Protein Alignment SMC3 and smc-5

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_494935.1
• Gene: smc-5 / 173874
• WormBaseID: WBGene00016151
• Length: 1076
• Species: Caenorhabditis elegans
• Alignment Length: 1299
• Identity: 262/1299 - (20%)
• Similarity: 498/1299 - (38%)
• Gaps: 355/1299 - (27%)

  Fly     5 QIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHL-RPEQRQSLLHEG 68
            :::...|.:|:..:.:.....  |:::|.||||||:....|..........| |.|:....:..|
 Worm    24 RVVFHNFLTYEHTSFLPTASL--NMILGHNGSGKSSIICGICLACGGSPKSLGRSERIVEYIRHG 86

  Fly    69 TGARVISAYVEIIFDNSDNRVPIDKEE----IFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAG 129
                ....||||..        .||::    :.|...:| ::.:|.||.....::|:.:|.:...
 Worm    87 ----CTEGYVEIAI--------ADKQKGPQVVRLTIRVG-EQPKYRLNDSATTQSEIADLRKHYN 138

  Fly   130 FSSSNPYYIVKQGKI--------------NQMATAA--DSYRLKLLREVAGTRVYDERKEESLNL 178
            ....||...:.|.|:              .:.|.:|  |...:.|:::...:...:::...|.|.
 Worm   139 IQIDNPCAFLAQDKVKSFSEQSSIELLRNTEKAASADLDQQHIDLMKQREDSTSIEDKCTTSENA 203

  Fly   179 LRETDSKVEKI----SEYLK--TIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETEL----- 232
            ::..:.::.||    ..|.|  .::.:|:.| |:|.::.|::|:|:        .|:.||
 Worm   204 IKRLEDEIGKIMPLVENYRKKLALQSKLRLL-EKKMKIMEFEKFDR--------EYKAELQNMDG 259

  Fly   233 -----KDTKKALDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLM 292
                 ::.:|::.|.:..||:..|:       |:|.:.:|..:|::..|...|||...:::  ||
 Worm   260 AMIEYREVEKSIAECEKHRKNLEDR-------IKKDRSQISQMQRSCNEILAKVQEKGDKK--LM 315

  Fly   293 TEQQQLLREKTKLDLTIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRK 357
            .:..|  |.|.||:              .:|:.|||.
 Worm   316 EDMMQ--RAKAKLE--------------SAKKAADQH---------------------------- 336

  Fly   358 EEDCSRELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKK 422
            |:|..:..::.:|.|..|   |......:..|:    ..:|:||:.                 :|
 Worm   337 EKDVEKARKMIDQARARL---QEAVDTLNGYEE----FQSEMKSLE-----------------QK 377

  Fly   423 DATSEKDLGQK---IEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKETQMTQQ-- 482
            .:|:|:|..|:   |::.|.|:.||      .|||       :|:.|:         :|:.:|
 Worm   378 YSTAERDSRQEEDAIQKKSYEMRQL------ENKK-------RDEEQN---------SQLNRQDR 420

  Fly   483 ---LQTHKEELSRA----DQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARAYYGPVIEN 540
               ||....:.|:|    .|......|...:...|.|.|           :.|.|:|     :||
 Worm   421 YRVLQNFSSDASKAYRWYQQNRSQFKGDVYMPIMDMVLK-----------TPEAAKA-----LEN 469

  Fly   541 ---------FSC----DKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLN 592
                     |.|    |:.:....:  .:.|:...:|.:|    :|..|....:||.|::.:...
 Worm   470 SVGVRDRTMFVCCYKEDELLINGKQ--HSWRINTSVVPAE----KIYSEDIDAQLPSELSRLGFK 528

  Fly   593 RLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLDCVTLDGD 657
            .|.....|.|     .|:                   |..:|          ..:||:.:...|.
 Worm   529 YLVSNCFDAP-----APL-------------------KQFLC----------NVSGLNRIPFGGS 559

  Fly   658 QVSSKGSLTGGYFNTSR------SRLEMQKKRTEY----------TSQIAEFEKKLSKLRNELKS 706
            .|..|.:........:|      :.:..|..::.|          |.:...:..:..|:....|.
 Worm   560 DVEKKIAEVSQAIEQTRYSVFLTANIRCQNSKSRYANNTLQSQSATREANTWRDQFFKVSPVAKR 624

  Fly   707 TENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMT 771
            |:   |||:.|:|              |::.||.:..|:| |.::....|||.:.:.:   :...
 Worm   625 TD---NSILEEIQ--------------KLKAEIDIRSEQL-REKRGAIQKERDVLRQE---QMQW 668

  Fly   772 STKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQE--NKEAFTQRMQFEVRKNKLDNLLIN 834
            .:|..:..:.|.||.|.::..:..|.:.:  ||..:.:|  |.|   ::...|.:|      ::.
 Worm   669 KSKKQVHTKWKTELASEMAKLEALENEVV--DISAIEEEYANVE---KKAILETKK------MLE 722

  Fly   835 NLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQ 899
            |..|...|:|...:.|.:.:....:  ||:       |:.|.||:.|....::.:...::...:.
 Worm   723 NSIRWHKEIIDKHRLIGIFELSESI--CKS-------RVNKSNSEAETHRSKLEDLKSVKDAAED 778

  Fly   900 ELETHVRKEKEAEENLNKDS--KQLE--KWSTKENMLNEKIDECTEKIASLGAVPLVDPSYTRMS 960
            .|:|.:..:|.|...|.|:.  |.|:  |.|..||.:...:.:..|:......:..:|.:.|  |
 Worm   779 LLKTALNHKKAAASALMKECSLKTLDESKMSPAENKIYSSLVKMFEEADVPTDMNTLDQAIT--S 841

  Fly   961 LKNIFKELEKANQHLKKYNHVNKKALDQFLSFSE-QKEKLYRRKEEL--DIGDQKIHMLIQSLEM 1022
            .|...|..|.:.:.....:....|.||..|...: ::|||...:..:  .:||:     |.:...
 Worm   842 EKTRLKLAEDSGEDGSIVHEQRLKVLDDDLVLEKTRQEKLIENRARIHDKLGDE-----INNWRK 901

  Fly  1023 QKVEAIQFTFRQVAQNFTKVFKKLVPMGA-GFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFT 1086
            :    ::....|:..|:.:.|..|   |. |.:.|:..:|..| :||        .||.|.|.|.
 Worm   902 E----VETMIEQINVNYVQFFDSL---GCRGEVSLEVPENPLD-IEK--------YGIMIMVCFR 950

  Fly  1087 GVEAEMREMNQL-SGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMI------ 1144
            ..|:..|..|:: |||::|:..:..:.::|:..|.||...|||:|.:|..:.:.|.:::
 Worm   951 KGESMKRLDNKVQSGGERSVATMLYLLALQQLCPVPFRCIDEINQGMDPTNERKVFDIMVGMWNG 1015

  Fly  1145 --HELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHI---DCVTREEAKDF---VEDDSTHA 1200
              ..||.|..|:.:   |:||      :|:..|..|:.:   ..:|....|.:   .:.|:|.|
 Worm  1016 TTGTLSKTQYFLLS---PKLL------HGLDMRENVNIVMVNSTLTNSHGKHYDTSAKIDATFA 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	257/1271 (20%)
smc-5	NP_494935.1	P-loop containing Nucleoside Triphosphate Hydrolases	20..>180	CDD:476819	35/170 (21%)
		SMC_prok_B	165..1001	CDD:274008	214/1063 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<947..1052	CDD:476819	29/113 (26%)