Protein Alignment SMC3 and Smc2

DIOPT Version :9

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001288341.1
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1346
• Identity: 324/1346 - (24%)
• Similarity: 587/1346 - (43%)
• Gaps: 327/1346 - (24%)

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            |::|.||::|||||..:|.|..||...|.:.|.|||||||...:|.|:|. ...:.:|....|.|
Mouse     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNR-VPIDKE---EIFLRR--VIGAKKDQYFLNKKVVPRNEVVN 123
            :::...|.:..|.|.|.|||||.: .|:..|   ||.:.|  |||. :::|.:|........|.:
Mouse    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGG-RNKYLINGVNANNTRVQD 129

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            |..|.|.:.:||::::.||:|.::........|.::.|.||||:|:.:|..:...:.:.::|:::
Mouse   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKE 194

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLE-----YIRYE-TELKDTKKALDELQLQRK 247
            |...|:  |:...|:::.|||...|.::.|..|.:|     ||.|: ...:|||:         :
Mouse   195 IKTILE--EEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLRAEDTKE---------R 248

  Fly   248 SSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDL 312
            |:.        |:::.|:||.::|:.|.|.:||:::       |..|.::|.|.|.|
Mouse   249 SAG--------ELKEMQDKIVNLQEVLSENEKKIKA-------LNCEIEELERRKDK-------- 290

  Fly   313 NDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYA 377
              |..|..||.|.|..|.:.:..    :.:...|:|.|             .|..:|.|||||..
Mouse   291 --ETGGKLKSLEDACAEAQRVNT----KSQSAFDLKKK-------------NLASEETKRKELQN 336

  Fly   378 KQGRGSQ-FSSREDRDKWITNELKSI---SKQTRDKIA---HHAKLV------------------ 417
            .....|: .:::|...|.||:.|..:   |.:..:.:|   .|...|
Mouse   337 SMAEDSKALAAKEKEVKKITDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQ 401

  Fly   418 -----EDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKET 477
                 .|:.|..|..|....|::....||:..:.::.:.:..|   ||.:|..::::....:.||
Mouse   402 MIACKNDISKAQTEAKQAQMKLKHAQQELKSKQAEVKKMDSGY---KKDQDAFEAVKKAKEKLET 463

  Fly   478 QMTQ-QLQTHKEE--LSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIAR------AY 533
            :|.: ..:.:|||  |.:..|..|.      :|..            :|...|.:|:      ||
Mouse   464 EMKKLNYEENKEEKLLEKHRQLSRD------INNL------------KGKHEALLAKFPNLQFAY 510

  Fly   534 YGPVIENFS--------------CDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPG 584
            ..|. :|::              .|.:..||:||.|..||::.:|::|....::|:   |.:|..
Mouse   511 KDPE-KNWNRNSVKGLVASLINVKDNSTATALEVVAGERLYNVVVDTEVTAKKLLE---KGELKR 571

  Fly   585 EVTFMPLNRLQ--------VKIHDYPDDPDSIPM-ISKLKYDEQHDKALRYIFGKTLICRNLERA 640
            ..|.:|||::.        :::......||::.: :|.:.|..:..|.:.::||.|.:|.|::.|
Mouse   572 RYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVDYKPELQKGMEFVFGTTFVCNNMDNA 636

  Fly   641 TELA--KSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNE 703
            .::|  |......|||.||.....|:|:||             .|::..|.:.:|: ::..:::|
Mouse   637 KKVAFDKRIMTRTVTLGGDVFDPHGTLSGG-------------ARSQAASILTKFQ-EVKDVQDE 687

  Fly   704 LKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRI----EQYRAPKERSLAQCK 764
            |::.||                            |:|.::|||..:    |:||        |.|
Mouse   688 LRTKEN----------------------------ELRALEEELAGLKNVAEKYR--------QLK 716

  Fly   765 ASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAF--TQRMQ------F 821
            ...|..|.....|:.:|:|   |:...| |.|:|.|...|    :|::|..  |:.:|      :
Mouse   717 QQWEMKTEEGDLLQTKLQQ---SSYHKQ-QEELDALKKTI----EESEETLKSTKEIQKKAEEKY 773

  Fly   822 EVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKK-------VNSD 879
            |..:||:.|             .:|.:|..::|.::||:..||:..::.|::|:       :..:
Mouse   774 EALENKMKN-------------AEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLE 825

  Fly   880 LEEIEKR----------VMEAVQLQKELQQELETHVRKEKE-----------------AEENLNK 917
            |||:::.          |.||::..:...:::...|.|.||                 |::|:.|
Mouse   826 LEELKREHASNEQQLDAVNEAIKAYEGQIEKMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIK 890

  Fly   918 DS-KQLEKWSTKENMLNEKI--------------DECTEKIASLGAVPLVDPSYTRMSLKNIF-- 965
            |. .::.|.:.:.|....||              |:...|::.:    |.|..:.... |::|
Mouse   891 DKCAEVAKHNLQNNESQLKIKELDHSISKHKREADDAAAKVSKM----LSDYDWINAE-KHLFGQ 950

  Fly   966 ---------KELEKANQHLKKY--------NHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKI 1013
                     ...::|.|.|:|.        .:||.:|::......|:...|.::|..::....||
Mouse   951 PNSAYDFKTNNPKEAGQRLQKLQEVKEKLGRNVNLRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015

  Fly  1014 HMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTG 1078
            ...|:.|:.:|.:|:...:::|.::|..:|..|:| ||..::...            |......|
Mouse  1016 LATIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLP-GANAMLAPP------------EGQTVLDG 1067

  Fly  1079 IGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANM 1143
            :..:|:......|  .:.:|||||:|||||:||.|:....|||.|:.||:|.|||..|.:.:..|
Mouse  1068 LEFKVALGNTWKE--NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQM 1130

  Fly  1144 IHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEA 1189
            :......:|||..:.:..:..||:..:..:|.:.||.:...|:.:|
Mouse  1131 LRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQSQA 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	320/1334 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	56/162 (35%)
		SMC_hinge	533..643	CDD:214944	31/132 (23%)
		TMPIT	678..>760	CDD:285135	15/85 (18%)
		CHD5	<780..>822	CDD:282299	13/49 (27%)
		P-loop_NTPase	<1088..1182	CDD:304359	34/93 (37%)
Smc2	NP_001288341.1	Smc	1..1168	CDD:224117	322/1336 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810