DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and smc1a

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001155103.1	Gene:	smc1a / 559665	ZFINID:	ZDB-GENE-090506-9	Length:	1232	Species:	Danio rerio

Alignment Length:	1326	Identity:	319/1326 - (24%)
Similarity:	565/1326 - (42%)	Gaps:	280/1326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLH 66
            ::|.|.|:.|||||.:.::.||.| ...::|.|||||||...||.|||:::.::||.:..:.|:|
Zfish     3 YLKLIEIENFKSYKGRQIIGPFHK-FTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIH 66

  Fly    67 EGTGARV-----ISAYVEIIF--DNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNL 124
               ||.|     ..|:|.:::  ||.:       |..|.|.:||: ..:|.:|.|||..::....
Zfish    67 ---GAPVGKPAANRAFVSMVYCEDNGE-------ECTFTRAIIGS-SSEYRINSKVVGLSDYSEE 120

  Fly   125 LESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT----RVYDERKEESLNLLRETDSK 185
            ||..|.......::|.||.:..:|......|..|..|::.:    :.||.||:|.:....:|...
Zfish   121 LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDRRKKEMVKAEEDTQFS 185

  Fly   186 VEKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSS 250
            ..:    .|.|....:..::||||.:.||     |...|.:|...:|:..|...:|.::::.:..
Zfish   186 YHR----KKNIAAERKEAKQEKEEAERYQ-----RLKDEVVRAHVQLQLFKLYHNEEEIEKLNRE 241

  Fly   251 DKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDE 315
            ..::  |.||.|.::|:..|::.||:.||       |...:|.:||.:.:|..:.|   .:||.:
Zfish   242 LSQR--NREIDKDRKKMDHVEEELKDKKK-------ELGRMMRDQQNVEKEIKEKD---AELNQK 294

  Fly   316 VQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAK-- 378
            .....|:||....::|.|:|.    .|.|.:.:..|:..|...|:..||....|..|:|...:
Zfish   295 RPQYIKAKENTAHKIKKLEVA----RKSLQNAQKMYKKRKADIEELDREQGAVEMSRQEFEERME 355

  Fly   379 ---QGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKK---DATSEKDL-----GQ 432
               |.:|...:..|       |::|...:...:.....|.|.::|:|   |..:::|.     .:
Zfish   356 EEAQSQGQDLTLEE-------NQVKQYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERK 413

  Fly   433 KIEEHSSELEQLRLQIDEHNKKYYELKKTKD----QHQSMRNELWRKETQMTQQLQTHKEELSRA 493
            |||..:...:::| :|:|:.|:   ::|.:|    ..||: :|..|.|.::|::::..|..:...
Zfish   414 KIETEAKIKQKIR-EIEENQKR---IEKLEDYIATSRQSL-DEQRRMEEELTEEVELAKRRIDEI 473

  Fly   494 DQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAE---------IARAY----YGPVIENFSC-- 543
            :..|..:           :.::.|:.::|...|.:         |.|.|    ||.:|:  .|
Zfish   474 NMELNQV-----------MEQLGDARIDRQENSRQQRKAEIMESIKRLYPGSVYGRLID--LCQP 525

  Fly   544 -DKTIYTAVEVTAANRLFHHIVESEYEG---TQILKEMNKLKLPGE-VTFMPLNRLQVKIHDYPD 603
             .|....||.......:...||:||..|   .|.:||..     || .||:||:.|:||    |.
Zfish   526 TQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQR-----GEPETFLPLDYLEVK----PT 581

  Fly   604 DP------DSIPMISKLKYDEQH-DKALRYIFGKTLICRNLERATELA-------KSTGLDCVTL 654
            |.      .:..:|..::|:..| .|||:|..|..|:|.|:|.|..:|       |:     |.|
Zfish   582 DEKLRELRGAKLVIDVIRYEPPHIKKALQYACGNALVCENVEDARRIAFGGPYRHKT-----VAL 641

