DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and smc-3

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001255118.1	Gene:	smc-3 / 176559	WormBaseID:	WBGene00004873	Length:	1205	Species:	Caenorhabditis elegans

Alignment Length:	1219	Identity:	496/1219 - (40%)
Similarity:	750/1219 - (61%)	Gaps:	35/1219 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |.||::.|.||:||||.|.|..|..|.|||||||||||||||:|||||||||:.||:.|||..||
Worm     1 MKIKEVRITGFRSYKDNTNVSGFSPRSNVVVGRNGSGKSNFFHAIQFVLSDEYAHLKEEQRLGLL 65

  Fly    66 HEGTGARVISAYVEIIFDNSDNR-VPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAG 129
            ||.||.:|..|.|||.||||:.| :..:..|:.:.|.:|.|||||:::.|:|||.|||||:||||
Worm    66 HESTGPKVAHARVEITFDNSEKRLMAFENSEVKIVRQVGKKKDQYYIDNKMVPRAEVVNLMESAG 130

  Fly   130 FSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLK 194
            ||.|||||||||||||::||:.|:|:|||||||||||||||||||||.:|:||..|.|||...||
Worm   131 FSRSNPYYIVKQGKINELATSPDAYKLKLLREVAGTRVYDERKEESLKILKETKMKTEKIQGLLK 195

  Fly   195 TIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDT---KKALDE--LQLQRKSSSDKKK 254
            .|::||||||.|||:||||||.|||:|::||..|:...|:.   |..|||  ::|.:|.::.|.:
Worm   196 YIDERLQTLENEKEDLKEYQKLDKTKRSVEYTMYDNTNKEAIKEKTKLDEQKVELNQKDNNVKSQ 260

  Fly   255 IYNIEIQKAQEKIKDVQKNLKEAKKKVQS----TKEERSVLMTEQQQLLREKTKLDLTIVDLNDE 315
            :.::..:.|:         ||..|||::|    .:|::..|..|:.:::.||..|.|.|..||:|
Worm   261 LNDVIAEMAK---------LKTDKKKLESLGRGLREDKETLQAEETKMVEEKMTLKLEIDSLNEE 316

  Fly   316 VQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQG 380
            ...:.:.::.|:..|:.:...|.:.|:|||.:||:|..:..:|.....::::.|.:.||:.||||
Worm   317 NTRERQGRQNAEHSLQGVGDEIFKNEEELDTIKPEYAKLLEEESRLKTDIRIDESRAKEILAKQG 381

  Fly   381 RGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLR 445
            :.|||||.:||||::.||::.||....|.......:.::|......::.|..:|:..|..:::.|
Worm   382 QRSQFSSVDDRDKFLRNEIRRISGLIADNKEREETIQKELADVEREDEKLNNEIQSISRTIDENR 446

  Fly   446 LQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCD 510
            .::|....|...||:..|.....:....|:|..:..::...::::|.|:..||.:..:|:.||..
Worm   447 YEMDTFAAKSTSLKQEYDAAYVAQQTAAREEKAIRDKIGNTEQDISAANDQLRRIVARPVYNGIT 511

  Fly   511 SVRKVLDSFV--ERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQI 573
            .||||::.|.  .|.||..::...|||.|||.........|||||.|.||||:|:||::...|:|
Worm   512 GVRKVIEEFKHDNRNGQHDDVINGYYGTVIELAEVPDMFRTAVEVIAQNRLFYHVVETDRIATKI 576

  Fly   574 LKEMNKLKLPGEVTFMPLNRLQV-KIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNL 637
            |::.|:::||||:.|.|:||:.. :..|..::.::.||...:.|:.|:||..:.|....:|.|.|
Worm   577 LRKFNEMQLPGEINFFPMNRVSAPRQRDLSNNSNARPMSDVIDYEVQYDKVFKSITANVIIVRTL 641

