Protein Alignment SMC3 and Smc2

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001102136.2
• Gene: Smc2 / 362519
• RGDID: 1305227
• Length: 1191
• Species: Rattus norvegicus
• Alignment Length: 1326
• Identity: 327/1326 - (24%)
• Similarity: 589/1326 - (44%)
• Gaps: 289/1326 - (21%)

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            |::|.||::|||||..:|.|..||...|.:.|.|||||||...:|.|:|. ...:.:|....|.|
  Rat     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNR-VPIDKE---EIFLRR--VIGAKKDQYFLNKKVVPRNEVVN 123
            :::...|.:..|.|.|.|||||.: .|:..|   ||.:.|  |||. :::|.:|........|.:
  Rat    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGG-RNKYLINGVNANNTRVQD 129

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            |..|.|.:.:||::::.||:|.::........|.::.|.||||:|:.:|..:...:.:.::|:::
  Rat   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKE 194

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLE-----YIRYETEL-KDTKKALDELQLQRK 247
            |...|:  |:...|:::.|||...|.::.|..|.:|     ||.|:..| :|||:         :
  Rat   195 IKTILE--EEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKE---------R 248

  Fly   248 SSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTK----LDLT 308
            |:.        |:::.|:||..:|:.|.|.:||:::       |..|.::|.:.|.|    :..:
  Rat   249 SAG--------ELKEMQDKILKLQEVLSENEKKIKA-------LNCEIEELEKRKDKETGGILRS 298

  Fly   309 IVDLNDEVQGDN-KSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKR 372
            :.|...|.|..| ||:...|.:.|||.....:| |||:         |...|| |:.|..||::.
  Rat   299 LEDAFAEAQRVNTKSQSAFDLKKKNLASEETKR-KELE---------KNMAED-SKALAAKEKEV 352

  Fly   373 KELYAKQG-RGSQFSSREDRD---------KWITNELKSISKQTRDKIAHHAKLVE-DLKKDATS 426
            |:|  ..| .|.|.:|.:|.:         ..::..|.|........:|......: |:.|..|.
  Rat   353 KKL--TDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTG 415

  Fly   427 EKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQ-QLQTHKEE- 489
            .|....|::....||:..:.::.:.:..|   ||.::..::::....:.||:|.: ..:.:|||
  Rat   416 AKQAQMKLKHAQQELKNKQAEVRKMDSGY---KKDQEAFEAVKKVKEKLETEMKKLNYEDNKEER 477

  Fly   490 -LSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIAR------AYYGPVIE-NFSC--- 543
             |.:..|..|.::..                  :|...|.:|:      ||..|... |.:|
  Rat   478 LLEKHRQVSRDISNL------------------KGTYEALLAKFPNLRFAYKDPEKNWNRNCVKG 524

  Fly   544 ---------DKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQ---- 595
                     |.:..||:|:.|..||::.:|::|..|.::|:   |.:|....|.:|||::.
  Rat   525 LVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLE---KGELKRRYTIIPLNKISARCI 586

  Fly   596 ----VKIHDYPDDPDSIPM-ISKLKYDEQHDKALRYIFGKTLICRNLERATELA--KSTGLDCVT 653
                :::......|:::.: :|.:.|..:..||:.::||.|.:|.|::.|.::|  |......||
  Rat   587 APETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVT 651

  Fly   654 LDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEM 718
            |.||.....|:|:||             .|::..|.:.:|:        |||..:..:.:...|:
  Rat   652 LGGDVFDPHGTLSGG-------------ARSQAASILTKFQ--------ELKDVQAELRTKEKEL 695

  Fly   719 QKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQ 783
            |..|.:....|:|.||                 ||        |.|...|..|.....|:.:|:|
  Rat   696 QALEEELAGLKNVAEK-----------------YR--------QLKQQWEMKTEEGDLLQTKLQQ 735

  Fly   784 ELMSTLSSQDQREIDQLNDDIRRLNQENKEAF--TQRMQ------FEVRKNKLDNLLINNLFRRR 840
               |:...| |.|:|.|...|    :|::|..  |:.:|      :|..:||:.|
  Rat   736 ---SSYHKQ-QEELDALKKTI----EESEETLKNTKEIQKKAEEKYEALENKMKN---------- 782

  Fly   841 DELIQALQEISVEDRKRKLNNCKTELVSAEKRIKK-------VNSDLEEIEKR----------VM 888
               .:|.:|..::|.::||:..||:..::.|::|:       :..:|||:::.          |.
  Rat   783 ---AEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVN 844

  Fly   889 EAVQL--------------QKELQQELETHVRKEKE---AEENLNKDS-KQLEKWSTKENMLNEK 935
            ||::.              .||...:.:..:.|:||   |::|:.||. .::.|.:.:.|....|
  Rat   845 EAIKAYEGQIEIMAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEVAKHNLQNNDSQLK 909

  Fly   936 I--------------DECTEKIASLGAVPLVDPSYTRMSLKNIF-----------KELEKANQHL 975
            |              |:...|::.:    |.|..:.... |::|           ...::|.|.|
  Rat   910 IKELDHSISKHKREADDAAAKVSKM----LNDYDWINAE-KHLFGQPNSAYDFKTNNPKEAGQRL 969

  Fly   976 KKY--------NHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTF 1032
            :|.        .:||.:|::......|:...|.::|..::....||...|:.|:.:|.:|:...:
  Rat   970 QKLQEVKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAW 1034

  Fly  1033 RQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQ 1097
            ::|.::|..:|..|:| ||..::...            |......|:..:|:......|  .:.:
  Rat  1035 QKVNKDFGSIFSTLLP-GANAMLAPP------------EGQTVLDGLEFKVALGNTWKE--NLTE 1084

  Fly  1098 LSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPEL 1162
            |||||:|||||:||.|:....|||.|:.||:|.|||..|.:.:..|:......:|||..:.:..:
  Rat  1085 LSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGM 1149

  Fly  1163 LENAHKFYGVRFRNKVSHIDCVTREE 1188
            ..||:..:..:|.:.||.:...|:.:
  Rat  1150 FNNANVLFKTKFVDGVSTVARFTQSQ 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	324/1315 (25%)
Smc2	NP_001102136.2	SMC_N	2..1167	CDD:426784	324/1315 (25%)