Protein Alignment SMC3 and SMC5

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_055925.2
• Gene: SMC5 / 23137
• HGNCID: 20465
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1227
• Identity: 251/1227 - (20%)
• Similarity: 498/1227 - (40%)
• Gaps: 284/1227 - (23%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLLH 66
            |.:|.::.|.:| |...|.| ....|::||.||:|||:...||...|:.:...: |.::....:.
Human    53 IVRISMENFLTY-DICEVSP-GPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVK 115

  Fly    67 EGTGARVISAYVEI-IFDNSDNRVPIDKEEIFLRRVIGAKKDQ--YFLNKKVVPRNEVVNLLESA 128
            .|..    ...||| :|..|.|.|        :.|.|...|:|  :|:|||...:..|...:.:.
Human   116 RGCS----RGMVEIELFRASGNLV--------ITREIDVAKNQSFWFINKKSTTQKIVEEKVAAL 168

  Fly   129 GFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYL 193
            .....|....:.|.|:.:.|..:   :::||          |..|:|:.     ..::.|....|
Human   169 NIQVGNLCQFLPQDKVGEFAKLS---KIELL----------EATEKSIG-----PPEMHKYHCEL 215

  Fly   194 KTIEDRLQTLEEEKEELKEY-QKWDKTRRTLEYIRYETELK---DTKKALDELQLQRKSSSDKKK 254
            |.:.::.:.||...:|..|| ||..:...     ||:.:::   :.|:.||.:::     .:.|:
Human   216 KNLREKEKQLETSCKEKTEYLQKMVQRNE-----RYKQDVERFYERKRHLDLIEM-----LEAKR 270

  Fly   255 IYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGD 319
            .: :|.:..:::.::|:......|::|:..||.:..:....:::..|:..|:..|.:...::
Human   271 PW-VEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDI--- 331

  Fly   320 NKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQ 384
                :.|.|:.|..:..|..::|.:::::......:.:|.|..|.:                |:.
Human   332 ----KEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRI----------------GNT 376

  Fly   385 FSSREDRDKWITNELKSIS-----KQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQL 444
            ....||    :.||||:..     :...|.|.:..:.::|.|  |..|.::..|..|..: ||:.
Human   377 RKMIED----LQNELKTTENCENLQPQIDAITNDLRRIQDEK--ALCEGEIIDKRRERET-LEKE 434

  Fly   445 RLQIDEHNKKYYELKKTKDQ--HQSMRNE----LWRKETQMTQQLQTHKEELSRADQALRSMAGK 503
            :..:|:|..::..|...|:.  .|..|:.    ||         |:.::::       .:....:
Human   435 KKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLW---------LRNNRDK-------FKQRVCE 483

  Fly   504 PILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIV---E 565
            ||:...:........::|....|.:: ||:   |.|:.. |..::.. ||....:|..:.|   :
Human   484 PIMLTINMKDNKNAKYIENHIPSNDL-RAF---VFESQE-DMEVFLK-EVRDNKKLRVNAVIAPK 542

  Fly   566 SEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGK 630
            |.|......:.:|:||..|..:::.      ::.|.||     |::|.|        ..:|...:
Human   543 SSYADKAPSRSLNELKQYGFFSYLR------ELFDAPD-----PVMSYL--------CCQYHIHE 588

  Fly   631 TLIC--RNLERATELAKSTGLDCVTLDGDQ------------VSSKGSLTGGYFNTSRSRLEMQK 681
            ..:.  :..||...:.:.|.|..:....::            :||..||....|.|....||.::
Human   589 VPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRR 653

  Fly   682 KRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEEL 746
                      ..|::|.::..:|::.::.:.::     :..:|..:.||      .|:|..|:||
Human   654 ----------HLEEQLKEIHRKLQAVDSGLIAL-----RETSKHLEHKD------NELRQKKKEL 697

  Fly   747 VRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQEN 811
            :.    |..|:|                     :|:|::.|.|.|....|.|..|     |.:|.
Human   698 LE----RKTKKR---------------------QLEQKISSKLGSLKLMEQDTCN-----LEEEE 732

  Fly   812 KEAFTQRMQFEVRKNKLDNLLIN------NLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAE 870
            ::|.|:..:..|:|.||...|.|      :|..::.:||  ||..:|...|.||   :::.::|.
Human   733 RKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLI--LQNTTVISEKNKL---ESDYMAAS 792

  Fly   871 KRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEE--NLNKDSKQLEKWSTKENMLN 933
            .:::.......|:::.....:|..|||.          |.|.:  ||..:....:::.|:
Human   793 SQLRLTEQHFIELDENRQRLLQKCKELM----------KRARQVCNLGAEQTLPQEYQTQ----- 842

  Fly   934 EKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEK 998
                           ||.: |:....||..:|::|......:.......:.....|...:....:
Human   843 ---------------VPTI-PNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQ 891

  Fly   999 LYRRKEELDIGDQKIHMLIQSLEMQKVEAIQF--TFRQVAQNFTKVFKKLVPMGAGFLILKTKDN 1061
            .|.::||      :|..|.:.|:.:|||..|:  ...||.:.:....|:||          .|.|
Human   892 EYTKREE------EIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELV----------EKIN 940

  Fly  1062 E-----------GDEMEKEVENSDAFT--GIGIRVSFTGVEAEMREM--NQLSGGQKSLVALALI 1111
            |           ..|::...||.:.:.  ||.|||.|.. ..::.|:  :..|||::|:..:..:
Human   941 EKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRS-STQLHELTPHHQSGGERSVSTMLYL 1004

  Fly  1112 FSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS---DTAQFITTTFRPELLEN 1165
            .::|:.:..||.:.|||:|.:|.::.:.|..|:...:   :|:|:...|  |:||:|
Human  1005 MALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFIT--PKLLQN 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	251/1227 (20%)
SMC5	NP_055925.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	40/159 (25%)
		SMC_prok_B	196..1053	CDD:274008	205/1057 (19%)
		Flexible hinge	446..646		43/240 (18%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<975..1077	CDD:476819	24/88 (27%)