  Fly   655 DGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQ 719
            ||......|.::||     .|.|:.:.:|.: ...:.:.::|..||..|||           |..
Zfish   642 DGTLFQKSGVISGG-----ASDLKAKARRWD-EKAVDKLKEKKEKLTEELK-----------EQM 689

  Fly   720 KTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLA---QCKASLESMTSTKSSLEAEL 781
            |.:.|:.:.:.|..:..|....:|.....:||   .|.|.|:   |.|:.|||..:.......::
Zfish   690 KAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQ---TKTRHLSLNMQEKSKLESELANFGPRINDI 751

  Fly   782 KQELMSTLSSQDQREIDQLND--------------------DIRRLNQE----NKEAFTQRMQFE 822
            |:.:.|.     :|:|.||.|                    :||...:|    ..|...:|::||
Zfish   752 KRIIQSR-----ERDITQLRDRMNLVEDEVFFEFCKEIGVRNIREFEEEKVKRQNEIAKKRLEFE 811

  Fly   823 VRKNKL---------------DNLLINNLFRRRDELIQALQEISVEDRKR---------KLNNCK 863
            .:|.:|               :.:::.....::||  ..::.:..|:.:.         :|.:.|
Zfish   812 TQKTRLAIQLDYEKNQLKEDQEKVMMWEQTVKKDE--NEIERLKKEEHRHMKIIDETMAQLQDLK 874

  Fly   864 TELVSAEKRIKKVNSDLEEIEKRV----MEAVQLQKELQQELETHVRKEKEAEENLNK------- 917
            .:.::.:..:...|.::|||.|::    .|..|||||: ..:||.:.:::....||.:
Zfish   875 NQHLTKKGEVNDKNREMEEIRKKLGSANKELTQLQKEV-TAIETKLEQKRSDRHNLLQACKMQDI 938

  Fly   918 ----------DSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKE----- 967
                      |..|.|..|..|:.::.  .:.:..:.:..|:..:|.|.....||:...|
Zfish   939 KLPLKSGTMDDISQGEGGSQVEDAISS--PKASSSVHAKEALIEIDYSNLNEDLKDALSEDEIKG 1001

  Fly   968 --------LEKANQHLKKYNHVNKKAL-------DQFLSFSEQKEKLYRRKEELDIGDQKIHMLI 1017
                    |.:....|::.:..|.||:       |:|...|::.|...:|.       :|.....
Zfish  1002 EMNTLQQRLNEQQSILQRISAPNMKAMEKLESVRDKFQETSDEFEAARKRA-------KKAKQAF 1059

  Fly  1018 QSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIR 1082
            :.::.::.:.....|..||.|..:::|.|....:....|..::.|...::            ||.
Zfish  1060 EQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLD------------GIN 1112

  Fly  1083 VSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHEL 1147
            .:........|.|:.||||:|::.||||:|:|....||||::.||||.|||..:...|||.|.:.
Zfish  1113 YNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKDQ 1177

  Fly  1148 S-DTAQFITTTFRPELLENAHKFYGV 1172
            | ...|.|..:.:.|....|....||
Zfish  1178 SVQNFQAIVISLKEEFYTKADSLIGV 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	319/1326 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	53/162 (33%)
		SMC_hinge	533..643	CDD:214944	40/127 (31%)
		TMPIT	678..>760	CDD:285135	17/81 (21%)
		CHD5	<780..>822	CDD:282299	12/65 (18%)
		P-loop_NTPase	<1088..1182	CDD:304359	35/86 (41%)
smc1a	NP_001155103.1	SMC_N	3..1208	CDD:280601	319/1326 (24%)
		ABC_SMC1_euk	4..>148	CDD:213242	52/155 (34%)
		SMC_hinge	513..628	CDD:214944	39/125 (31%)
		ABC_SMC1_euk	<1117..1220	CDD:213242	35/87 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810