Protein Alignment SMC3 and smc-6

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_496476.2
• Gene: smc-6 / 174776
• WormBaseID: WBGene00010056
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 1339
• Identity: 266/1339 - (19%)
• Similarity: 478/1339 - (35%)
• Gaps: 445/1339 - (33%)

  Fly    32 GRNGSGKSNFFYAIQFVL----SDEFTHLRPEQRQSLLHEGTGARVISAYVEIIFDNSD-NRVPI 91
            |.||||||..|.||...|    ||   :.|....:|.:.:||    ..:.:.|...|:. |..|.
 Worm    77 GPNGSGKSALFAAINLGLGGRGSD---NDRGNTVKSYIKDGT----TQSKITITLTNAGLNAHPD 134

  Fly    92 DKEEIFLRRVIGAKKDQYFLN-----------KKVVPRN--EVVNLLESAGFSSSNPYYIVKQG- 142
            ..:.|.:.|.|......|.:.           :::|.|.  :|..::.......|||.:.:.|.
 Worm   135 FDDLISIERTINQASSTYIMKSVKVTSSDNHVERIVSRKKADVDRIVSRFSIHLSNPAFWMSQDR 199

  Fly   143 --------------KINQMATAADSYRLKLLREV-------------AGTRVYDERKEESLNLLR 180
                          |:...:|..::.||..:|..             ||..:.:::|.:.:...|
 Worm   200 SRSFLANFKPANVYKLYLESTNLENIRLSYIRFADALDECFALIQLKAGEILNEQKKLKRMQEQR 264

  Fly   181 ETDSKVE----------------KISEYLKTIEDRLQTLEEEK----EELKEYQKWDKTRRT--- 222
            :..:|::                |:.:|...||..|:..|.:|    |..|||.| ::..||
 Worm   265 DLQAKLDQDRALVASFCWKLLFCKVRDYNDQIELTLKKQEAQKTLQDETKKEYAK-NRAARTEVE 328

  Fly   223 --LEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNL--KEAKKK--- 280
              ::..|.|.|::|.:.|.....|..|    |:|:...|     |||::.::::  |.::||
 Worm   329 KKIQEFRDEVEVQDAEIAEAREDLDAK----KRKVLEFE-----EKIRECEQSIRKKTSEKKYME 384

  Fly   281 --VQSTKEERSVLMTEQ--QQLLREKTKLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAERE 341
              :.:.|.|..:|:.:|  |.|.:..||::....|:         |::|.:.||......:.|:
 Worm   385 RTIVNAKNEVRILLEKQGNQDLTKRLTKVENDYKDI---------SQQRENMELGGESAKLREK- 439

  Fly   342 KELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQT 406
              ||.|...|   |||||              |.|..|           ||          ..|.
 Worm   440 --LDTVITDY---KRKEE--------------EKYTIQ-----------RD----------INQL 464

  Fly   407 RDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSM-RN 470
            |.||...   :|.:::...::||...|...|.:|:             ..|:.::|.:.|:: :.
 Worm   465 RRKIEQD---METMRRSRATKKDAINKFGSHMAEI-------------LMEINRSKSRFQTVPKG 513

  Fly   471 ELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYG 535
            .|.:..|.:..:.....||                   |  :..:.::|:......|||.|
 Worm   514 PLGKYITLIDPKWAFTVEE-------------------C--IGNLANNFLCSSHLDAEILR---- 553

  Fly   536 PVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVKIHD 600
                      .|:.::.:.|.:|           .|.|:.:.|             .|....:|:
 Worm   554 ----------NIFQSLRIPAQDR-----------PTIIVAKCN-------------GRAYTNLHE 584

  Fly   601 YPDDPDSIPMISKLKYDEQHDKALRYIFGKT-----LICRNLERATELAKS-----TGLDCVTLD 655
            ...|..||..:.|....:.|:    .|..|:     ::..:...|.||..|     ..:...|||
 Worm   585 PSSDFKSIYRVLKFSDPDVHN----VIIDKSNCEQFILIEDKTEAMELMGSNYPPQNAVKAYTLD 645

  Fly   656 GDQV------------SSKGSLTGGYFNTSRS-------------------RLEMQ--------- 680
            |.|.            |.:|....|.|...:.                   |||.|
 Worm   646 GSQAYANGPNSQYRFYSGRGGHARGTFGNDQGDVDEGALARLIEDTKSEAMRLETQDLRKQDHEL 710

  Fly   681 ----KKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRL 741
                .:|.:..:.|.||::|||.||::             |:|    |:.::||
 Worm   711 KVIYNERDQTKAAIDEFDRKLSNLRSQ-------------ELQ----KERQAKD----------- 747

  Fly   742 MKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRR 806
                 :|.|..:...|..:.....|:|.|......:|.|:|..|         :.:..:..|:..
 Worm   748 -----LRAELAQTANEDQVENLNESIEEMQKKIPLIEDEVKDIL---------KNVADITADMAP 798

  Fly   807 LNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEK 871
            :.||.|||  :....|::|...|       |..:.:.:|  .|:|..|...::...:.:.|.|::
 Worm   799 VIQERKEA--EHTLAEIQKETRD-------FASKSQKLQ--NELSKYDDAGEILKIRLDKVKADE 852

  Fly   872 RI-----KKVNSDLEEIEKRVMEAVQLQK----------------------ELQQELETHVRKEK 909
            .:     .|:.|:.::    .||.|:..|                      |.|:::|...:...
 Worm   853 GVFFHTEAKLKSERDD----AMEMVENDKKNHPMPPGETDPPDLSSFPSTTEAQRKIEEMQKAVD 913

  Fly   910 EAEENLN--------KDSK-QLEKWSTKENMLNEKIDECTE-KIASLGAVPLVDPSYTRMSLKNI 964
            .|....:        ||.| :|::......|:.:.:.|... ..|.:.|.|.: ..:|.:.:.|.
 Worm   914 RATVGCDTTITLECVKDFKDKLKRLKYLCRMIEDVLIELKNLHAARVKAYPSL-KKFTELKVCNK 977

  Fly   965 FKELEKANQHL---KKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVE 1026
            |:||.....|.   .:::| .|:.|:..:..|::|:.:..|:.|:             ||:::|:
 Worm   978 FQELLAVRGHFIGGLEFDH-EKETLNVNVQSSKEKDAMAGRRPEV-------------LEVEEVD 1028

  Fly  1027 AIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAE 1091
              :.::...:.:.|...:|             |..:..:.:|.|
 Worm  1029 --EHSYDDDSDDSTGPRRK-------------KSKKSGQKKKRV--------------------- 1057

  Fly  1092 MREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTA----Q 1152
             |::..||||::|.|..||:.|:.:....||.:.||.|..:|.|:||.|.:::.||:...    |
 Worm  1058 -RDLKGLSGGERSFVTAALVMSLWEVMEQPFRMMDEFDVFMDMMNRKLVMDLLVELATKKFPHNQ 1121

  Fly  1153 FITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKD 1191
            ||  .|.|:         |::..|.|..:........:|
 Worm  1122 FI--FFTPQ---------GIKELNMVDGLQVFEMNRVRD 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	265/1326 (20%)
smc-6	NP_496476.2	P-loop containing Nucleoside Triphosphate Hydrolases	47..>206	CDD:476819	32/135 (24%)
		SMC_prok_B	227..>869	CDD:274008	162/837 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1056..1148	CDD:476819	31/124 (25%)