Protein Alignment SMC3 and Smc1b

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: XP_038934778.1
• Gene: Smc1b / 300121
• RGDID: 1308791
• Length: 1249
• Species: Rattus norvegicus
• Alignment Length: 1328
• Identity: 299/1328 - (22%)
• Similarity: 548/1328 - (41%)
• Gaps: 267/1328 - (20%)

  Fly     2 HIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLH 66
            |::.::::.|||::.:.|:.|| ||...::|.|||||||...|:.||:.::.|:||.:..|.|:|
  Rat     3 HLELLLVENFKSWRGRQVIGPF-KRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKNIQELIH 66

  Fly    67 EGTGARV-----ISAYVEIIFDNSDNRVPIDKEEIFLRRVIG-AKKDQYFLNKKVVPRNEVVNLL 125
               ||.:     .||.|.||:.....     :|:.|.|.:.| ....::....|.|.|:..|..|
  Rat    67 ---GAHIGKPVSSSASVTIIYVEDSG-----EEKTFTRIIRGRGGCSEFHFGDKPVSRSVYVAQL 123

  Fly   126 ESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKIS 190
            |:.|........:|.||.:..::......|.:...|::.:..:....|.....|::.:...:...
  Rat   124 ENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHF 188

  Fly   191 EYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKI 255
            ...|.:....:..:.||||.:.||.      .||      |||..|..|...||.  .:.:|..:
  Rat   189 NRKKNVAAERKHAKIEKEEAEHYQS------LLE------ELKTNKIQLMLFQLY--YNEEKINV 239

  Fly   256 YNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDN 320
            .|.|::.....:..|:..|...:..:::.|::..:|..:.||..:|...::..   ||.:.....
  Rat   240 LNTELEHMDRNLSVVKDTLSHHENIIKAKKKDYGMLTRQLQQTAKELKSVEAV---LNQKRPQYI 301

  Fly   321 KSKERADQELKNL---KVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRG 382
            |:||.....||.|   |..|.:.||:....:....|:..:..|..|..:..|::.:|....:||.
  Rat   302 KAKENTSHHLKKLDLSKKLITDNEKQCAKQEDGIRALVAELVDLDRAWRSFEKQMEEKILHKGRD 366

  Fly   383 SQF-SSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKD-LGQKIEEH---SSELE 442
            .:. :|:.||.|    |||   :|.|.::....:.:|.|:.:..:||: |..:...|   ...|:
  Rat   367 IELENSQLDRYK----ELK---EQVRRRVGIMTQQLEKLQWEQKAEKERLAFERRRHGDTQGNLK 424

  Fly   443 QLRLQIDEHNK---KYYELKKT--------KDQHQSMRNELWRKETQMTQQLQTHKEELSRADQA 496
            |::.||:||.|   |..|..||        |.|.:::..|:...:::|::.    .||||.....
  Rat   425 QIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALIKEIDNTKSRMSEV----NEELSLIRNE 485

  Fly   497 LRSMAGKPILNGCDSVRKVLDSFVERGGQSAEI----ARAY----YGPVIENFSCDKTIYTAVEV 553
            |::.       |.|:...      :|..:.||:    .|.|    :|.:::  .| ..|:...::
  Rat   486 LQNA-------GIDNHEG------KRQRKRAEVLEHLKRLYPDSVFGRLLD--LC-HPIHKKYQL 534

  Fly   554 TAANRLFHH-----IVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVK-IHDYPDDPDSIPM-- 610
             |..:||..     :|.||......::.:.:.:...| ||:.|:.|.:| |::...:.....|
  Rat   535 -AVTKLFGRYMVAIVVASEKVAKDCIRFLKEERAEPE-TFLALDYLDIKPINERLREIKGCKMMI 597

  Fly   611 -ISKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLD---CVTLDGDQVSSKGSLTGGYFN 671
             :.|.:: .|..|.::::.|..|:|..:|.|..:|.. |.:   .|.|||......|.::||..:
  Rat   598 DVIKTQF-PQLKKVIQFVCGNGLVCETVEEARHIAFG-GPERRKAVALDGTLFLKSGVISGGSSD 660

  Fly   672 TSRSRL--------EMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKS 728
            .....|        .::.||.:...::.|..|.|.|        |.::..|.:.:|.|.|:...|
  Rat   661 LKHKALCWDEKELHSLRDKRNQLVQELKELMKTLRK--------ETDLKQIQALVQGTNTRLKYS 717

  Fly   729 KDVFEKVQ--------GEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQEL 785
            ::..|.::        .|...::.||:.|:.........:.:.:..:|........:|.::.|:.
  Rat   718 QNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDKVEDDIFQDF 782

  Fly   786 MSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRK------------------NKLDNLL 832
            ...:..::.||.:  |..::: .|||.:   :|::||.:|                  ||:|.|.
  Rat   783 CEEIGVENIREFE--NKHVKQ-QQENDQ---KRLEFEKQKTRLNIQLEYSRNQLKKKLNKIDTLK 841

  Fly   833 ---------INNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVM 888
                     |:||.:..:|.::.::|:.|     |....|..|.:....|:|::..:||..|:.:
  Rat   842 TTIQKGREDIDNLKKTEEECLKIVEELMV-----KQEQVKEVLATQSSNIEKIHIQIEEERKKFL 901

  Fly   889 ----EAVQLQKEL--------QQELETHVRKEKEAEENLNKDSK-----------------QLEK 924
                |..:||||:        |::||.|         ||..|.|                 ::|.
  Rat   902 AVDREVGKLQKEVVIIQGSLEQKQLEKH---------NLLLDCKVQDIDISLMLGSLEDIIEVEL 957

  Fly   925 WSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNI--FKELE------------------ 969
            ..|:.......|   .||.||:    .:|.|..|...|.:  .||:|
  Rat   958 TETESTQATADI---YEKEASI----QIDYSPLREDWKALQSDKEVEAHLTLLLQQVASQENTLL 1015

  Fly   970 -------KANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEA 1027
                   :|.::||......:::.|.|  .:.:||....|:|            .:.::.::.:|
  Rat  1016 KTAAPNLRAQENLKAVRDKFQESADAF--EASRKEARICRQE------------FEQVKRRRYDA 1066

  Fly  1028 IQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEM 1092
            ....|..::.:..:::|||....:....|..::.|...::            ||..:........
  Rat  1067 FSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLD------------GISYNCVAPGKRF 1119

  Fly  1093 REMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS-DTAQFITT 1156
            ..|:.||||:|.:.||||:|::....||||::.||:|.|||..:...|:..|.|.| :..|.|..
  Rat  1120 MPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSGYIKEQSQEQFQMIII 1184

  Fly  1157 TFRPELLENAHKFYGVRFRNKVSHIDCV 1184
            :.:.|....|....||    ...|.:|:
  Rat  1185 SLKEEFYSRADALIGV----YPEHDECM 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	297/1322 (22%)
		ABC_SMC3_euk	3..>159	CDD:213239	47/161 (29%)
		SMC_hinge	533..643	CDD:214944	26/122 (21%)
		TMPIT	678..>760	CDD:285135	17/89 (19%)
		CHD5	<780..>822	CDD:282299	8/41 (20%)
		P-loop_NTPase	<1088..1182	CDD:304359	32/94 (34%)
Smc1b	XP_038934778.1	Smc	3..1201	CDD:224117	297/1319 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740