Protein Alignment SMC3 and SMC5

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1280
• Identity: 257/1280 - (20%)
• Similarity: 477/1280 - (37%)
• Gaps: 370/1280 - (28%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRH--NVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |..:..:.|.||.:.|    |..:|  ||:.|.||||||....||...|..|...|   .|.:.:
  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILL---DRSASV 73

  Fly    66 HEGTGARVISAYVEI-IFDNSDNRVPIDKEEIFLRRVIGAK-KDQYFLNKKVVPRNEVVNLLESA 128
            .:...:...||.:.: ::..:.|..     |.| ||:|.:. ...:.:|.|...:...:..:.|.
  Fly    74 ADYIQSNKTSATIIVRVYGRTPNTT-----ETF-RRIINSNGLSTFSVNDKDTSKKNFLAAVSSF 132

  Fly   129 GFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYL 193
            ....||....:.|.::...:.....   :||.....: |.||....|.|.|::  .:.|:.:.:.
  Fly   133 NIQVSNLCQFLPQDRVQDFSKMNPQ---ELLLNTMSS-VCDEDLINSFNSLKQ--MRTEQANVHA 191

  Fly   194 KTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYE-TELKDTKKALDELQLQRKSSSDKKKIYN 257
            ..        |:||.:|.:.||      .||:::.. ::.|:.::...:||:.     ..||::
  Fly   192 NR--------EKEKSDLVKKQK------RLEHLQMTVSQYKEREEVKQKLQVY-----SAKKLW- 236

  Fly   258 IEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKS 322
            :|.|..:.|..:::..:|.||.:....|.:...|:..|:|:.:||..|...:::....::.....
  Fly   237 VETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAE 301

  Fly   323 KERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSS 387
            |...|.::.:||..|.:::.||:.   ..:..:|...:|....||.|.|   :|
  Fly   302 KAAIDGKMDSLKQGIYQKKYELEQ---NIKKSRRTATECDNLNQLVENK---IY----------- 349

  Fly   388 REDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHN 452
                      ||::::| :|..|...   :|..|:...:.:  |:.:|::|.     |.|:::
  Fly   350 ----------ELETLNK-SRPLIVSE---LERAKESCAAAR--GKAMEQYSR-----RRQLEQ-- 391

  Fly   453 KKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLD 517
                   |..|              :|..::..:|.::.|    ||::..:.|    |.:|....
  Fly   392 -------KLND--------------EMIPEITAYKLKIER----LRNVKMQKI----DEIRAKNP 427

  Fly   518 SFVERGGQSAEIARAY----YGPVI-----ENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQI 573
            :.|......|:..:.|    |.|:|     :|....|.:   ..|.|...||....|.:.:.:.:
  Fly   428 NLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFL---ENVVAQRDLFAFACEDKGDMSDL 489

  Fly   574 LKEM-NKLKLPGEVTF-MPLNRLQVKIHDYPDDPDS--------------IPMISKL-------- 614
            :.|: .|.||...|.: .|.:||........||..|              ||:|:||
  Fly   490 INELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHN 554

  Fly   615 ---------KYDEQHDKALRYIFG---KTLICRNLERATELAKSTGL----DCVTLDGDQ----- 658
                     .|.....||:|..||   |.::..:..|:..:...:.:    ..:|:|..|
  Fly   555 IPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVM 619

  Fly   659 ------VSSKGSLTGGYFNTSR--SRLEM-----QKKRTEYTSQIAEF----------EKKLSKL 700
                  |....|:......|..  .||:.     |:||.:...:||.|          :|||..|
  Fly   620 KQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEAL 684

  Fly   701 RN--ELKSTENNI-NSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQ 762
            ||  .|...|.|. ||:..:::|          :|:                      .:..|..
  Fly   685 RNSDSLDCLETNFCNSLHKDLKK----------IFD----------------------ADAELCS 717

  Fly   763 CKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNK 827
            |..:::.:.     :|..:.|..:|....|.:.:|:.|.:     ::|..:|.|:..|
  Fly   718 CLKAIDRLI-----IEKNMAQTKVSIYMLQHETQIEALKE-----SEEQSKAATRDFQ------- 765

  Fly   828 LDNLLINNLFRRRDELIQALQ-EIS-VEDRKRKLNN-CKTELVSAEK-RIKKVNSDLEEIE-KRV 887
                          :|:|.|: :|| |..||..:.. |..|:.::.| ..||...:||.|: ..:
  Fly   766 --------------QLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPEL 816

  Fly   888 MEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPLV 952
            .||:.   :.|..|                                    ||.:.:.|...
  Fly   817 REAIH---DFQARL------------------------------------ECMKSVNSEAI---- 838

  Fly   953 DPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLI 1017
             .||  ..|:|..|:||:..|          ::::|..|.......||      |..:.|::.|:
  Fly   839 -SSY--QGLQNEVKQLEEGIQ----------ESVNQAKSIESGMSNLY------DKWEPKLNSLV 884

  Fly  1018 QSLE---MQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGI 1079
            :::.   .:.:|:|::                    .|.::|...|.         .:.|:: ||
  Fly   885 ETISTKFSEFMESIEY--------------------VGEVVLSKTDK---------YDFDSY-GI 919

  Fly  1080 GIRVSF-TGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANM 1143
            .|.|.| .|::.:..:....|||::::.......|:|.....||...|||:|.:||.:.:.:.::
  Fly   920 QIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDL 984

  Fly  1144 IHELS---DTAQFITTTFRPELLE----NAHKFYGVRFRNK-VSH 1180
            :.:.:   .:||::..|  |:||.    |.|....:...:| |.|
  Fly   985 LLKEATKHGSAQYLFVT--PKLLRDLNYNEHLCVSIVHNSKTVCH 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	256/1278 (20%)
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	36/159 (23%)
		SMC_N	22..>425	CDD:481474	106/510 (21%)
		SMC_prok_B	<193..1001	CDD:274008	203/1054 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	27/107 (25%)