DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and smc-4

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:NP_497935.1 Gene:smc-4 / 175603 WormBaseID:WBGene00004874 Length:1549 Species:Caenorhabditis elegans


Alignment Length:1402 Identity:288/1402 - (20%)
Similarity:547/1402 - (39%) Gaps:341/1402 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |:.:.:..||||..:..:.||.|....::|.|||||||...::.||.....:.:|..:..:|:|:
 Worm    92 IRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVSNLIHK 156

  Fly    68 GTGARVISAYVEIIFDN-----SDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLES 127
            ..|.......|.|.|..     ....|..|.|....|.........|.::.:...:|||...|..
 Worm   157 SAGRNPDKCTVTIHFQRIVDIPGHYEVVKDSEFTISRTAFQNNSSSYAIDGRPATKNEVEARLRR 221

  Fly   128 AGFSSSNPYYIVKQGKINQMA-------TAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSK 185
            ......:..:::.||::.|:|       |.:::..::.|.::.||    .|.|..:.|.:.   :
 Worm   222 VDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDIIGT----NRLEPFVKLFQR---R 279

  Fly   186 VEKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSS 250
            |.::     |.:...|.:..:.....:....:..|..:|::..|.|.......|:  |.:|:...
 Worm   280 VNRL-----TCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEATTIHMKLE--QRRRQRYL 337

  Fly   251 DKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDE 315
            ||......|:.|.:|::|.:.:.|...|.:.:.::|.:.|::.|:.:|.:....|...:.||..|
 Worm   338 DKIAPKQAELDKMKEEMKSIAETLDTNKNEYKQSEEAQKVMIEERSKLDKNFDSLSKELSDLGTE 402

  Fly   316 VQGDNKSKERADQELKNLKVTIAEREKEL---DDVKPKYEAMKRKEEDCSRELQL---------- 367
               :.:.||...:...|:....||:|||:   .:::...|..:||...|..|::.          
 Worm   403 ---ETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQEEVEQLLEIEKTANE 464

  Fly   368 ----------------KEQKRK--ELYAKQG------RGSQFSSREDRDKWITNELKSISKQTRD 408
                            ||:::|  |.:|::.      ||....:|||.:     :||.::....|
 Worm   465 EADKNLDEFEKRSEAPKEEQKKIQETWAQKSNEFNKVRGEARIAREDFE-----DLKKLANSGTD 524

  Fly   409 KIAHHAKLVEDLKKDATSEKD-----------LGQKIEEHSSELEQLRLQIDEHNKKYYELKKTK 462
            |:....|.:|..::....|||           ...|:::.|:||..||   :...:|..:|.||:
 Worm   525 KLIELKKRLESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTELPTLR---NTARQKNQDLAKTR 586

  Fly   463 DQHQSMR--NELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQ 525
            |:.:::|  |.......::.|.|...||            ||:            :.||..|.|.
 Worm   587 DRLETLRQQNSSCSSSNKVIQALMKEKE------------AGR------------IKSFHGRLGD 627

  Fly   526 SAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMP 590
            ...|...|.|.:..||..              ||.:.||..|.:...::..:...|||.: |..|
 Worm   628 LGVIDPKYEGAICTNFGA--------------RLNYLIVGKEEDAKNVINFLVANKLPRQ-TVQP 677

  Fly   591 LNRLQVKIHDYPDDP-------------DSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATE 642
            |::::....|...:|             |..|::....||.....    |.|.:  .:..:|...
 Worm   678 LDKIKCDKRDLAPNPTNPLPAPRLIDLIDCDPVLKPAFYDMVRSA----IVGDS--TQEAQRMHR 736

  Fly   643 LAKSTGLDCVTLDGDQVSSKGSLTG------GYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLR 701
            :....|:...||:|..:...||.||      |...|.::::..|....:..:: .:..:||.|||
 Worm   737 MPACRGVTVCTLEGSMIHPSGSFTGGGKTVKGLILTDKNKMAKQVTPEDKAAE-RDLAEKLGKLR 800

