DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMC3 and glu

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_723996.1 Gene:glu / 35001 FlyBaseID:FBgn0015391 Length:1409 Species:Drosophila melanogaster


Alignment Length:1303 Identity:302/1303 - (23%)
Similarity:578/1303 - (44%) Gaps:227/1303 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |.:|:.:.||||..:..:.||.:....::|.|||||||...::.||.......:|.::..:|:|.
  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHS 153

  Fly    68 GTG-----ARVISAYVEIIFDNSDNR---VPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNL 124
            .:.     :..::.:.:.|.|..|..   || |...:..|..:......|.:|.|.....:|..|
  Fly   154 SSSYPNLRSCSVAVHFKQIVDKGDGTCEDVP-DSSIVIERTAMSDNSSYYQINDKRAQLKDVAKL 217

  Fly   125 LESAGFSSSNPYYIVKQGKINQMA-------TAADSYRLKLLREVAGTRVYDERKEESLNLLRET 182
            |:.......:..:::.||::..:|       |..::..|:.|.::.||:.|       :..|::.
  Fly   218 LKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRY-------IRPLQQI 275

  Fly   183 DSKVEKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRK 247
            :.:|:::::......:|.:..|.|.::|::     .....::|::.|.||..||    ...:|:.
  Fly   276 NQRVDQLTDDRTEKHNRCKLAEREMKDLEQ-----PFNEAVDYLKKENELVRTK----SFHIQKI 331

  Fly   248 SSSDKKKI--YNIEIQKAQEKIKDVQKN---LKEAKKK----VQSTKEERSVLMTEQQQLLREKT 303
            .|..|.|:  |..|.:...|::|...:.   ||:::.:    ::...||...|:.:::|:   |.
  Fly   332 ISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQI---KK 393

  Fly   304 KLDLTIVDLNDEVQG--DNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQ 366
            :| :|:.....|:|.  :|.:|:|     |..|..|.:.||||:|:....|..:|:.|||:::|:
  Fly   394 RL-VTVESAYTEIQSTMENTNKQR-----KKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLE 452

  Fly   367 LKEQKR----KELYAKQGRGSQFSS--REDRDKWITNELKSISKQ---TRDKIAHHAKLVEDLKK 422
            ..|..:    :||..:|...::.::  .|.|.| :::||..:.::   .:.::......::.||:
  Fly   453 SLEVSKVTLNEELEKQQAELTKTTAPLTEKRLK-LSDELVGLKEKVNTAKGEVQVFESQLKILKQ 516

  Fly   423 DATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELK------KTKDQHQSMR-NELWRKETQMT 480
            ..|:|   .:|.|...|..||.:..::|...:..|||      ||:...:|.. :::.::|..::
  Fly   517 AETTE---SRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLS 578

  Fly   481 QQ---LQTHKEELSRADQALRS------------MAGKPILNGCDSVRKVLDSFVERGGQSAEIA 530
            .|   |:|...|.|...||.||            |.||        :..:|....:.||..|:  
  Fly   579 MQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGK--------IPGILGRLGDLGGIDAK-- 633

  Fly   531 RAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQ----ILKEMNKLKLPGEVTFMPL 591
                             |.....||..|| .:||...||...    .|||.|    .|..||:.|
  Fly   634 -----------------YDIAISTACGRL-DNIVTDNYETASAAIGALKEYN----VGRATFITL 676

  Fly   592 NRLQ---VKIHDYPDDPDSIPMISKL--KYDEQHDKALRYIFGKTLICRNLERATELAKSTGLD- 650
            ::::   .:.:...:.|:::|.:..|  ..|::...|..:....||:|.:||:.|.:|  .|.: 
  Fly   677 DKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIA--YGRER 739

  Fly   651 --CVTLDGDQVSSKGSLTGGYFNTSRSRL--EMQKKRTEY--TSQIAEFEKKLSKLRNELKSTEN 709
              .|||.|:.:...|:::||.....|.::  :::.|..|.  :|||:  :|.|..::.:.:..:.
  Fly   740 YRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESADSSQIS--QKALEDMQIQAEELQA 802

  Fly   710 NINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTK 774
            .:|....:....|.:....|:..::.:.|.:.:...:..:||..|   .:|.||:|..:.|    
  Fly   803 RVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMA---SNLKQCEAQRQRM---- 860

  Fly   775 SSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEA-FTQR---MQFEVRKNKLDNL---- 831
                  ||:       :.|:|.:.:..:.|....||.::| |.::   .|.|..:|:.|.|    
  Fly   861 ------LKK-------TTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRNES 912

  Fly   832 ---------LINNLFRRRDELIQALQ-EISVEDRK-RKL----NNCKTELVSAEKRIKKVNSDLE 881
                     .:|:...:....:::|. .::..||. .|:    ||.:..:.:||:::|.:|.|..
  Fly   913 VKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRN 977

  Fly   882 EIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASL 946
            :.:::..|   |:||: :|.|..:...|....::.|:..::.|...|.|:  |:|:..|:..|:.
  Fly   978 KAKEKKEE---LEKEI-EESEASIEGAKSQSSDIKKEIDEITKEENKRNI--ERIEIDTKLQAAA 1036

  Fly   947 GA-------VPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALD-QFLSFSEQ--KEKLYR 1001
            |.       :|........:.|..|..|.| ....||:.|....:|.. :.|.:.:.  :|.|..
  Fly  1037 GKMNKVKNDIPGWQAQLAPLKLNEIPGETE-PQAPLKELNEEELEAETLEALQYKQTMLEEDLKT 1100

  Fly  1002 RKEEL----DIGDQKIHML--IQSLE--MQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKT 1058
            :|..|    :..::::..|  ::.||  ..|...::..:.:|.:...|.|..      ||.|:..
  Fly  1101 KKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMD------GFSIITR 1159

  Fly  1059 KDNE-------GDEMEKE-VENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQ 1115
            |..|       |.:.|.| |::.|.||. |:..:....:...:.::.||||:|:|.:|||:|::.
  Fly  1160 KLKEMYQMITLGGDAELELVDSMDPFTE-GVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALH 1223

  Fly  1116 KCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSH 1180
            ...|:|.|..||||.|||..:...|.:.|.|.:..||||..:.|..:.|.|:...|:   .||| 
  Fly  1224 YYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVGI---YKVS- 1284

  Fly  1181 IDC 1183
             ||
  Fly  1285 -DC 1286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 299/1298 (23%)
ABC_SMC3_euk 3..>159 CDD:213239 39/170 (23%)
SMC_hinge 533..643 CDD:214944 28/118 (24%)
TMPIT 678..>760 CDD:285135 14/83 (17%)
CHD5 <780..>822 CDD:282299 10/45 (22%)
P-loop_NTPase <1088..1182 CDD:304359 34/93 (37%)
gluNP_723996.1 ABC_SMC4_euk 87..>246 CDD:213241 37/157 (24%)
Smc 89..1281 CDD:224117 297/1294 (23%)
SMC_hinge 618..733 CDD:214944 32/138 (23%)
ATP-synt_B <825..904 CDD:304375 20/98 (20%)
ABC_SMC4_euk <1196..1290 CDD:213241 36/96 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464468
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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