Protein Alignment SMC3 and si:dkey-119f1.1

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001121806.1
• Gene: si:dkey-119f1.1 / 557127
• ZFINID: ZDB-GENE-070705-287
• Length: 1090
• Species: Danio rerio
• Alignment Length: 1227
• Identity: 247/1227 - (20%)
• Similarity: 487/1227 - (39%)
• Gaps: 296/1227 - (24%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNV--VVGRNGSGKSNFFYAIQFVLSDE-FTHLRPEQRQSL 64
            |:.|.::.|..:   :::.||....||  |||.||||||....|:...|..: .|..|....:..
Zfish    52 IESISLRNFMCH---SLLGPFAFGPNVNFVVGNNGSGKSAVLTALIVALGGKALTTNRGSSLKGF 113

  Fly    65 LHEGTGARVIS---------AYVEIIFDNS---DNRVPID-----KEEIFLRRVIGAKKDQYFLN 112
            :.||..:..:|         ||....|..|   |.|:..:     |.:....:::.|||:
Zfish   114 VKEGESSADVSITLRNRGRDAYKPEKFGQSIVVDLRISSEGIRTYKLKSHTGQLVSAKKE----- 173

  Fly   113 KKVVPRNEVVNLLESAGFSSSNPYYIVKQGKINQMATA---ADSYRLKLLREVAGTRVYDERKEE 174
                   |:|::|:.......||..|:.|........:   .|.|:..:             |..
Zfish   174 -------ELVSILDHFNIQVDNPVSILTQEMSKHFLHSKGEGDKYKFFM-------------KAT 218

  Fly   175 SLNLLRETDSKVEKISEYLK-TIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKA 238
            .|:.::|..|.:.|.....: |:|...:||.|.|::.::.::           ||:     :..:
Zfish   219 QLDQMKEDYSYIMKTKTLTQNTVEKHRETLLELKQKFRDKEE-----------RYK-----SLAS 267

  Fly   239 LDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKT 303
            |||:|         :|:..::.|.|...:.::::.:|..|:::  |.||||.:
Zfish   268 LDEMQ---------QKLNELKNQMAWALVAEMEQEMKPMKEQI--TAEERSTV------------ 309

  Fly   304 KLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLK 368
            |.|..:.:...:|...||..::...:|:    :::||.::|   :|:...:|.:.::.:|||:..
Zfish   310 KYDQKVEEWKGKVDEANKISKQLQDQLE----SVSERMQQL---QPECSELKSRVQERNRELKTA 367

  Fly   369 E----QKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTR-DKIAHHAKLVEDLK-KDATSE 427
            |    :||..|...:....|.:.|....|...:::.|...|.| :|:.|....:|:|. :|:|
Zfish   368 EAALHRKRTNLRDLEKDKDQLNKRIKELKHSISQMNSADTQARVEKMNHIQAELEELSFRDST-- 430

  Fly   428 KDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSR 492
              |.|:|::.....|..:.:....:::..:|::..|   |.:.:|...|:....||:...|.:..
Zfish   431 --LAQQIDQFKQACESAKERHARMSRERQDLQRAID---SKQRDLAAMESSRNNQLRRFGEHIPA 490

  Fly   493 ADQAL------RSMAGKPI--LNGCDSVR-KVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIY 548
            ..:|:      .....||:  |..|..:| :.|...||...::..:|          |.||
Zfish   491 LMEAIDEAHHRGKFRMKPVGPLGFCIRLRDQDLALAVECCLKALMLA----------FCCD---- 541

  Fly   549 TAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHD-------YPDDPD 606
                        :|..|.|.|     :.|.:....|....:.::|....:::       :||.|.
Zfish   542 ------------NHADERELE-----RIMGRFYQRGRRPQIIVSRFTNMLYNVGNRAVSHPDYPT 589

  Fly   607 SI-------PMISKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTG-------LDCVTLDGD 657
            .:       |:::....|.:..:.:       |:.::...|..:.:|.|       .:..|.|||
Zfish   590 VLQALDIENPVVANCLIDMRGIETI-------LLIKDNRDARRVMQSKGGQAPRNCREAFTRDGD 647

  Fly   658 QVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTE 722
            ||     .|..|:::.:.|.:...:..|  .:|...:..|...|.:|...:.::..:..|.::.:
Zfish   648 QV-----YTNRYYSSEQHRAQYLSRDVE--EEIRHLQSALQTQRAQLDRFQQDMQQVGEEERQNQ 705

  Fly   723 TKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMS 787
            |...::.|..:|||...|.::.||..::....|:...|              ..||.|| :||..
Zfish   706 TLLRRAYDDRKKVQERSRKLQAELTELQNVEEPQSEDL--------------KPLEEEL-EELSG 755

  Fly   788 TLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISV 852
            .:|...: |.:.|....:...:|.:||                   ..:||::.|.:.::.| .|
Zfish   756 RISVCGE-EFEALRRQTQTCKKEYEEA-------------------EKVFRQKKEAVNSIVE-EV 799

  Fly   853 EDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQK----ELQQELETHVRKEKE--- 910
            |..|.:|||...|:    :|.|......||..|..::.::..|    :.:|||:..:.|..|
Zfish   800 EPIKERLNNSDQEV----ERSKHHRKHYEEKRKTHLQMIETLKTSLNQKEQELQAAIAKASEICP 860

  Fly   911 AEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHL 975
            ...::.:.:|.|:   ::.|.|..||:  |::          |....|   ..|.:|..:|.:
Zfish   861 ERSDVRRTAKSLD---SEINRLKSKIN--TQQ----------DQQGHR---DTIVREYHEARE-- 905

  Fly   976 KKYNHVNK--KALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQN 1038
             |:..:::  |.||.|:   .|..|:...:          |.:...:.|......::.|..:...
Zfish   906 -KFGKISRQVKGLDAFI---HQLSKIMTTR----------HNVYAEMRMYLSVRCKYNFHSMLSQ 956

  Fly  1039 FTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQK 1103
              :.:|       |.:|.   |::.:.:...|:..:            |.:|::.:|..||||::
Zfish   957 --RGYK-------GKMIF---DHKNEILSISVQPGE------------GGKADLSDMRSLSGGER 997

  Fly  1104 SLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDT---AQFITTT 1157
            |...:..:.|:.:....||...||.|..:|.::|:...:|:.:::.:   .|||..|
Zfish   998 SFSTVCFVLSLWEIAEVPFRALDEFDVYMDMVNRRISMDMMLKIAASQRYRQFIFLT 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	247/1227 (20%)
		ABC_SMC3_euk	3..>159	CDD:213239	42/178 (24%)
		SMC_hinge	533..643	CDD:214944	17/123 (14%)
		TMPIT	678..>760	CDD:285135	15/81 (19%)
		CHD5	<780..>822	CDD:282299	10/41 (24%)
		P-loop_NTPase	<1088..1182	CDD:304359	20/73 (27%)
si:dkey-119f1.1	NP_001121806.1	Smc	52..1074	CDD:224117	247/1227 (20%)
		ABC_SMC6_euk	52..>208	CDD:213243	40/170 (24%)
		TBPIP	<241..319	CDD:284512	23/116 (20%)
		Laminin_II	319..>396	CDD:283628	18/83 (22%)
		ABC_SMC6_euk	<982..1077	CDD:213243	20/73 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810