Protein Alignment SMC3 and LOC3291777

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: XP_557814.3
• Gene: LOC3291777 / 3291777
• VectorBaseID: AGAMI1_014685
• Length: 1213
• Species: Anopheles gambiae
• Alignment Length: 1233
• Identity: 448/1233 - (36%)
• Similarity: 694/1233 - (56%)
• Gaps: 63/1233 - (5%)

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |::|:|||.||||||.|||||..|.:||||||||||||||||.||:||||||:.:|||.||..|:
Mosquito     1 MYLKEIIINGFKSYKLQTVVERLDPKHNVVVGRNGSGKSNFFSAIEFVLSDEYNNLRPAQRVGLI 65

  Fly    66 HEGTGA-RVISAYVEIIFDNS--DNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLES 127
            ::||.. |..||||||:||:|  ....|....|..:||.|.|.||||.:|.:...|.|:..||::
Mosquito    66 NKGTSKNRSDSAYVEIVFDHSSASQTTPSPGTETRIRRTISATKDQYTVNGRNATRKEIDELLDT 130

  Fly   128 AGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEY 192
            .|.||.||||||||||::|:.||.....|:||.::.|.|||||:.:|.|.|.::.|..:::|...
Mosquito   131 LGLSSCNPYYIVKQGKVSQLTTARPRQLLQLLYDIGGIRVYDEKLKEILKLWQDADKGLQQIHAE 195

  Fly   193 LKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYN 257
            ...:.:||:.|..::.|.:.:::.:|..|.|:.:..:   |..:..|..|:...::..:.|
Mosquito   196 RTALANRLELLSSQQREQRAFEQLEKKHRVLQSVVLD---KKQQCVLAALEAHGQAGQEWK---- 253

  Fly   258 IEIQKA--QEKIKDVQKN--LKEAKKKVQSTKEERSVL----MTEQQQLLREKTKLDLTIVDLND 314
             |.|:|  ::|.:.|.::  ||:|:|..:|.......|    .||..:|.|.||::||.:.||..
Mosquito   254 -EKQRALLEQKTEAVNRSKVLKQAQKDNESELASAEALKADQATEALRLDRHKTRVDLKMDDLQK 317

  Fly   315 EVQG----DNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKEL 375
            |::.    .|..:|:.:::.:.    |||.:.:|..:..::..::.:......::.:|:|.|.|.
Mosquito   318 ELRRLLGLQNSEQEQLEKDNEE----IAELQAKLQTLSREWAKVQEQRAALDFDVLMKKQLRSER 378

  Fly   376 YAKQGRGSQFSSREDRDKWITNELKSISKQTRD---KIAHHAKLVEDLKKDATSEKDLGQKIEEH 437
            ..|..||.||::||:||:::..|:....||...   .:|...:..|.|.|:..|||   ...|..
Mosquito   379 LNKLRRGEQFATREERDRFLQQEIAYAGKQIESDSKALAEAKRARETLAKELASEK---ASHERD 440

  Fly   438 SSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAG 502
            .:||.:|..|...:..:..::.:...:.:.:.::|...|...|.:|...|..::|.:|.||...|
Mosquito   441 EAELRELTEQEQHYASQLAQISERLREAKGVLDDLLANEAAQTLELNDCKALIARQEQMLRKKLG 505

  Fly   503 KPILNGCDSVRKVLDSFVERGGQS--AEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVE 565
            .....||.|||.||::...:|...  ||:|:.|.|.|::.|.||||||.|||..|.|:||:|:||
Mosquito   506 PATYQGCKSVRTVLEALCAQGNDDGRAEVAQGYCGRVLDLFHCDKTIYQAVETVAGNKLFYHVVE 570

  Fly   566 SEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSI-PMISKLKYDEQHDKALRYIFG 629
            |:...::|:....:.|||||..|||||||......||.|..|: |:||.|.||..::...|:|||
Mosquito   571 SDRIASEIIALCTRHKLPGEYNFMPLNRLHASKQKYPPDSASVRPLISLLTYDGCYEPVFRHIFG 635

  Fly   630 KTLICRNLERATELAKSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFE 694
            |||:|..||.|..:|:..||.|||.:||.| ..|.|:|||.:.:.|.::.:       ..:::.:
Mosquito   636 KTLLCEELETAARVAQQYGLCCVTHEGDTV-RPGVLSGGYRSPTASTIQAR-------LLLSDLD 692

  Fly   695 KKLSKLRNELKSTENNINSIV-----SEMQKTE--TKQGKSKDVFEKVQGEIRLMKEELVRIEQY 752
            .|:|:|.:.||:|..:|....     ||::.|.  .|..::|...|.|:..||...|...::|..
Mosquito   693 DKMSQLEDSLKTTVESIPPAARLIKGSELEHTNEARKLERAKQHVESVRERIRAFPERCRKLEAK 757

  Fly   753 RAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQ 817
            .:.....:...:..|:.:.:....|..|...:....||.:|.|.|:||:..||.:.:...|||..
Mosquito   758 LSEAGSKIRALETELQLVRAKVDGLRREFATKFDCVLSEEDVRVIEQLDAAIREIERRKHEAFNA 822

  Fly   818 RMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEE 882
            ::|.|..|.|::|.|...|..|||.|:.:.......:.|..:..||.|..:...:|..:...::|
Mosquito   823 QLQAEQAKAKIENRLNTVLLPRRDALVASGGGARCRELKELILQCKREQDAFTLKIDNLQKKMKE 887

  Fly   883 IEKRVMEAVQLQKELQQELETHVRKEKEAEENLN-KDSKQLEKWSTKENMLNEKIDECTEKIASL 946
            .|:.:::|.:.:.:|..||:....|.|..||.|: .|.:|:...:.|.::.|| ..:..|:|.:|
Mosquito   888 NEQLILKATERRNKLAAELDRWSEKLKTTEEALSIGDPQQMRHEARKRDLENE-ARQYAEQIGAL 951

  Fly   947 GAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQ 1011
            |.:|.:|.:|.||.|..:.|||::.::.|||:..||:.|.|:....|::...:.|:.::|:....
Mosquito   952 GVLPAIDRAYQRMELPTLMKELDRTSKQLKKFGSVNQAATDESTRLSQELSSIDRKLQQLEQSRA 1016

  Fly  1012 KIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENS--- 1073
            .....||.|..|:.::::.||..|.:||.::|.||||.|.|.|.|:|.|.: :..|..:|.:
Mosquito  1017 LHDASIQQLRAQRTDSLERTFDSVRRNFGEIFSKLVPAGCGQLSLQTADLD-EAAEGAIERTDHP 1080

  Fly  1074 ------DAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQAL 1132
                  |.:.|:.:.|||.|....|||||.||||||:|||:||||:||:..||||||||||||||
Mosquito  1081 DGGEPVDRYVGLRLEVSFRGNGELMREMNALSGGQKTLVAIALIFAIQRNKPAPFYLFDEIDQAL 1145

  Fly  1133 DAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVED 1195
            ||.|||.:|..|..||.::||||.|||.||||:|.|::|||:||.:|.||.||:::|.||:.|
Mosquito  1146 DAQHRKVIAGEIAALSASSQFITITFRRELLEHAAKYFGVRYRNNMSFIDPVTKQQAYDFIVD 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	438/1215 (36%)
LOC3291777	XP_557814.3	None