DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and smc3

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_999854.1	Gene:	smc3 / 324475	ZFINID:	ZDB-GENE-030131-3196	Length:	1216	Species:	Danio rerio

Alignment Length:	1219	Identity:	643/1219 - (52%)
Similarity:	886/1219 - (72%)	Gaps:	24/1219 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |:|||:|||||:||:|||||:||..:|||:|||||||||||||||||||||||:|||||||.:||
Zfish     1 MYIKQVIIQGFRSYRDQTVVDPFGSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALL 65

  Fly    66 HEGTGARVISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGF 130
            |||||.|||||:|||||||||||:||||||:.||||||||||||||:||:|.:|:|:||||||||
Zfish    66 HEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGF 130

  Fly   131 SSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLKT 195
            |.||||||||||||||||||.||.|||||||||||||||||||||::|::||:.|.|||:|.||.
Zfish   131 SRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKY 195

  Fly   196 IEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIEI 260
            ||:||.|||:|||||.:||||||.||.|||..|..||.:|:..||||..:|::..||.:......
Zfish   196 IEERLHTLEDEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSSKRETCGDKSRQLRDAQ 260

  Fly   261 QKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKER 325
            |.|::|:::.::.::|.|.::.:.|||:..|..|:|:.::::|||:|...||.||:.|:::.::|
Zfish   261 QDARDKVEETERVVRELKSRISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325

  Fly   326 ADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSRED 390
            ..:|.:.|...|.|::|||.:.:||:..:|.|||.....|....|:|.:|||||||||||:|:|:
Zfish   326 LLKERQKLLEKIEEKQKELQETEPKFNTVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEE 390

  Fly   391 RDKWITNELKSISKQTRDKIAHHAKLVEDLK-KDATSEKDLGQ--KIEEHSSELEQLRLQIDEHN 452
            |||||..||||:.:...||....|.:.:||: .:...|::|.|  |:::   :|.:::.:::|.:
Zfish   391 RDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEQNKERNLEQYNKLDQ---DLNEVKTRVEELD 452

  Fly   453 KKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLD 517
            |||||:|..||:.||.||.|||:|....|.|...:|:|.:..|.||:..||.||||.||:.|||:
Zfish   453 KKYYEVKNRKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLE 517

  Fly   518 SFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKL 582
            .| .|.|.:..:...|:|.|:.||.|:...||.|||||..|||:||||::...|:||.|.||:.|
Zfish   518 HF-RRKGINQHVINGYHGIVMNNFECEPAFYTCVEVTAGTRLFYHIVETDEVSTKILMEFNKMNL 581

  Fly   583 PGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATELAKST 647
            ||||||:||::|.|:...||:..|:|||||||:|.:..|||.:::||||||||::|.:|:||::.
Zfish   582 PGEVTFLPLSKLDVRDTAYPETNDAIPMISKLRYSQNFDKAFKHVFGKTLICRSMEVSTQLARAF 646

  Fly   648 GLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSK-LRNELKSTENNI 711
            .:||:||:|||||.:|:|||||::|.:||||:||...:...::.|.|.||:: ||..:::..|.|
Zfish   647 TMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDMRKAEEELGELEAKLNENLRRNIETINNEI 711

  Fly   712 NSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSS 776
            :.::::||:.||:|.|.|...:.:..|::::||:..:.|:...||:|||...:|||.:|.||:.|
Zfish   712 DQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRES 776

  Fly   777 LEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRD 841
            |:|||..:|:|.||.:|||.:|.|||:||:|.|:|::...:|::.|....:::..|..||.:|.|
Zfish   777 LKAELGADLLSQLSLEDQRRVDDLNDEIRQLQQDNRQLLNERIKLEGIMTRVETYLNENLRKRLD 841

  Fly   842 ELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVR 906
            ::.|.|.|:...:....|....:||....||||...:..|:::..:.:.....||.|:.:|....
Zfish   842 QVEQELNELRETEGGTVLTATTSELDGINKRIKDTMARSEDLDTLIDKTEVEIKEHQKSMERWKN 906

  Fly   907 KEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPL-VDPSYTRMSLKNIFKELEK 970
            .|||..|.:|.|:|:|||.:.::.||.:|.:||.:||..||::|. ....|..::||.:|::||:
Zfish   907 IEKEQNEAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLTLKQLFRKLEQ 971

  Fly   971 ANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQV 1035
            .|..||||:||||||||||::||||||||.:|::|||.|.:.|..|:..||::|.||||.||:||
Zfish   972 CNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQDELDRGYKSIMELMNVLELRKYEAIQLTFKQV 1036

  Fly  1036 AQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDA---------------FTGIGIRVSF 1085
            ::||::||:||||.|...|::|..|.||.:.:.|.|..|:               |||:||||||
Zfish  1037 SKNFSEVFQKLVPGGKATLVMKKGDTEGGQSQDEGEGGDSERASSSQSSVPSVDQFTGVGIRVSF 1101

  Fly  1086 TGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDT 1150
            ||.:.|||||.||||||||||||||||:|||||||||||||||||||||.||||.::||.||:..
Zfish  1102 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAASDMIMELAGH 1166

  Fly  1151 AQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVEDDSTH 1199
            ||||||||||||||:|.|||||:|||||||||.::.|:||||||||:||
Zfish  1167 AQFITTTFRPELLESADKFYGVKFRNKVSHIDVISAEQAKDFVEDDTTH 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	627/1197 (52%)
		ABC_SMC3_euk	3..>159	CDD:213239	130/155 (84%)
		SMC_hinge	533..643	CDD:214944	61/109 (56%)
		TMPIT	678..>760	CDD:285135	25/82 (30%)
		CHD5	<780..>822	CDD:282299	19/41 (46%)
		P-loop_NTPase	<1088..1182	CDD:304359	77/93 (83%)
smc3	NP_999854.1	Smc	1..1193	CDD:224117	625/1195 (52%)
		ABC_SMC3_euk	3..>158	CDD:213239	129/154 (84%)
		RILP-like	<222..337	CDD:304877	37/114 (32%)
		BAR	<388..>482	CDD:299863	37/96 (39%)
		SMC_hinge	530..642	CDD:214944	61/111 (55%)
		MIT_CorA-like	<700..>836	CDD:294313	50/135 (37%)
		P-loop_NTPase	<1104..1198	CDD:304359	77/93 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592418
Domainoid	1	1.000	1174	1.000	Domainoid score	I14
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3974
Inparanoid	1	1.050	1250	1.000	Inparanoid score	I168
OMA	1	1.010	-	-		QHG54174
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	1	1.000	-	-		FOG0003940
OrthoInspector	1	1.000	-	-		oto40705
orthoMCL	1	0.900	-	-		OOG6_101525
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1353
SonicParanoid	1	1.000	-	-		X3237
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.700