DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and psm3

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_593260.1	Gene:	psm3 / 2543010	PomBaseID:	SPAC10F6.09c	Length:	1194	Species:	Schizosaccharomyces pombe

Alignment Length:	1223	Identity:	462/1223 - (37%)
Similarity:	714/1223 - (58%)	Gaps:	59/1223 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |:|.:|:|||||||||.||:||....|||:||||||||||||.||:|||||.:|||..|:||:||
pombe     1 MYITKIVIQGFKSYKDYTVIEPLSPHHNVIVGRNGSGKSNFFAAIRFVLSDAYTHLSREERQALL 65

  Fly    66 HEGTGARVISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGF 130
            |||.||.|:|||||:.|.|:|||.|..|.|:.|||.||.|||:|.|:||.|.:.||:||||||||
pombe    66 HEGPGATVMSAYVEVTFANADNRFPTGKSEVVLRRTIGLKKDEYSLDKKTVSKTEVINLLESAGF 130

  Fly   131 SSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLKT 195
            |.|||||||.||::..:..|.||.||:||:|||||::|:.|:.||..::.||..|.|||.|.|:.
pombe   131 SRSNPYYIVPQGRVTSLTNAKDSERLELLKEVAGTQIYENRRAESNKIMDETIQKSEKIDELLQY 195

  Fly   196 IEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIEI 260
            ||:||:.|||||.:|..|.|.|..||.|||..|..|..:....||.|:..|.::.::....:...
pombe   196 IEERLRELEEEKNDLAVYHKKDNERRCLEYAIYSREHDEINSVLDALEQDRIAALERNDDDSGAF 260

  Fly   261 QKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKER 325
            .:.:|:|:.::..:.|....::..:.|:.....:...:::.|..|:|....|:.:::...|.:..
pombe   261 IQREERIERIKAEITELNHSLELLRVEKQQNDEDYTNIMKSKVALELQSSQLSRQIEFSKKDESS 325

  Fly   326 ADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSRED 390
            ....|..|:..|:|:|.||.::.|||.|:..:.:|.::.:.|.:.:::.|..||.|.|||:::::
pombe   326 KLNILSELESKISEKENELSEILPKYNAIVSEADDLNKRIMLLKNQKQSLLDKQSRTSQFTTKKE 390

  Fly   391 RDKWITNELKSI------SKQTRDKI-AHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQI 448
            ||:||.|:|..|      :|:..|.: ..:.::..:||...:.:|::...:|.....:.||...|
pombe   391 RDEWIRNQLLQINRNINSTKENSDYLKTEYDEMENELKAKLSRKKEIEISLESQGDRMSQLLANI 455

  Fly   449 DEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVR 513
            ...|::       |:.....|..|||:|.::...::..|::|||:::||.:...:...||..:|:
pombe   456 TSINER-------KENLTDKRKSLWREEAKLKSSIENVKDDLSRSEKALGTTMDRNTSNGIRAVK 513

  Fly   514 KVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMN 578
            .:.:.....|         ||||:.|.|..|.....|||.||.|.|||.:|:::...||||..:.
pombe   514 DIAERLKLEG---------YYGPLCELFKVDNRFKVAVEATAGNSLFHIVVDNDETATQILDVIY 569

  Fly   579 KLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATEL 643
            | :..|.|||||||:|:.|...|||..|::|:|..|::|.:.|.|::.:|.||::|.::|.|::.
pombe   570 K-ENAGRVTFMPLNKLRPKAVTYPDASDALPLIQYLEFDPKFDAAIKQVFSKTIVCPSIETASQY 633

  Fly   644 AKSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTE 708
            |:|..|:.:||.||:...||:||.||.:...|||:..|....|..:.::.::.|.|.|:|::|.:
pombe   634 ARSHQLNGITLSGDRSDKKGALTAGYRDYRNSRLDAIKNVKTYQIKFSDLQESLEKCRSEIESFD 698

