Protein Alignment SMC3 and SMC1

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 1336
• Identity: 317/1336 - (23%)
• Similarity: 565/1336 - (42%)
• Gaps: 313/1336 - (23%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            ::.|.::.||||:...||.|. |:.|.|:|.||||||||..||.||:.::.:.||.::...|:|.
  Fly    27 LEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90

  Fly    68 GTGARVI--SAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGF 130
            .:..:.:  |.||...|..::.| .:|    |.|.|||. ..:|.:|.:.|..:..:|.||..|.
  Fly    91 SSIGKPVSRSCYVTAKFVLNEER-HMD----FQRAVIGG-SSEYRINGESVSSSTYLNKLEKIGI 149

  Fly   131 SSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRV----YDERKEESLNLLRETD-------- 183
            :.....::|.||.:..:|......|..|..|::|:.:    |:..|:|.:....||.
  Fly   150 NVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKG 214

  Fly   184 -SKVEKISEYLKTIEDRLQTLEEE-KEELKEYQKW---------DKTRRTLEYIRYETE-LKDTK 236
             :...|.:::.|...||...|:.| .|:..|||.:         .|....||..:.|.: ::..|
  Fly   215 IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRK 279

  Fly   237 KALDELQLQRKSSSDK---------KKIYNIEIQ---------KAQEKIKDVQKNLKEAKKKVQS 283
            :|.||:..::|..:.|         ::|...|.|         ||:||:...:|.|...:|.:::
  Fly   280 EAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLET 344

  Fly   284 TKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKERAD---------QELKNLK----V 335
            .:|..:...::.::|  ||...|:..:....|.:.:|:|:.|..         ||...||    .
  Fly   345 AREADNAHQSDIRKL--EKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEA 407

  Fly   336 TIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELK 400
            |..:...|||.|.                   :||| .|.....|..::.:|.|:..|.:|.:.:
  Fly   408 TATQYRSELDSVN-------------------REQK-SEQDTLDGETNRRASVEESFKKLTLQRE 452

  Fly   401 SISKQTRDKIAHHAK-----------LVEDLKKDATSEKDLGQKIEEHSSELEQLRLQI-DEHNK 453
            ...|: |||:..|.|           :.::|::|..:.|   :||.|...|||.:|.|: |..:.
  Fly   453 EAVKR-RDKLMDHIKSSQAALEEQNRIKDELRRDVGTSK---EKIAEKQRELEDVRDQLGDAKSD 513

  Fly   454 KYYELKKTKDQHQSMRNELWRKET-----QMTQQLQ-THKEELSRADQALRSMAGKPILNGCDSV 512
            |:.:.::.|.|...   ||::|:.     :|....| |||    |.:.|               |
  Fly   514 KHEDARRKKKQEVV---ELFKKQVPGVYDRMINMCQPTHK----RYNVA---------------V 556

  Fly   513 RKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEM 577
            .|||..|:|                        .|....|.||     .|.:       |||||.
  Fly   557 TKVLGKFME------------------------AIIVDTEKTA-----RHCI-------QILKEQ 585

  Fly   578 NKLKLPGEV-TFMPLNRLQVKIHDYP--------DDPDSIPMI-SKLKYDEQH-DKALRYIFGKT 631
            ..     || ||:||:.||||    |        .||.::.:: ..||::.|. ::|:.:..|..
  Fly   586 ML-----EVETFLPLDYLQVK----PLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNA 641

  Fly   632 LICRNLERATELA---KSTGLDCVTLDGDQVSSKGSLTGGYFNTSR----------SRLEMQKKR 683
            |:|...|.|.::|   ..:..|.:.|||......|.::||..:.:|          ::|:|||:|
  Fly   642 LVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKER 706

  Fly   684 TEYTSQIAEFEKK------LSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLM 742
            .:  .::.|..||      |:.:.:::|..||.:...:.:::.::....:..:..::||.::...
  Fly   707 LQ--EELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEF 769

  Fly   743 KEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQEL-MSTLSSQDQREIDQLNDDIRR 806
            ..:::.||:....:|..:.:.|   |:|.:.:..:.|...:.| :..:...::||:....:..|:
  Fly   770 GPKILEIERRMQNREEHIQEIK---ENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARK 831

  Fly   807 LN--QENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSA 869
            ..  ::..::...::.||.:|:...|:              ...|.||:|.:..|...|.    |
  Fly   832 RAEFEQQIDSINSQLDFEKQKDTKKNV--------------ERWERSVQDEEDALEGLKL----A 878

  Fly   870 EKR-IKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNK------------DSKQ 921
            |.| :|:::.|.|::|| ..:..|.:|:...::|..:.|.::...||.|            :||.
  Fly   879 EARYLKEIDEDKEKMEK-FKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKI 942

  Fly   922 LEKWSTKENMLNEKIDECTEKIASLGAVPLV-----------DPSY--TRMSLKNI----FKELE 969
            ..|.:.::|:|.:...:|.       .|||:           ||..  |..:::||    :..|.
  Fly   943 EAKKNERQNILLQAKTDCI-------VVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLP 1000

  Fly   970 KANQHLKKYNHVNKKALDQFLSFSEQKEKLYR-RKEELDIGDQKIHMLIQSLEM---QKVEAIQF 1030
            :....||..:           :|.:..|.|.: .:.:||:.::     ||:..|   ||::|:..
  Fly  1001 REYTKLKDDS-----------AFKKTHEMLQKDLQSKLDVLER-----IQTPNMKALQKLDAVTE 1049

  Fly  1031 TFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEG------------DEMEKEV---ENSDAFTG-- 1078
            ..:...:.|....||.....|.|..:|.:.:..            |.:.|::   |.:.|:.|
  Fly  1050 KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD 1114

  Fly  1079 -------IGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMH 1136
                   .||..:........:.||.||||:|::.||||:||.....||||::.||||.|||..:
  Fly  1115 NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179

  Fly  1137 RKAVANMIHELSDTAQFITTTFRPELLENAHKFYGV 1172
            ...||:.|.:.:...|.|..:.:.|...:|....|:
  Fly  1180 IGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGI 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	317/1336 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	51/157 (32%)
		SMC_hinge	533..643	CDD:214944	32/120 (27%)
		TMPIT	678..>760	CDD:285135	16/87 (18%)
		CHD5	<780..>822	CDD:282299	4/44 (9%)
		P-loop_NTPase	<1088..1182	CDD:304359	32/85 (38%)
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	317/1336 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242	50/150 (33%)
		SMC_hinge	535..653	CDD:214944	45/181 (25%)
		DUF4700	<697..>810	CDD:292399	21/117 (18%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	32/86 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740