DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and Smc5

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	XP_006231245.1	Gene:	Smc5 / 293967	RGDID:	1307492	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	1244	Identity:	244/1244 - (19%)
Similarity:	486/1244 - (39%)	Gaps:	318/1244 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLLH 66
            |.:|.::.|.:| |...|.| ....|:::|.||:|||:...||...|:.:...: |.::....:.
  Rat    53 IVRIAMENFLTY-DICEVSP-GPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVK 115

  Fly    67 EGTGARVISAYVEI-IFDNSDNRVPIDKEEIFLRRVIGAKKDQ--YFLNKKVVPRNEVVNLLESA 128
            .|..    ...||| :|..|.|        :.:.|.|...|:|  :|:|||.|.:..|...:.:.
  Rat   116 RGCS----KGLVEIELFRTSGN--------LIITREIDVIKNQSFWFINKKPVTQKIVEEQVAAL 168

  Fly   129 GFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKV--EKISE 191
            .....|....:.|.|:.:.|                       |...:.||..|:..:  .::..
  Rat   169 NIQVGNLCQFLPQDKVGEFA-----------------------KLSKIELLEATEKSIGPPEMHR 210

  Fly   192 Y---LKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELK---DTKKALDELQLQRKSSS 250
            |   ||...::.:.||...:|..||  .||..:..|  ||:.:::   :.|:.||.:::     .
  Rat   211 YHCELKNFREKEKQLETSCKEKTEY--LDKMIQRNE--RYKQDVERFYERKRHLDLIEM-----L 266

  Fly   251 DKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVD-LND 314
            :.|:.: :|.:..:::.:.|:......|::|:..||.:..:....:::.|::..|::.|.: ..|
  Rat   267 EAKRPW-VEYENVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQRRTLEVRIKEKATD 330

  Fly   315 EVQGDNKSK------ERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRK 373
            ..:...|.|      ||.|:.:|.|:..:..::.|..|.:.:....::..||...||:..|
  Rat   331 IKEASQKCKQRQDLIERKDRHIKELQQALTVKQNEEQDRQKRISNTRKMIEDLQNELRTAE---- 391

  Fly   374 ELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQK----I 434
                      ...:.:.:...|||:|:.:.:   :|.....:::     |...||::.:|    :
  Rat   392 ----------NCENLQPQIDAITNDLRRVQE---EKALCEGEII-----DKQREKEMLEKQKRSV 438

  Fly   435 EEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWR------KETQMTQQLQTHKEELSRA 493
            .:|.:..:.|..|.::..::.|  :.|.|....:||...|      :...:|..::.:|.
  Rat   439 SDHITRFDNLMNQKEDKLRQRY--RDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKN----- 496

  Fly   494 DQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANR 558
                    .|.:.|...|  ..|.:||....:..||   :...|.:|.........|.:::.|::
  Rat   497 --------AKYVENHISS--NDLRAFVFESQEDMEI---FLREVRDNKKLRVNAVIAPKISYADK 548

  Fly   559 LFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKA 623
                         ...:.:|:||..|..:::.      ::.|.||     |::|.|        .
  Rat   549 -------------APSRSLNELKQYGFFSYLR------ELFDAPD-----PVMSYL--------C 581

  Fly   624 LRYIFGKTLIC--RNLERATELAKSTGLDCVTLDGDQ------------VSSKGSLTGGYFNTSR 674
            .:|...:..:.  |..||...:.:.|.|..:....::            :||..||....|.|..
  Rat   582 CQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVT 646

  Fly   675 SRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEI 739
            ..||.::          ..|::|.::..:|::.::.:.::....:..|.|           ..|:
  Rat   647 VDLEQRR----------HLEEQLKEINRKLEAVDSGLVALRDTNRHLELK-----------DNEL 690

  Fly   740 RLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDI 804
            ||.|:||:.    |..|:|                     :|:|::.|.|:|     |..:..|.
  Rat   691 RLKKKELLE----RKTKKR---------------------QLEQKISSKLAS-----IRLMEQDT 725

  Fly   805 RRLNQENKEAFTQRMQFEVRKNKLDNLL------INNLFRRRDELIQALQEISVEDRKRKLNNCK 863
            ..|.:|.::|.|:..:..|:|.||...|      ..:|..::.:||  ||..:|...|.||   :
  Rat   726 CNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSLHIQKVDLI--LQNTTVISEKNKL---E 785

  Fly   864 TELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEE--NLNKDSKQLEKWS 926
            .:.:::..:::.......|::......:|..|||.          |.|.:  ||:.|....:::.
  Rat   786 ADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELM----------KRARQVCNLSADQAVPQEFQ 840

  Fly   927 TKENMLNEKIDECTEKIASLGAVPLV------DPSYTRMSLKNIFKELE----KANQHLKKYNHV 981
            |:                    ||.:      .|......|.|...|::    :.......:..:
  Rat   841 TQ--------------------VPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGL 885

  Fly   982 NKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQF--TFRQVAQNFTKVFK 1044
            |...::::            .|.|::     |..|.:.|:.:|||..::  ...||.:.:....|
  Rat   886 NPSVVEEY------------TKREIE-----IQQLTEELKGKKVELDEYRENISQVKERWLNPLK 933

  Fly  1045 KLVPMGAGFLILKTKDNE-----------GDEMEKEVENSDAFT--GIGIRVSFTGVEAEMREM- 1095
            :||          .|.||           ..|::...||.:.:.  ||.|||.|.. ..::.|:
  Rat   934 ELV----------EKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRS-STQLHELT 987

  Fly  1096 -NQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS---DTAQFITT 1156
             :..|||::|:..:..:.::|:.:..||.:.|||:|.:|.::.:.|..|:...:   :|:|:...
  Rat   988 PHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFI 1052

  Fly  1157 TFRPELLEN 1165
            |  |:||:|
  Rat  1053 T--PKLLQN 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	244/1244 (20%)
		ABC_SMC3_euk	3..>159	CDD:213239	39/159 (25%)
		SMC_hinge	533..643	CDD:214944	18/111 (16%)
		TMPIT	678..>760	CDD:285135	15/81 (19%)
		CHD5	<780..>822	CDD:282299	11/41 (27%)
		P-loop_NTPase	<1088..1182	CDD:304359	22/83 (27%)
Smc5	XP_006231245.1	ABC_SMC5_euk	51..>196	CDD:213244	40/179 (22%)
		Smc	53..1055	CDD:224117	240/1238 (19%)
		ABC_SMC5_euk	<975..1077	CDD:213244	24/88 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810