DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and jnj

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_651228.1	Gene:	jnj / 42876	FlyBaseID:	FBgn0266282	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	1210	Identity:	252/1210 - (20%)
Similarity:	460/1210 - (38%)	Gaps:	330/1210 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FDKRHNVVVGRNGSGKSNFFYAIQFVL--SDEFTHLRPEQRQSLLHEGTGARVISAYVEIIFDNS 85
            |....|.:||.||||||....|:...|  |...|: |....|.|:..|.    :||.:.|...||
  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLTSSARATN-RASSIQKLIKNGE----VSATISITLSNS 176

  Fly    86 DNRVPIDKEEIF-----LRRVIGAKKDQYFL--------NKKVVPRNEVVNLLESAGFSSSNPYY 137
            ..| |. |.:||     :.|.|......|.|        :|||   :::..:|...|.:..||.:
  Fly   177 GLR-PF-KADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKV---SDIRRMLLCFGINVENPIF 236

  Fly   138 IVKQGKINQM---ATAADSYRLKL-----------LREVAGTRVYDERKEESLNLLRETDSKVEK 188
            ::.|....:.   ...|.:|:|.:           |.|....|.:..::.|.|      :.|.|.
  Fly   237 VLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQL------EKKKEM 295

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTR----------RTLEYIRYETELKDTKKALDELQ 243
            :.:::...|::|..| |:||.:||..:..||:          ..|..:.:..:|.:.|||..|..
  Fly   296 MIKHIAAEEEKLSIL-EDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQT 359

  Fly   244 LQRKSSSD---KKKIYNIEIQK----AQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLRE 301
            ..:|.|:.   .:|:...|..|    |.:|.:|  :.||.|||.||.       |:.|..|:
  Fly   360 TSKKESTQATMNQKLKEFEASKNQILATQKFQD--ERLKTAKKAVQD-------LLLEASQV--- 412

  Fly   302 KTKLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAM-KRKEEDCSREL 365
            |.|:            |:.:.:.|.||.      :..|.||.:.:....:..: :::||:.::..
  Fly   413 KAKI------------GNAERRMREDQR------SYDECEKLIGNYHADFNRVNEQREENANKIE 459

  Fly   366 QLKEQ--KRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEK 428
            .||:|  |.:|:.| |.|..|                                 :::|:|.||
  Fly   460 MLKKQVVKSEEIIA-QLRAEQ---------------------------------QEIKRDITS-- 488

  Fly   429 DLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKET---QMTQQLQTHKEEL 490
                 ::|....::..|:|:                |:|.:|..|..|.   ..:.:|..:.|:.
  Fly   489 -----VQERLDAVKNGRIQL----------------HKSKQNISWEIEALSRNKSNKLSVYGEQT 532

  Fly   491 SRADQALRSMAGKPILNGCDSVRKVLDSFVERG--GQSAEIARAYYGPVIENFSCDKTIYTAVEV 553
            .:...|||:...     |.:..|      :.||  ||........|..:||
  Fly   533 IQVVHALRTQYA-----GSNMHR------MPRGPLGQYISAPNPKYRDLIE-------------- 572

  Fly   554 TAANRLFH----HIVESEYEGTQILKEMNKLKLPG-------------EVTFMPLNRLQVKIHDY 601
               |:|.|    .||.|:.| .|.|:.:.:.|..|             .|..:..|::|
  Fly   573 ---NQLMHCLRSFIVGSDRE-RQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQ------ 627

  Fly   602 PDDPDSIPMISKLKYDEQHDKALRYIFG----KTLICRNLERATELAKSTGLDCVTLDGDQVSSK 662
            |..|::..:|.::..|:  ...:.|:..    :|::   :..:.|:|     :.:|.|.:.|..
  Fly   628 PTTPNTTVLIDEISCDD--PVVMNYLIDILRIETVL---VTESKEIA-----EFLTSDTENVPP- 681

  Fly   663 GSLTGGYFNTSRSRLEMQKKRTEY--TSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQ 725
             :||         |:.:.....||  :...|.:..:::..|...|:.::.|..:..|....:.|:
  Fly   682 -NLT---------RVLVPNLGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQMEQSDLQEKE 736

  Fly   726 G-------KSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQ 783
            .       :.|.|.|..|   :::.::...|.|:::..::::                      |
  Fly   737 PSLEIDYMQHKKVLENTQ---KVISQKSTMIGQHQSRNQKAM----------------------Q 776

  Fly   784 ELM--STLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDEL--I 844
            ::|  .....|:..|.|:|...:....::.::.   |::.|:.:.||  |.|.:   |:.||  .
  Fly   777 KIMELQNFDYQELPEYDRLKSHLADSGEKIEKC---RLEREMLQEKL--LSIQH---RQTELEST 833

  Fly   845 QALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEK 909
            :|.:..::|...:||....||....|.:::.::...||..:|..:.:||::::..|.||.:.:.:
  Fly   834 EAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSELE 898

  Fly   910 EAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQH 974
            :|.....|..:.:....|:|. :.|.|.....||..:..:. .:|......|..:..|||..::|
  Fly   899 KARTEAEKLGEFIATTQTEEK-IREAISRYKSKIKQVEELN-YNPEELERGLAELRDELELQSRH 961

  Fly   975 LKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNF 1039
            |...:.|.||....:    .|:.:|::|...        |....         :||.|.|...
  Fly   962 LAVVDSVVKKLRMAY----HQRAQLFQRSRH--------HYFTM---------VQFQFEQALA-- 1003

  Fly  1040 TKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKS 1104
            .:.||         :..:|.|.|      :....:.|...|...|.|         ..||||::|
  Fly  1004 MRQFK---------VSFETSDKE------KTWKINVFPPSGNETSNT---------RSLSGGERS 1044

  Fly  1105 LVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMI 1144
            ...::|:..:......|||..||.|...|.::||.:..::
  Fly  1045 FTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEIL 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	252/1210 (21%)
		ABC_SMC3_euk	3..>159	CDD:213239	43/164 (26%)
		SMC_hinge	533..643	CDD:214944	23/130 (18%)
		TMPIT	678..>760	CDD:285135	14/90 (16%)
		CHD5	<780..>822	CDD:282299	7/43 (16%)
		P-loop_NTPase	<1088..1182	CDD:304359	15/57 (26%)
jnj	NP_651228.1	ABC_SMC6_euk	99..>248	CDD:213243	40/140 (29%)
		Smc	115..1084	CDD:224117	252/1208 (21%)
		TEX15	<269..>357	CDD:291972	22/94 (23%)
		ABC_SMC6_euk	<1027..1122	CDD:213243	18/67 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810