Protein Alignment SMC3 and Smc6

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001101484.1
• Gene: Smc6 / 313961
• RGDID: 1311214
• Length: 1097
• Species: Rattus norvegicus
• Alignment Length: 1234
• Identity: 252/1234 - (20%)
• Similarity: 476/1234 - (38%)
• Gaps: 322/1234 - (26%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNV--VVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |:.|.::.|..:   :::.||....||  |||.||||||....|:...|..:..   ...|.|.|
  Rat    54 IESIQLRNFMCH---SMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAV---ATNRGSSL 112

  Fly    66 HEGTGARVISAYVEIIFDNSDN---RVPIDKEEIFLRR---VIGAKKDQYFLNKKVV---PRNEV 121
            .....|...||.:.|...|..:   |..:..:.|.:::   |.|::..:....|..|   .:.|:
  Rat   113 KGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEEL 177

  Fly   122 VNLLESAGFSSSNPYYIVKQGKINQMATA---ADSYRLKLLREVAGTRVYDERKEESLNLLRETD 183
            :.:|:.......||..::.|....|...:   .|.|:..:    ..|::  |:.:|..:.:.||.
  Rat   178 IAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFM----KATQL--EQMKEDYSYIMETK 236

  Fly   184 SKVEKISEYLKTIEDRLQTLEE---EKEELKEYQKWDKTRRT-LEYIRYETELKDTKKALDELQL 244
               |:..|.:...|:||..|:.   ||||..:......|.:| |||:::|.    ....::|::.
  Rat   237 ---ERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEM----AWAVVNEIEK 294

  Fly   245 QRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTI 309
            |..:..|..||......|...|:::.|..|.:|:||.:
  Rat   295 QLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYK--------------------------- 332

  Fly   310 VDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVK-------PKYEAMKRK-EEDCSRELQ 366
             |:.|:::..::.......|...||..:..|.:..:|.:       .:|:|:|:. |:.|.|..:
  Rat   333 -DIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEE 396

  Fly   367 LKEQKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLG 431
            ||:...:.|..::      ..|:.|..|:..::|::..|                     |..:.
  Rat   397 LKKSTDQSLEPER------LERQKRICWLKEKVKALQDQ---------------------ENTVN 434

  Fly   432 QKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRA-DQ 495
            |::|:....:|:.:.:.....::..|::.|...:|....||...:|...::...|...|..| |.
  Rat   435 QEVEQFEQAIEKDKQEHVRIKREDVEVRHTLSYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDD 499

  Fly   496 AL--RSMAGKPI--LNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAA 556
            |.  |....|||  |..|..:|            ..|:|.|     ||  ||.|.:..|  ....
  Rat   500 AYRRRQFTHKPIGPLGACIHLR------------DPELALA-----IE--SCLKGLLQA--YCCH 543

  Fly   557 NRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDD-----------PDSIPM 610
            |.....:::|         .|.|...||      .:|.|:.:.::.::           |:...:
  Rat   544 NHADERVLQS---------LMKKFYPPG------TSRPQIIVSEFRNEVYDVRLRAAYHPEFPTV 593

  Fly   611 ISKLKYDEQHDKALRYIFGKTLI-CRNLE-----------RATELAKSTGLDC---VTLDGDQVS 660
            ::.|:.|..       :...:|| .|::|           ||...::....:|   .|.|||||
  Rat   594 LTALEIDNA-------VVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQV- 650

  Fly   661 SKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQ 725
                ..|.|:::..:|                 .|.||:          :::|.:|::: ||
  Rat   651 ----FAGRYYSSESTR-----------------PKFLSR----------DVDSEISDLE-TE--- 680

  Fly   726 GKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLS 790
                  .|..:|.|..::..|..:|:.....|..|.:|:...:           |:|.::...:|
  Rat   681 ------IENKKGHIMNLQHRLSALEKDIKRNEELLKRCQLHYK-----------EIKMKIRKNIS 728

  Fly   791 SQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDR 855
              :.||::.:        :|::......::.|..:||:...::               |.::|.:
  Rat   729 --EIRELENI--------EEHQSVDIATLEDEAEENKIKMQMV---------------EKNMEQQ 768

  Fly   856 KRKLNNCKTELVSAEKR---IKKVNSDLEEIEKRVMEAVQL-------QKELQQELETHVRKEKE 910
            |..:.|.||..:.||.:   ||...:.|.|:...:.:.:.|       ||..:|..|.   |:||
  Rat   769 KENMENLKTLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYED---KQKE 830

  Fly   911 AEENLNKDSKQLEKWSTKENMLNEKIDE----CTEKIASLGAVPLVDPSYTRMSLKNIFKELEKA 971
            ..:.|||..::|:   .||..|.||:.:    |.|:|....:..::|
  Rat   831 HMDTLNKKRRELD---MKEKELQEKMSQARQICPERIEVKKSASILD------------------ 874

  Fly   972 NQHLKKYNHVNKKALDQFLSFSEQKE--KLYRRKEE--LDIGDQKIHMLIQSLEMQKVEAIQFTF 1032
                |:.|.:.:|...:..|..:::|  |.|:...|  ||: |.|:..|.:.:::  :|.|....
  Rat   875 ----KEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDL-DSKVRTLRRFIKL--LEEIMTHR 932

  Fly  1033 RQVAQNFTK--------VFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVE 1089
            .:..|.|.:        .|..|:...| :......|::.:.:...|:..:            |.:
  Rat   933 YKTYQQFRRCLTLRCKLYFDNLLSQRA-YCGKMNFDHKNETLSISVQPGE------------GNK 984

  Fly  1090 AEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQF 1153
            |...:|..||||::|...:..|.|:.....:||...||.|..:|.::|:...:||.:::|:.:|
  Rat   985 ASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDMILKMADSQRF 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	252/1234 (20%)
		ABC_SMC3_euk	3..>159	CDD:213239	40/169 (24%)
		SMC_hinge	533..643	CDD:214944	23/132 (17%)
		TMPIT	678..>760	CDD:285135	13/81 (16%)
		CHD5	<780..>822	CDD:282299	6/41 (15%)
		P-loop_NTPase	<1088..1182	CDD:304359	20/66 (30%)
Smc6	NP_001101484.1	Smc	54..1075	CDD:224117	252/1234 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810