  Fly   709 NNINSIVSEMQKTETKQGKSKDVFEK----VQGEIRLMKEELVRIEQYRAPKERSLAQCKASLES 769
            ..|.:.:.::||.:.    |...||:    ::.|:..:..|...:::....|.|.|......|.:
pombe   699 QKITACLDDLQKAQL----SLKQFERDHIPLKDELVTITGETTDLQESMHHKSRMLELVVLELHT 759

  Fly   770 MTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLIN 834
            :....:.|::||..| |..|..:|...:..|:..|..|:.|......:|...|.||..|:..|..
pombe   760 LEQQANDLKSELSSE-MDELDPKDVEALKSLSGQIENLSHEFDAIIKERAHIEARKTALEYELNT 823

  Fly   835 NLFRRRDELIQALQEISVEDR--KRKLNNCKTELVSAEKR---IKKVNSDLEEIEKRVMEAVQLQ 894
            ||:.||:.|   ..||..::|  :.:||:.|..|:..|.:   ||..:|.|||..:|:...:
pombe   824 NLYLRRNPL---KAEIGSDNRIDESELNSVKRSLLKYENKLQIIKSSSSGLEEQMQRINSEI--- 882

  Fly   895 KELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVP---LVDPSY 956
            .:.:.|||:....:.|....:.:|:|..|:.:.|.::|..:..||.|||.|||.:|   .:  .|
pombe   883 SDKRNELESLEELQHEVATRIEQDAKINERNAAKRSLLLARKKECNEKIKSLGVLPEEAFI--KY 945

  Fly   957 TRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLE 1021
            ...|...|.|:|.|.|:.||.|..|||||.:||.:|::|::.|..|:|||....:.|..|...|:
pombe   946 VSTSSNAIVKKLHKINEALKDYGSVNKKAYEQFNNFTKQRDSLLARREELRRSQESISELTTVLD 1010

  Fly  1022 MQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEV----------ENSDAF 1076
            .:|.|||:.||:|||::|:::|.||||.|.|.|::..:......:|:::          .:.|.:
pombe  1011 QRKDEAIERTFKQVAKSFSEIFVKLVPAGRGELVMNRRSELSQSIEQDISMDIDTPSQKSSIDNY 1075

  Fly  1077 TGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVA 1141
            |||.|||||...:.|...:||||||||||.||.|||:||:||||||.:.||.|..|||.:|.|:|
pombe  1076 TGISIRVSFNSKDDEQLNINQLSGGQKSLCALTLIFAIQRCDPAPFNILDECDANLDAQYRSAIA 1140

  Fly  1142 NMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVE 1194
            .|:.|:|.|:|||.||||||:::.|..||||.|.:|||.::.:::|||..|||
pombe  1141 AMVKEMSKTSQFICTTFRPEMVKVADNFYGVMFNHKVSTVESISKEEAMAFVE 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	454/1206 (38%)
		ABC_SMC3_euk	3..>159	CDD:213239	102/155 (66%)
		SMC_hinge	533..643	CDD:214944	48/109 (44%)
		TMPIT	678..>760	CDD:285135	17/85 (20%)
		CHD5	<780..>822	CDD:282299	11/41 (27%)
		P-loop_NTPase	<1088..1182	CDD:304359	55/93 (59%)
psm3	NP_593260.1	Smc	1..1192	CDD:224117	459/1220 (38%)
		ABC_SMC3_euk	3..>166	CDD:213239	108/162 (67%)
		SMC_hinge	522..633	CDD:214944	49/120 (41%)
		P-loop_NTPase	<1085..1180	CDD:304359	55/94 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	781	1.000	Domainoid score	I6
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3974
Inparanoid	1	1.050	801	1.000	Inparanoid score	I67
OMA	1	1.010	-	-		QHG54174
OrthoFinder	1	1.000	-	-		FOG0003940
OrthoInspector	1	1.000	-	-		oto101181
orthoMCL	1	0.900	-	-		OOG6_101525
Panther	1	1.100	-	-	LDO	PTHR43977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1353
SonicParanoid	1	1.000	-	-		X3237
TreeFam	1	0.960	-	-
	14	13.860