DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and smc1al

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_997975.2	Gene:	smc1al / 403060	ZFINID:	ZDB-GENE-040426-57	Length:	1233	Species:	Danio rerio

Alignment Length:	1320	Identity:	313/1320 - (23%)
Similarity:	563/1320 - (42%)	Gaps:	267/1320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLH 66
            ::|.|.|:.|||||.:.::.||.| ...::|.|||||||...||.|||:::.::||.:..:.|:|
Zfish     3 YLKLIEIENFKSYKGRQIIGPFHK-FTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIH 66

  Fly    67 EGTGARV-----ISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLE 126
               ||.|     ..|:|.:::.....      :|:...|:|.....:|.:|.|||..::....||
Zfish    67 ---GAPVGKPAANRAFVTMVYQQDGG------QELSFSRIIIGSSSEYRINNKVVGLSDYSEELE 122

  Fly   127 SAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT----RVYDERKEESLNLLRETDSKVE 187
            ..|.......::|.||.:..:|......|..|..|::.:    :.||..|:|.:....:|.....
Zfish   123 KLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDRCKKEMVKAEEDTQFNYH 187

  Fly   188 KISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDK 252
            :    .|.|....:..::||||.:.||     |...|.:|...:|:..|...:|.::::.:....
Zfish   188 R----KKNIAAERKEAKQEKEEAERYQ-----RLKDEVVRAHVQLQLFKLYHNESEIEKLNRELA 243

  Fly   253 KKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQ 317
            .:  |.||.|.::::..|::.||:.||       |...:|.:||.:.:|..:.|   .:||.:..
Zfish   244 HR--NKEIDKDRKRMDRVEEELKDKKK-------ELGRMMRDQQMIEKEIKEKD---AELNQKRP 296

  Fly   318 GDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAK---- 378
            ...|:||....::|.|:..    .|.|.:.:..|:..|...::..||....|..|:|...:
Zfish   297 LYIKAKENTAHKIKKLEAA----RKSLQNAQKCYKKRKGDMDELDREQGAVEMARQEFEERMEEE 357

  Fly   379 -QGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKK---DATSEKDL-----GQKI 434
             |.:|......|       |::|:..:...:.....|.|.::|:|   |..:::|.     .:||
Zfish   358 AQSQGQDLQLEE-------NQVKAYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKI 415

  Fly   435 EEHSSELEQLRLQIDEHNKKYYELKKTKD----QHQSMRNELWRKETQMTQQLQTHKEELSRADQ 495
            |..:...:::| :|:|:.|:   ::|.:|    ..||: :|..|.|.::|::::..|..:...:.
Zfish   416 ETEAKIKQKIR-EIEENQKR---IEKLEDYITTSRQSL-DEQKRMEEELTEEVEQAKRRIDEINM 475

  Fly   496 ALRSMAGKPILNGCDSVRKVLDSFVERGGQSAE---------IARAY----YGPVIENFSC---D 544
            .|..:           :.::.|:.::|...|.:         |.|.|    ||.:|:  .|   .
Zfish   476 ELNQV-----------MEQLGDARIDRQENSRQQRKAEILESIKRLYPGSVYGRLID--LCQPTQ 527

  Fly   545 KTIYTAVEVTAANRLFHHIVESEYEG---TQILKEMNKLKLPGE-VTFMPLNRLQVKIHDYPDDP 605
            |....||.......:...||:||..|   .|.:||..     || .||:||:.|:||    |.|.
Zfish   528 KKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQR-----GEPETFLPLDYLEVK----PTDE 583

  Fly   606 ------DSIPMISKLKYD-EQHDKALRYIFGKTLICRNLERATELA-------KSTGLDCVTLDG 656
                  .:..:|..::|: .|..|||:|..|..|:|.|:|.|..:|       |:     |.|||
Zfish   584 KLRELRGAKLVIDVIRYEPPQIKKALQYACGNALVCDNVEDARRIAFGGPYRHKT-----VALDG 643

