Protein Alignment SMC3 and Smc5

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001413081.1
• Gene: Smc5 / 226026
• MGIID: 2385088
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1245
• Identity: 245/1245 - (19%)
• Similarity: 486/1245 - (39%)
• Gaps: 319/1245 - (25%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLLH 66
            |.:|.::.|.:| |...|.| ....|:::|.||:|||:...||...|:.:...: |.::....:.
Mouse    53 IVRIAMENFLTY-DICEVSP-GPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVK 115

  Fly    67 EGTGARVISAYVEI-IFDNSDNRVPIDKEEIFLRRVIGAKKDQ--YFLNKKVVPRNEVVNLLESA 128
            .|..    ...||| :|..|.|        :.:.|.|...|:|  :|:|||.|.:..|...:.:.
Mouse   116 RGCS----KGLVEIELFRTSGN--------LIITREIDVIKNQSFWFINKKPVTQKIVEEQVAAL 168

  Fly   129 GFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT----RVYDERKEESLNLLRETDSKVE-- 187
            .....|....:.|.|:.:.|..:....|:...:..|.    |.:.|.|.     .||.:.::|
Mouse   169 NIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHRYHCELKN-----FREKEKQLETS 228

  Fly   188 --KISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSS 250
              :.:|||   |..:|..|..|::::.:.   :.:|.|:.|    |:.:.|:...|.:
Mouse   229 CKEKTEYL---EKMVQRNERYKQDVERFY---ERKRHLDLI----EMLEAKRPWVEYE------- 276

  Fly   251 DKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQ-QQLLREKTKLDLTIVDLND 314
                    .:::..|.:|.::..:||..:|:    :|..:.||.: :::.|::..|::.|.:.:.
Mouse   277 --------NVRQEYEGVKLIRDRVKEEVRKL----KEGQIPMTRRIEEIDRQRHTLEVRIKEKST 329

  Fly   315 EV-QGDNKSK------ERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKR 372
            :: :...|.|      ||.|:::|.|:..:..::.|..|.:.:....::..||...||:..|
Mouse   330 DIKEASQKCKQRQDLIERKDRQIKELQQALTVKQNEELDRQKRISNTRKMIEDLQSELKTAE--- 391

  Fly   373 KELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQK---- 433
                       ...:.:.:...:||:|:.:.:   :|.....:::     |...||::.:|
Mouse   392 -----------NCENLQPQIDTVTNDLRRVQE---EKALCEGEII-----DKQREKEMLEKQRRS 437

  Fly   434 IEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWR------KETQMTQQLQTHKEELSR 492
            :.:|.:..:.|..|.::..::.|  :.|.|....:||...|      :...:|..::.:|.
Mouse   438 VSDHITRFDNLMNQKEDKLRQRY--RDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKN---- 496

  Fly   493 ADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAAN 557
                     .|.:.|...|  ..|.:||....:..||   :...|.:|.........|.:::.|:
Mouse   497 ---------AKYVENHISS--NDLRAFVFESQEDMEI---FLREVRDNKKLRVNAVIAPKISYAD 547

  Fly   558 RLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDK 622
            :             ...:.:|.||..|..:::.      ::.|.||     |::|.|
Mouse   548 K-------------APSRSLNDLKQYGFFSYLR------ELFDAPD-----PVMSYL-------- 580

  Fly   623 ALRYIFGKTLIC--RNLERATELAKSTGLDCV------------TLDGDQVSSKGSLTGGYFNTS 673
            ..:|...:..:.  |..||...:.:.|.|..:            ......:||..||....|.|.
Mouse   581 CCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTSVYSNKVISSNTSLKVAQFLTV 645

  Fly   674 RSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGE 738
            ...||.::          ..|::|.::..:|::.::.:.::....:..|.|           ..|
Mouse   646 TVDLEQRR----------HLEEQLKEMNRQLEAVDSGLAALRDTNRHLELK-----------DNE 689

  Fly   739 IRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDD 803
            :||.|:||                    ||..|..:     :|:|::.|.|:|     |..:..|
Mouse   690 LRLKKKEL--------------------LERKTRKR-----QLEQKISSKLAS-----IRLMEQD 724

  Fly   804 IRRLNQENKEAFTQRMQFEVRKNKLDNLL-----INNLFR-RRDELIQALQEISVEDRKRKLNNC 862
            ...|.:|.::|.|:..:..|:|.||...|     |...|: ::.:||  ||..:|...|.||
Mouse   725 TCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSFQIQKVDLI--LQNTTVISEKNKL--- 784

  Fly   863 KTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEE--NLNKDSKQLEKW 925
            :.:.:::..:::.......|::......:|..|||.          |:|.:  ||:.|....:::
Mouse   785 EADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELM----------KKARQVCNLSADQAVPQEF 839

  Fly   926 STKENMLNEKIDECTEKIASLGAVPLV------DPSYTRMSLKNIFKELE----KANQHLKKYNH 980
            .|:                    ||.:      .|......|.|...|::    :.......:..
Mouse   840 QTQ--------------------VPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTG 884

  Fly   981 VNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQF--TFRQVAQNFTKVF 1043
            :|...:                .||....:.:|..|.:.|:.:|||..::  ...||.:.:....
Mouse   885 LNPSVV----------------VEEYSKREVEIQQLTEELQGKKVELDEYRENISQVKERWLNPL 933

  Fly  1044 KKLVPMGAGFLILKTKDNE-----------GDEMEKEVENSDAFT--GIGIRVSFTGVEAEMREM 1095
            |:||          .|.||           ..|::...||.:.:.  ||.|||.|.. ..::.|:
Mouse   934 KELV----------EKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRS-STQLHEL 987

  Fly  1096 --NQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS---DTAQFIT 1155
              :..|||::|:..:..:.::|:.:..||.:.|||:|.:|.::.:.|..|:...:   :|:|:..
Mouse   988 TPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFF 1052

  Fly  1156 TTFRPELLEN 1165
            .|  |:||:|
Mouse  1053 IT--PKLLQN 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	245/1245 (20%)
Smc5	NP_001413081.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	39/156 (25%)
		SMC_prok_B	196..1054	CDD:274008	201/1078 (19%)
		Flexible hinge	441..644		44/254 (17%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<976..1078	CDD:476819	24/88 (27%)