DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and SMC2

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_610995.1 Gene:SMC2 / 36653 FlyBaseID:FBgn0027783 Length:1179 Species:Drosophila melanogaster


Alignment Length:1294 Identity:299/1294 - (23%)
Similarity:584/1294 - (45%) Gaps:226/1294 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            |::|::::.|||||..:|.:|.||.....:.|.|||||||...:|.|||. ....::|....|.|
  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNRVPID--------KEEIFLRRVIGAKKDQYFLNKKVVPRNEV 121
            :::...|.:..|.|.|:|||::   |..        :|....|:|:...|:::.:|.|:|...:|
  Fly    66 VYKNGQAGITKATVTIVFDNTN---PAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKV 127

  Fly   122 VNLLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKV 186
            .:...|...:.:||.:::.||||.|:........|.::.|.|||..|..:::.:..|:.:.::||
  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192

  Fly   187 EKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEY-IRYETELKDTKKALDELQLQRKSSS 250
            .:....|.  |:.|..|.:.::|...||::.|..|.::: ||.....|..|:......::.....
  Fly   193 RETKVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK 255

  Fly   251 DKKKIYNIEIQKAQE--KIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLN 313
            .:.:|.|.:...|:.  :::.::.::||.::::.: :...|:...|.|  |..|..|:.|.....
  Fly   256 IEDRIANCKATHAKNLAEVESIENSVKEMQQQIDA-EMGGSIKNLETQ--LSAKRALEATATGSL 317

  Fly   314 DEVQG----DNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKE-------EDCSRELQL 367
            ...||    |.|....|.:.:::.:..:|::|.::..|:.::|::|..:       ||..::|:.
  Fly   318 KAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEA 382

  Fly   368 KEQ-------------KRKELYAKQGRGSQFSSREDRDKWITNEL-----KSISKQ--------- 405
            ..|             :.:.:.||:    |||..:...|  |:|:     :.:.||         
  Fly   383 VSQGLSTNENGEASTLQEQLIVAKE----QFSEAQTTIK--TSEIELRHTRGVLKQREGETQTND 441

  Fly   406 ---TRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQS 467
               .:||..|. :||.::|   ..|:.| |.::......|:|:.:.::.:.:..:||:..|:..:
  Fly   442 AAYVKDKKLHD-QLVVEIK---NLERQL-QSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNA 501

  Fly   468 MRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARA 532
            .|.:|         |.|..:....|  :.:|.:.||..     .|:.:.:|.             
  Fly   502 SRYDL---------QYQDPEPNFDR--RKVRGLVGKLF-----QVKDMQNSM------------- 537

  Fly   533 YYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQV- 596
                             |:..||...|:.::.:.:....:||:..|   |...||.:|:|::|. 
  Fly   538 -----------------ALVQTAGGSLYSYVTDDDVTSKKILQRGN---LQRRVTLIPINKIQSG 582

  Fly   597 ----KIHDYPDDPDSIPMI----SKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLDC-- 651
                .:.:|..:......:    |.:.||..::..:::.||.||||::|..|.:::....::|  
  Fly   583 SLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRS 647

  Fly   652 VTLDGDQVSSKGSLTGGYFNTSRSRLE-------MQKKRTEYTSQIAEFEKKLSKLRNE---LKS 706
            |||:||.|...|:::||......:.||       ::|:..|..|:||:.||:::.:.|:   ...
  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNK 712

  Fly   707 TENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESM- 770
            .:.|::....|:...|.:..::  .|::.|.||..|:|.:..:||          |...|.|.. 
  Fly   713 MKENLDLRQHELTMCENRLAQT--TFQQNQAEIEEMRERVKTLEQ----------QIIDSREKQK 765

  Fly   771 TSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIR---------RLNQENKEAFTQRMQFEVRKN 826
            ||....::.|.|   ::......:||::...::|:         |.|.:.:|...:.:|.|:.:.
  Fly   766 TSQAKIVDIEAK---LADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITEL 827

  Fly   827 KLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCK-----TELVSAEKRIK-KVNSDLEEIEK 885
            :..   |....::..|:|..|::...|....|:|:..     |||..|.|..| |:....:|:..
  Fly   828 QKS---IETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRN 889

  Fly   886 RVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEK----------WSTKE----NMLNEKI 936
            ::::..::.|| .||:|..|:|::..::.::.|:|:.:|          |..:|    .|.|.:.
  Fly   890 QLVKKEKMLKE-NQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRY 953

  Fly   937 DECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYR 1001
            |...|           ||......|..:.::.:|..:.|      |..|:.......|..::..|
  Fly   954 DYSKE-----------DPHEAGNKLAKMQEKKDKMERTL------NMNAIMVLDREEENFKETER 1001

  Fly  1002 RKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEM 1066
            |:..:.:..:||..:|..::.::.:.:.....:|..||:.:|..|:| ||     :.|.|     
  Fly  1002 RRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLP-GA-----EAKLN----- 1055

  Fly  1067 EKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQA 1131
              .|..:...||:.|:|.|.|:..|  .:.:|||||||||||:|:.::.|..|||.|:.||:|.|
  Fly  1056 --PVHTNGCLTGLEIKVGFNGIWKE--SLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAA 1116

  Fly  1132 LDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAK 1190
            ||..|.:.:.:|:.:....:||:..:.:..|..:|:..:...|...||   .:||:.::
  Fly  1117 LDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVS---TITRQVSR 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 295/1281 (23%)
ABC_SMC3_euk 3..>159 CDD:213239 50/164 (30%)
SMC_hinge 533..643 CDD:214944 25/118 (21%)
TMPIT 678..>760 CDD:285135 20/91 (22%)
CHD5 <780..>822 CDD:282299 9/50 (18%)
P-loop_NTPase <1088..1182 CDD:304359 33/93 (35%)
SMC2NP_610995.1 Smc 1..1168 CDD:224117 297/1288 (23%)
ABC_SMC2_euk 1..>170 CDD:213240 52/171 (30%)
SMC_hinge 520..637 CDD:214944 30/154 (19%)
V_Alix_like 690..933 CDD:187408 57/261 (22%)
P-loop_NTPase <1073..1167 CDD:304359 34/98 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464472
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 90 1.000 Inparanoid score I342
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D11228at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.800

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