DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and Smc2

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001102136.2	Gene:	Smc2 / 362519	RGDID:	1305227	Length:	1191	Species:	Rattus norvegicus

Alignment Length:	1326	Identity:	327/1326 - (24%)
Similarity:	589/1326 - (44%)	Gaps:	289/1326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            |::|.||::|||||..:|.|..||...|.:.|.|||||||...:|.|:|. ...:.:|....|.|
  Rat     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNR-VPIDKE---EIFLRR--VIGAKKDQYFLNKKVVPRNEVVN 123
            :::...|.:..|.|.|.|||||.: .|:..|   ||.:.|  |||. :::|.:|........|.:
  Rat    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGG-RNKYLINGVNANNTRVQD 129

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            |..|.|.:.:||::::.||:|.::........|.::.|.||||:|:.:|..:...:.:.::|:::
  Rat   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKE 194

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLE-----YIRYETEL-KDTKKALDELQLQRK 247
            |...|:  |:...|:::.|||...|.::.|..|.:|     ||.|:..| :|||:         :
  Rat   195 IKTILE--EEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKE---------R 248

  Fly   248 SSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTK----LDLT 308
            |:.        |:::.|:||..:|:.|.|.:||:::       |..|.::|.:.|.|    :..:
  Rat   249 SAG--------ELKEMQDKILKLQEVLSENEKKIKA-------LNCEIEELEKRKDKETGGILRS 298

  Fly   309 IVDLNDEVQGDN-KSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKR 372
            :.|...|.|..| ||:...|.:.|||.....:| |||:         |...|| |:.|..||::.
  Rat   299 LEDAFAEAQRVNTKSQSAFDLKKKNLASEETKR-KELE---------KNMAED-SKALAAKEKEV 352

  Fly   373 KELYAKQG-RGSQFSSREDRD---------KWITNELKSISKQTRDKIAHHAKLVE-DLKKDATS 426
            |:|  ..| .|.|.:|.:|.:         ..::..|.|........:|......: |:.|..|.
  Rat   353 KKL--TDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTG 415

  Fly   427 EKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQ-QLQTHKEE- 489
            .|....|::....||:..:.::.:.:..|   ||.::..::::....:.||:|.: ..:.:|||
  Rat   416 AKQAQMKLKHAQQELKNKQAEVRKMDSGY---KKDQEAFEAVKKVKEKLETEMKKLNYEDNKEER 477

  Fly   490 -LSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIAR------AYYGPVIE-NFSC--- 543
             |.:..|..|.::..                  :|...|.:|:      ||..|... |.:|
  Rat   478 LLEKHRQVSRDISNL------------------KGTYEALLAKFPNLRFAYKDPEKNWNRNCVKG 524

  Fly   544 ---------DKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQ---- 595
                     |.:..||:|:.|..||::.:|::|..|.::|:   |.:|....|.:|||::.
  Rat   525 LVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLE---KGELKRRYTIIPLNKISARCI 586

  Fly   596 ----VKIHDYPDDPDSIPM-ISKLKYDEQHDKALRYIFGKTLICRNLERATELA--KSTGLDCVT 653
                :::......|:::.: :|.:.|..:..||:.::||.|.:|.|::.|.::|  |......||
  Rat   587 APETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVT 651

  Fly   654 LDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEM 718
            |.||.....|:|:||             .|::..|.:.:|:        |||..:..:.:...|:
  Rat   652 LGGDVFDPHGTLSGG-------------ARSQAASILTKFQ--------ELKDVQAELRTKEKEL 695

  Fly   719 QKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQ 783
            |..|.:....|:|.||                 ||        |.|...|..|.....|:.:|:|
  Rat   696 QALEEELAGLKNVAEK-----------------YR--------QLKQQWEMKTEEGDLLQTKLQQ 735

  Fly   784 ELMSTLSSQDQREIDQLNDDIRRLNQENKEAF--TQRMQ------FEVRKNKLDNLLINNLFRRR 840
               |:...| |.|:|.|...|    :|::|..  |:.:|      :|..:||:.|
  Rat   736 ---SSYHKQ-QEELDALKKTI----EESEETLKNTKEIQKKAEEKYEALENKMKN---------- 782

  Fly   841 DELIQALQEISVEDRKRKLNNCKTELVSAEKRIKK-------VNSDLEEIEKR----------VM 888
               .:|.:|..::|.::||:..||:..::.|::|:       :..:|||:::.          |.
  Rat   783 ---AEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVN 844

  Fly   889 EAVQL--------------QKELQQELETHVRKEKE---AEENLNKDS-KQLEKWSTKENMLNEK 935
            ||::.              .||...:.:..:.|:||   |::|:.||. .::.|.:.:.|....|
  Rat   845 EAIKAYEGQIEIMAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEVAKHNLQNNDSQLK 909

  Fly   936 I--------------DECTEKIASLGAVPLVDPSYTRMSLKNIF-----------KELEKANQHL 975
            |              |:...|::.:    |.|..:.... |::|           ...::|.|.|
  Rat   910 IKELDHSISKHKREADDAAAKVSKM----LNDYDWINAE-KHLFGQPNSAYDFKTNNPKEAGQRL 969

  Fly   976 KKY--------NHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTF 1032
            :|.        .:||.:|::......|:...|.::|..::....||...|:.|:.:|.:|:...:
  Rat   970 QKLQEVKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAW 1034

  Fly  1033 RQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQ 1097
            ::|.::|..:|..|:| ||..::...            |......|:..:|:......|  .:.:
  Rat  1035 QKVNKDFGSIFSTLLP-GANAMLAPP------------EGQTVLDGLEFKVALGNTWKE--NLTE 1084

  Fly  1098 LSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPEL 1162
            |||||:|||||:||.|:....|||.|:.||:|.|||..|.:.:..|:......:|||..:.:..:
  Rat  1085 LSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGM 1149

  Fly  1163 LENAHKFYGVRFRNKVSHIDCVTREE 1188
            ..||:..:..:|.:.||.:...|:.:
  Rat  1150 FNNANVLFKTKFVDGVSTVARFTQSQ 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	324/1315 (25%)
		ABC_SMC3_euk	3..>159	CDD:213239	56/162 (35%)
		SMC_hinge	533..643	CDD:214944	32/131 (24%)
		TMPIT	678..>760	CDD:285135	15/81 (19%)
		CHD5	<780..>822	CDD:282299	13/49 (27%)
		P-loop_NTPase	<1088..1182	CDD:304359	34/93 (37%)
Smc2	NP_001102136.2	Smc	1..1168	CDD:224117	326/1317 (25%)
		ABC_SMC2_euk	1..>172	CDD:213240	60/171 (35%)
		L_lactis_ph-MCP	252..>465	CDD:115336	57/235 (24%)
		SMC_hinge	522..639	CDD:214944	28/119 (24%)
		PCRF	693..>761	CDD:305100	25/100 (25%)
		DUF4200	740..841	CDD:290574	26/118 (22%)
		P-loop_NTPase	<1074..1168	CDD:304359	34/95 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820