  Fly   638 ERATELAKSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRN 702
            ::|....::.|.|.|::||||:|.||.:|||:.:..||:||:..::..:|.::||.:|.|::...
Worm   642 DQAARDLRNEGFDVVSVDGDQMSKKGVMTGGFIDKKRSKLELHTQKDRFTKELAELQKSLAEAEK 706

  Fly   703 ELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEI----RLMKEELVRIEQYRAPKERSLAQC 763
            .::........|.:.||:.|.:.|.    |.:...|:    ..:.::...:...:.||:..|...
Worm   707 MVRERTQEAEKIRNRMQQHENQIGD----FHRKHRELTEAKNAISQQFYMVTSTKEPKKDQLLGI 767

  Fly   764 KASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKL 828
            |..|..:.:.|.:.|.|:...:.|.|:|.:::.:.:|...:..:.::......:||....|||.:
Worm   768 KNHLRELLAQKENFEQEIGSNMSSQLTSDEEQTVKKLRKKVDEMTKQLATVSRRRMDLMHRKNAI 832

  Fly   829 DNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQL 893
            :|||...|::.::.|...:.:||..:|:.||.|...:|.|...|::.....|......:.:....
Worm   833 ENLLTKKLYKTKESLTARVDDISDNERRHKLENANAQLTSLLTRMESTRKQLATAISELQDYETK 897

  Fly   894 QKELQQELETHVRKEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPL-VDPSYT 957
            :|.||..::..:.::::.|:.......|.:|.:.||:.:.:|.::..:|:..|||:|. ....:.
Worm   898 EKALQINIDNVLEQQRDLEKQQADFQLQYDKITAKEDEVKQKREDSLKKMRLLGALPTDTFSKWQ 962

  Fly   958 RMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEM 1022
            .:..:.:.|:|.:....||||.:||||||||:::.|.|||:|.:|..|....:..|..|::.||.
Worm   963 NVKPRELEKKLLECVNELKKYENVNKKALDQYMTASSQKEELTKRMAEQKKSEDSIEELLKVLEN 1027

  Fly  1023 QKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTG 1087
            :|.|||..||:||.:||.:|||:|||.|.|.:.::.::...|  |:.:.:.:.:.||.:.|||..
Worm  1028 RKYEAIDLTFKQVKKNFEQVFKQLVPHGRGKMQMRAREQRDD--EEGINSVELYEGISVLVSFVS 1090

  Fly  1088 --VEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDT 1150
              .::|.|||.|||||||||||||:|||||||||||||||||||.||||.|||:||:||..|||.
Worm  1091 DDGDSETREMTQLSGGQKSLVALAIIFSIQKCDPAPFYLFDEIDAALDAQHRKSVADMIQSLSDQ 1155

  Fly  1151 AQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVEDDSTH 1199
            |||:|||||||||..|.|||||||||||||||.||||:|.||||||:||
Worm  1156 AQFVTTTFRPELLATAEKFYGVRFRNKVSHIDSVTREQAYDFVEDDTTH 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	478/1197 (40%)
		ABC_SMC3_euk	3..>159	CDD:213239	100/156 (64%)
		SMC_hinge	533..643	CDD:214944	43/110 (39%)
		TMPIT	678..>760	CDD:285135	15/85 (18%)
		CHD5	<780..>822	CDD:282299	7/41 (17%)
		P-loop_NTPase	<1088..1182	CDD:304359	76/93 (82%)
smc-3	NP_001255118.1	Smc	1..1198	CDD:224117	489/1211 (40%)
		ABC_SMC3_euk	3..>151	CDD:213239	95/147 (65%)
		SMC_hinge	534..646	CDD:214944	43/111 (39%)
		P-loop_NTPase	<1093..1187	CDD:304359	76/93 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167167
Domainoid	1	1.000	839	1.000	Domainoid score	I23
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3974
Inparanoid	1	1.050	875	1.000	Inparanoid score	I205
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54174
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	1	1.000	-	-		FOG0003940
OrthoInspector	1	1.000	-	-		oto19556
orthoMCL	1	0.900	-	-		OOG6_101525
Panther	1	1.100	-	-	LDO	PTHR43977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910