DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and smc4

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_775360.2 Gene:smc4 / 192332 ZFINID:ZDB-GENE-020419-21 Length:1289 Species:Danio rerio


Alignment Length:1317 Identity:314/1317 - (23%)
Similarity:573/1317 - (43%) Gaps:282/1317 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |..|:.:.||||..:.::.||.||.:.::|.|||||||...::.||.......:|.::...|:|.
Zfish    83 ITHIVNRNFKSYAGEQILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHS 147

  Fly    68 GTG-ARVISAYVEIIFDNSDNRVPIDKE----------EIFLRRVIGAKKDQ---YFLNKKVVPR 118
            ..| ..:.|..||:.|...     ||||          ..::.|..|  ||.   |::|.|....
Zfish   148 SDGHPDIQSCTVEVHFQKI-----IDKEGDDYDVIPDSSFYVARTAG--KDNSSAYYINTKKATF 205

  Fly   119 NEVVNLLESAGFSSSNPYYIVKQGKINQMA-------TAADSYRLKLLREVAGTRVYDERKEESL 176
            .:|..||.|.|....:..:::.||::.|:|       |..|...|:.|.::.|:.    |.:|.:
Zfish   206 KDVGTLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGSC----RLKEPI 266

  Fly   177 NLL-RETDSKVEKISEYL---KTIEDRLQTLEEEKEELKEYQKWD----KTRRTLEY-----IRY 228
            |:| |..::..|:..|.|   |.:|.....||.||.:..::...:    |.|..|.:     ::.
Zfish   267 NILCRRVEALNEQRGEKLNRVKMVEKEKSALEGEKNKAVDFLSLENDIFKKRNLLCHFYVHDLQS 331

  Fly   229 ETELKDTKKALDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMT 293
            ...:|:.:|  .::|...|..|||......|::...|.:|.|:|.|.:..|.::|.||       
Zfish   332 RVSVKEAEK--QQIQEDTKDLSDKSSQLTEEMKSKNEDLKAVEKKLTKLTKYIESQKE------- 387

  Fly   294 EQQQLLREKTKLDLTIVDLNDEVQGDNKSKER-------ADQE-LKNLKVTIAEREKELDDVKPK 350
                   :.|:|||..|::.:::: ..|||.:       .||| |:.::...|..||.:.:...:
Zfish   388 -------KFTQLDLQDVEVREKLK-HTKSKTKKLQKQLQKDQEKLEEVRGVPASSEKIITEASAQ 444

  Fly   351 YEAMKRKEEDCSRELQLKEQKRKEL---YAKQGRGSQFSSREDRDKWITNELKSISK---QTRDK 409
            .|.:::|:       .|:|||..|:   ..::.:|.|    ||::| ...||..:||   :||.:
Zfish   445 KEELEKKK-------LLEEQKLAEVMESLKEETKGLQ----EDKEK-KEKELLELSKSVNETRSR 497

  Fly   410 IAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWR 474
            :        |:   |.||.|:  .:.:|::.:.||       |:....|::|.|..:..|..:  
Zfish   498 M--------DV---AQSELDI--YLSQHNTAINQL-------NQAKSALQETVDTLRERRAAI-- 540

  Fly   475 KETQM---TQQLQTHK-----EELSRADQALRSMAG---------KPILNGCDSVRKVLDSFVE- 521
            |:.|:   .|:.|..|     |::|..|:..|:..|         |..|:...|..||||:.:: 
Zfish   541 KDLQVKIPAQEEQLKKDERELEQISEQDKQTRAQVGDMRQKVAEAKSSLSSNRSRSKVLDTLMQQ 605

  Fly   522 -RGGQSAEIARAYYGPVIENFSCDKTIYTAVEVT--AANRLFHHIVESEYEGTQILKEMNKLKLP 583
             |.|:...|    .|.:.:..:.|:....|:..:  :.:.:....:::..:....||..|    .
Zfish   606 KRSGKIPGI----LGRLGDLGAIDEKYDVAISSSCGSLDNILVDTIDTAQKCVTFLKAQN----I 662

  Fly   584 GEVTFMPLNRLQV--KIHDYPDDPDSIPMI---SKLKYDEQHDKALRYIFGKTLICRNLERATEL 643
            |..||:.|::::|  :.......|::||.:   .::| ||....|..:....||:.::||:||.:
Zfish   663 GVATFIGLDKMKVWQQSMGSISTPENIPRLFDMVRVK-DESVRPAFYFALRDTLVAKDLEQATRV 726

