DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMC3 and Ccdc157

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	XP_011241975.1	Gene:	Ccdc157 / 216516	MGIID:	3041210	Length:	754	Species:	Mus musculus

Alignment Length:	409	Identity:	93/409 - (22%)
Similarity:	172/409 - (42%)	Gaps:	86/409 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 VVNLLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSK 185
            |::|.:|....||       .|:..::  ..||..||.|   ....|.....|:|.:|.| .:..
Mouse   249 VISLCQSQNLPSS-------LGQFQKL--VKDSLGLKPL---PAATVGHWAAEQSKDLTR-LNKH 300

  Fly   186 VEKISEYLKTIEDRLQTLEEEKEELKE---------YQKWDKTRRTLEYIRYETELKDTKKALDE 241
            |..:::.:..:..:|:..|.:|:.|::         .|:..:.:|..|    |.|....|...|.
Mouse   301 VGALTQLVGPLRAQLEDAEGQKDGLRKQVSKLEQALQQEQGQRQRQTE----EAERTLAKCEHDR 361

  Fly   242 LQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKE--ERSVLMTEQQQLLREKTK 304
            .||..::...|.|:..:|     ..:|..||:::..:.|.|..:|  ||......|.|.|.|:.:
Mouse   362 HQLLTETCDLKTKVAVLE-----GDLKQQQKSIQAMEAKAQQLEEEGERRAAAERQVQQLEEQVQ 421

  Fly   305 LDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKE 369
            |      |...:.|       |.|:::.....:.:.:..:|.:....|:::.|:....::|...:
Mouse   422 L------LAGRLDG-------ASQQIRWASTELDKEKARVDSMVRHQESLQAKQRTLLQQLDCLD 473

  Fly   370 QKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKI 434
            |:|:||     |||...:...|.: :..:|:|:..   |:.....:|        .::::|.|.:
Mouse   474 QEREEL-----RGSLDEAEAQRSE-LEEQLQSLQS---DREQEQCQL--------QAQQELLQSL 521

  Fly   435 EEHSSELEQ----LRLQIDEHNKKYYELKKTK-------DQHQSMRNELWRKETQMTQQLQTHKE 488
            ::...:|||    |:|.|.|..::..|||:.:       |.||.       :|.|:  |..|..|
Mouse   522 QQEKQDLEQVTTDLQLTISELRQQLEELKERERLLVAFPDLHQP-------EEAQI--QSPTGGE 577

  Fly   489 ELS--RADQALR-SMAGKP 504
            :.:  .|||..| ..||:|
Mouse   578 QAAPVDADQNPRGGPAGRP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	93/409 (23%)
		ABC_SMC3_euk	3..>159	CDD:213239	10/37 (27%)
		SMC_hinge	533..643	CDD:214944
		TMPIT	678..>760	CDD:285135
		CHD5	<780..>822	CDD:282299
		P-loop_NTPase	<1088..1182	CDD:304359
Ccdc157	XP_011241975.1	Smc	<291..569	CDD:224117	69/324 (21%)
Ccdc157	XP_011241975.1	PRK13729	531..>634	CDD:184281	22/75 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930