  Fly   702 ---NELKSTENNIN-SIVSEMQKTETKQGKSKDVFEKVQG---EIRLMKEELVRIEQYRAPKERS 759
               :|||..|:.:: .::...:|......:...|...||.   .|..:|:.:       |.:|:.
 Worm   801 DEADELKGQEHEMDGQLIEARRKVAEMSNRLSIVTSSVQSAAPAIETLKKTI-------ANQEKE 858

  Fly   760 LAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVR 824
            .|:.|...:::         |.||:::..|    :::.|:|.::..::.....|.          
 Worm   859 AAKVKVDAKTL---------EDKQKIVEEL----EKKRDELGEEAAKVKARQAEI---------- 900

  Fly   825 KNKLDNLLINNLFRRRDELIQALQE------------ISVEDRKRKLNNCKTELVSAEKRIKKVN 877
            ::|||.:....:...|||..::||:            .::.:..|.:..|...:...:|.|:|:.
 Worm   901 QSKLDGIFKELVQCHRDEAKESLQKRQKLEKDIAKETANISNSGRNIAKCDENISRHDKDIEKMK 965

  Fly   878 SDLEEIEKRVM--EAVQLQKELQQELETHVRK-EKEAEENLNKDSK----------QLEKWS--- 926
            ...||:.::.:  |.|:.:||..:..|..::| :.:.||...|.|:          :|:|.|   
 Worm   966 KKCEELMEKAIDDEEVKSKKETVERFEKQIKKLQTKGEEMTKKQSELSAAETKLEGELKKCSEGI 1030

  Fly   927 --TKENMLNE--KIDECTEKIASL-------------------------GAVPLVDPSYTRMSLK 962
              .||:||.:  |:::..:|:|:|                         ..:|:||.:.:.    
 Worm  1031 KELKESMLADRLKVEDIEKKLAALKVNRIPRFQFLIESSRPEDLEMQIDDKMPVVDENQSP---- 1091

  Fly   963 NIFKELEKANQHL------------------------------------------KKYNHVNKKA 985
               :|:|:..:|:                                          :|.|.::.:.
 Worm  1092 ---EEVERQKKHMACVMSDAAYALEFEMRQKVLENTESYENVDGEDRVPVELLSDEKINEISSRD 1153

  Fly   986 LDQF---LSFSEQKEKLYRRKEEL-----------DIGDQKIHMLI------------QSLEMQK 1024
            .::.   |...||:.:..:.|.::           ...:|.|.:.|            |.::..:
 Worm  1154 AEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQYNEQVIKLTIATEVHRKHNQELQRIKQMR 1218

  Fly  1025 VEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVE 1089
            :|.....|..:.::...|||.|.             :.||...:.::..|.|.. ||.......:
 Worm  1219 LEEFHSAFEFIGKHLVAVFKMLT-------------DGGDAKLEYIDKDDPFRQ-GISFMVRPAK 1269

  Fly  1090 AEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFI 1154
            ...:::..||||:|:|.:|||||::....|.|||:.||||.|||..:...:|..:.:.::.||||
 Worm  1270 KAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSIIAQYVRQKTENAQFI 1334

  Fly  1155 TTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKD 1191
            ..:.|..:.|.|::..|      :..:|..||..|.|
 Worm  1335 IISLRNNMFELANRLVG------IYKVDGCTRNVAID 1365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 283/1389 (20%)
ABC_SMC3_euk 3..>159 CDD:213239 39/167 (23%)
SMC_hinge 533..643 CDD:214944 24/122 (20%)
TMPIT 678..>760 CDD:285135 18/88 (20%)
CHD5 <780..>822 CDD:282299 7/41 (17%)
P-loop_NTPase <1088..1182 CDD:304359 31/93 (33%)
smc-4NP_497935.1 ABC_SMC4_euk 90..>252 CDD:213241 39/159 (25%)
SMC_N 91..1361 CDD:280601 285/1396 (20%)
SMC_hinge 618..734 CDD:284001 28/136 (21%)
MCP_signal 865..1037 CDD:304920 37/194 (19%)
ABC_SMC4_euk <1261..1362 CDD:213241 35/106 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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