  Fly   657 DQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKT 721
            ......|.::||     .|.|:.:.:|.:        ||.:.|    ||..:..:...:.|..|.
Zfish   644 TLFQKSGVISGG-----ASDLKAKARRWD--------EKAVDK----LKDRKEKLTDELKEQMKA 691

  Fly   722 ETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLA---QCKASLESMTSTKSSLEAELKQ 783
            :.|:.:.:.|..:..|....:|.....:||   .|.|.|:   |.|:.|||..:.......::|:
Zfish   692 KRKEAELRQVQSQAHGLQMRLKYSQSDLEQ---TKTRHLSLNMQEKSKLESELANFGPRINDIKR 753

  Fly   784 ELMSTLSSQDQREI-DQLN----------------DDIRRLNQE----NKEAFTQRMQFEVRKNK 827
            .:.|  ..:|.::: |::|                .:||...:|    ..|...:|::||.:|.:
Zfish   754 IIQS--RERDMKDLKDRMNVVEDEVFVEFCKEIGVRNIREFEEEKVKRQNEIAKKRLEFETQKTR 816

  Fly   828 LDNLL---INNLFRRRDELIQALQEIS-------------------VEDRKRKLNNCKTELVSAE 870
            |...|   .|.|...:::::...|.:.                   :::...:|.:.|.:.::.:
Zfish   817 LAIQLDYEKNQLKEDQEKVVMWEQTVKKDENEIEKLKKEEQRNMKIIDETMAQLQDLKNQHLTKK 881

  Fly   871 KRIKKVNSDLEEIEKRV----MEAVQLQKELQQELETHVRKEKEAEENLNKDSKQ---------- 921
            ..:...|.::|||.|::    .|..|||||: ..:||.:.:::....||.:..|.
Zfish   882 SEVNDKNHEMEEIRKKLGGANKELTQLQKEV-TAIETKLEQKRSDRHNLLQACKMQDIKLPLRSG 945

  Fly   922 -LEKWSTKENMLNEKIDE---CTEKIAS--LGAVPLVDPSYTRMS--LKN------IFKELEKAN 972
             ::..|.:|.  |.:.:|   .::|.:|  |....|::..|..:|  ||:      |..|:....
Zfish   946 TMDDISQEEG--NSQAEESLSSSQKTSSTVLAKEALIEIDYNSLSEDLKDSLSDEEIKAEMNTLQ 1008

  Fly   973 QHLKKYNHV-------NKKAL-------DQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQ 1023
            |.|.:...:       |.||:       |:|...|::.|...:|.       :|.....:.::.:
Zfish  1009 QRLNEQQSILQRISAPNMKAMEKLESVRDKFQETSDEFEAARKRA-------KKAKQAFEQIKKE 1066

  Fly  1024 KVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGV 1088
            :.:.....|..||.|..:::|.|....:....|..::.|...::            ||..:....
Zfish  1067 RFDRFHACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLD------------GINYNCVAP 1119

  Fly  1089 EAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS-DTAQ 1152
            ....|.|:.||||:|::.||||:|:|....||||::.||||.|||..:...|||.|.:.| ...|
Zfish  1120 GKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKDQSVQNFQ 1184

  Fly  1153 FITTTFRPELLENAHKFYGV 1172
            .|..:.:.|....|....||
Zfish  1185 AIVISLKEEFYTKADSLIGV 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	313/1320 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	49/160 (31%)
		SMC_hinge	533..643	CDD:214944	40/127 (31%)
		TMPIT	678..>760	CDD:285135	16/81 (20%)
		CHD5	<780..>822	CDD:282299	10/62 (16%)
		P-loop_NTPase	<1088..1182	CDD:304359	35/86 (41%)
smc1al	NP_997975.2	SMC_N	3..1209	CDD:280601	313/1320 (24%)
		ABC_SMC1_euk	4..>148	CDD:213242	48/153 (31%)
		SMC_hinge	513..628	CDD:214944	39/125 (31%)
		ABC_SMC1_euk	<1118..1221	CDD:213242	35/87 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810