  Fly   644 A--KSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKS 706
            |  |......|||.|..:...|::|||.....:.|:.        :|..|:..::      :|..
Zfish   727 AFQKDKRWRVVTLQGQIIEQAGTMTGGGGRVMKGRMG--------SSVCADVTQE------QLDK 777

  Fly   707 TENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMT 771
            .|:.:|..|:::|..:.::.:.::...|.:.|:|.||..|   |:|           .|:::|:|
Zfish   778 MESALNKEVTQLQDCQKRKNQLEEKVHKARCELRDMKNTL---EKY-----------TATIQSLT 828

  Fly   772 STKSSLEAELKQ-ELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLI-- 833
            ..:..|:.::|. |.....::.|:.:..|:...:....::.:.|..:..:.|....:|..|::  
Zfish   829 EQELHLKPQIKDLEANVIAAAPDKAKQKQMEKSLEAYRKDFEAASNKAGKVEAEVKRLHTLIVDI 893

  Fly   834 --NNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIK--------------KVNSDLEE 882
              :.|..::|:|.|.         ..:|:.|.:.:..|:..||              ::..::.|
Zfish   894 NSHKLKAQQDKLDQI---------NTQLDQCSSAVTKAQVAIKTAGRNLKKSEDGVSRLEQEISE 949

  Fly   883 IEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQ-----------------LEKWSTKEN 930
            .||.:.|..:..|:|:::....::..::|||.|.:...|                 |:|.|....
Zfish   950 NEKLMEELTEQLKKLEEQAGEIMQSYQQAEEALPEVQDQHRAVVQEIKALQEQEHALQKESLSVR 1014

  Fly   931 MLNEKID----ECTEKI-----------------ASLGAVPLVDPSYTR-----MSLKNIFKELE 969
            :..|.||    ||..||                 .....:|.::|...:     ..:||....||
Zfish  1015 LKVEHIDTAITECHNKIKHWQKEASKLCLHHIDGVPAEELPALNPDQLQDIGNPDVIKNEIALLE 1079

  Fly   970 KANQHLKKYNHVNKKALDQFLSFSEQKEKLY-RRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFR 1033
            ....::|.    |..|:.:|    ::||:|| :|..|||                .:...:.:|:
Zfish  1080 DRCANMKP----NLGAIAEF----KKKEELYLQRVAELD----------------DITTQRDSFK 1120

  Fly  1034 QVAQNFTKVFKKLVPMGAGFLIL--KTKDNE-----GDEMEKE-VENSDAFTGIGIRVSFTGVEA 1090
            :..::..|  ::|....|||.|:  |.|:|.     |.:.|.| |::.|.|:. ||..|....:.
Zfish  1121 RGCEDLRK--QRLHEFMAGFNIITNKLKENYQMLTLGGDAELELVDSLDPFSE-GIMFSVRPPKK 1182

  Fly  1091 EMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFIT 1155
            ..:::..||||:|:|.:|||:|::....|.|.|..||||.|||..:...||..|:|.:..||||.
Zfish  1183 SWKKIYNLSGGEKTLSSLALVFALHHFKPTPLYFMDEIDAALDFKNVSIVACYIYEQTKNAQFII 1247

  Fly  1156 TTFRPELLENAHKFYGV 1172
            .:.|..:.|.|.:..|:
Zfish  1248 ISLRNNMFEMADRLIGI 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 314/1317 (24%)
ABC_SMC3_euk 3..>159 CDD:213239 51/176 (29%)
SMC_hinge 533..643 CDD:214944 24/116 (21%)
TMPIT 678..>760 CDD:285135 15/81 (19%)
CHD5 <780..>822 CDD:282299 5/42 (12%)
P-loop_NTPase <1088..1182 CDD:304359 32/85 (38%)
smc4NP_775360.2 ABC_SMC4_euk 81..>240 CDD:213241 48/163 (29%)
SMC_N 82..1273 CDD:280601 314/1317 (24%)
DUF4349 <274..435 CDD:305044 42/177 (24%)
SMC_hinge 612..726 CDD:214944 25/122 (20%)
MIT_CorA-like <866..1025 CDD:294313 30/167 (18%)
ABC_SMC4_euk <1180..1274 CDD:213241 32/85 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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