKL------------- 910

  Fly  1020 LEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVS 1084
                 ||.|...|....|:.         ..||            |::...||.:.:...|||
Zfish   911 -----VELINVRFSDFFQSM---------QCAG------------EVDLHSENEEEYDKYGIR-- 947

  Fly  1085 FTGVEAEMR---EMNQL-----SGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVA 1141
               ::.:.|   .|::|     |||::|:..:..:.|:|:.:..||.:.|||:|.:|.::.:.|.
Zfish   948 ---IQVQFRRNTRMHELTPHHQSGGERSVTTMLYLMSLQELNRCPFRVVDEINQGMDPVNERRVF 1009

  Fly  1142 NMIHELS---DTAQFITTTFRPELLEN 1165
            :::...:   :|:|:...|  |:||:|
Zfish  1010 DIVVRAACGVNTSQYFFIT--PKLLQN 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	258/1262 (20%)
		ABC_SMC3_euk	3..>159	CDD:213239	40/163 (25%)
		SMC_hinge	533..643	CDD:214944	27/157 (17%)
		TMPIT	678..>760	CDD:285135	22/90 (24%)
		CHD5	<780..>822	CDD:282299	8/41 (20%)
		P-loop_NTPase	<1088..1182	CDD:304359	24/89 (27%)
smc5	NP_001180470.1	ABC_SMC5_euk	40..>185	CDD:213244	40/183 (22%)
		Smc	42..1030	CDD:224117	254/1256 (20%)
		ABC_SMC5_euk	<950..1052	CDD:213244	24/87 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810