Protein Alignment SMC3 and SMC6

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Alignment Length: 1210
• Identity: 252/1210 - (20%)
• Similarity: 460/1210 - (38%)
• Gaps: 330/1210 - (27%)

  Fly    23 FDKRHNVVVGRNGSGKSNFFYAIQFVL--SDEFTHLRPEQRQSLLHEGTGARVISAYVEIIFDNS 85
            |....|.:||.||||||....|:...|  |...|: |....|.|:..|.    :||.:.|...||
  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLTSSARATN-RASSIQKLIKNGE----VSATISITLSNS 176

  Fly    86 DNRVPIDKEEIF-----LRRVIGAKKDQYFL--------NKKVVPRNEVVNLLESAGFSSSNPYY 137
            ..| |. |.:||     :.|.|......|.|        :|||   :::..:|...|.:..||.:
  Fly   177 GLR-PF-KADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKV---SDIRRMLLCFGINVENPIF 236

  Fly   138 IVKQGKINQM---ATAADSYRLKL-----------LREVAGTRVYDERKEESLNLLRETDSKVEK 188
            ::.|....:.   ...|.:|:|.:           |.|....|.:..::.|.|      :.|.|.
  Fly   237 VLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQL------EKKKEM 295

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTR----------RTLEYIRYETELKDTKKALDELQ 243
            :.:::...|::|..| |:||.:||..:..||:          ..|..:.:..:|.:.|||..|..
  Fly   296 MIKHIAAEEEKLSIL-EDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQT 359

  Fly   244 LQRKSSSD---KKKIYNIEIQK----AQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLRE 301
            ..:|.|:.   .:|:...|..|    |.:|.:|  :.||.|||.||.       |:.|..|:
  Fly   360 TSKKESTQATMNQKLKEFEASKNQILATQKFQD--ERLKTAKKAVQD-------LLLEASQV--- 412

  Fly   302 KTKLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAM-KRKEEDCSREL 365
            |.|:            |:.:.:.|.||.      :..|.||.:.:....:..: :::||:.::..
  Fly   413 KAKI------------GNAERRMREDQR------SYDECEKLIGNYHADFNRVNEQREENANKIE 459

  Fly   366 QLKEQ--KRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEK 428
            .||:|  |.:|:.| |.|..|                                 :::|:|.||
  Fly   460 MLKKQVVKSEEIIA-QLRAEQ---------------------------------QEIKRDITS-- 488

  Fly   429 DLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKET---QMTQQLQTHKEEL 490
                 ::|....::..|:|:                |:|.:|..|..|.   ..:.:|..:.|:.
  Fly   489 -----VQERLDAVKNGRIQL----------------HKSKQNISWEIEALSRNKSNKLSVYGEQT 532

  Fly   491 SRADQALRSMAGKPILNGCDSVRKVLDSFVERG--GQSAEIARAYYGPVIENFSCDKTIYTAVEV 553
            .:...|||:...     |.:..|      :.||  ||........|..:||
  Fly   533 IQVVHALRTQYA-----GSNMHR------MPRGPLGQYISAPNPKYRDLIE-------------- 572

  Fly   554 TAANRLFH----HIVESEYEGTQILKEMNKLKLPG-------------EVTFMPLNRLQVKIHDY 601
               |:|.|    .||.|:.| .|.|:.:.:.|..|             .|..:..|::|
  Fly   573 ---NQLMHCLRSFIVGSDRE-RQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQ------ 627

  Fly   602 PDDPDSIPMISKLKYDEQHDKALRYIFG----KTLICRNLERATELAKSTGLDCVTLDGDQVSSK 662
            |..|::..:|.::..|:  ...:.|:..    :|::   :..:.|:|     :.:|.|.:.|..
  Fly   628 PTTPNTTVLIDEISCDD--PVVMNYLIDILRIETVL---VTESKEIA-----EFLTSDTENVPP- 681

  Fly   663 GSLTGGYFNTSRSRLEMQKKRTEY--TSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQ 725
             :||         |:.:.....||  :...|.:..:::..|...|:.::.|..:..|....:.|:
  Fly   682 -NLT---------RVLVPNLGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQMEQSDLQEKE 736

  Fly   726 G-------KSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQ 783
            .       :.|.|.|..|   :::.::...|.|:::..::::                      |
  Fly   737 PSLEIDYMQHKKVLENTQ---KVISQKSTMIGQHQSRNQKAM----------------------Q 776

  Fly   784 ELM--STLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDEL--I 844
            ::|  .....|:..|.|:|...:....::.::.   |::.|:.:.||  |.|.:   |:.||  .
  Fly   777 KIMELQNFDYQELPEYDRLKSHLADSGEKIEKC---RLEREMLQEKL--LSIQH---RQTELEST 833

  Fly   845 QALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEK 909
            :|.:..::|...:||....||....|.:::.::...||..:|..:.:||::::..|.||.:.:.:
  Fly   834 EAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSELE 898

  Fly   910 EAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQH 974
            :|.....|..:.:....|:|. :.|.|.....||..:..:. .:|......|..:..|||..::|
  Fly   899 KARTEAEKLGEFIATTQTEEK-IREAISRYKSKIKQVEELN-YNPEELERGLAELRDELELQSRH 961

  Fly   975 LKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNF 1039
            |...:.|.||....:    .|:.:|::|...        |....         :||.|.|...
  Fly   962 LAVVDSVVKKLRMAY----HQRAQLFQRSRH--------HYFTM---------VQFQFEQALA-- 1003

  Fly  1040 TKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKS 1104
            .:.||         :..:|.|.|      :....:.|...|...|.|         ..||||::|
  Fly  1004 MRQFK---------VSFETSDKE------KTWKINVFPPSGNETSNT---------RSLSGGERS 1044

  Fly  1105 LVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMI 1144
            ...::|:..:......|||..||.|...|.::||.:..::
  Fly  1045 FTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEIL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	252/1210 (21%)
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	40/140 (29%)
		SMC_prok_B	115..1076	CDD:274008	250/1200 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	18/67 (27%)